Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease

Autor: Christopher J. Minnis, StJohn Townsend, Julia Petschnigg, Elisa Tinelli, Jürg Bähler, Claire Russell, Sara E. Mole

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Abstract Juvenile CLN3 disease is a recessively inherited paediatric neurodegenerative disorder, with most patients homozygous for a 1-kb intragenic deletion in CLN3. The btn1 gene is the Schizosaccharomyces pombe orthologue of CLN3. Here, we have ex

Externí odkaz: https://doaj.org/article/6527e4bac2b54420a484033fbe621105

Towards a data-integrated cell

Autor: Noël Malod-Dognin, Julia Petschnigg, Sam F. L. Windels, Janez Povh, Harry Hemingway, Robin Ketteler, Nataša Pržulj

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Integration of omics data remains a challenge. Here, the authors introduce iCell, a framework to integrate tissue-specific protein–protein interaction, co-expression and genetic interaction data, enabling identification of the most rewired genes in

Externí odkaz: https://doaj.org/article/f16ba5ea82984765ad79c0f292ce025e

Author Correction: Towards a data-integrated cell

Autor: Noël Malod-Dognin, Julia Petschnigg, Sam F. L. Windels, Janez Povh, Harry Hemingway, Robin Ketteler, Nataša Pržulj

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-1 (2019)

The original version of this Article contained an error in the spelling of the author Harry Hemingway, which was incorrectly given as Harry Hemmingway. This has been corrected in both the PDF and HTML versions of the Article.

Externí odkaz: https://doaj.org/article/1d11223e7e4d4cb9a840512fa18fee90

Global network analysis in Schizosaccharomyces pombe reveals three distinct consequences of the common 1-kb deletion causing juvenile CLN3 disease

Autor: Claire Russell, Jürg Bähler, Elisa Tinelli, StJohn Townsend, Sara E. Mole, Julia Petschnigg, Christopher J. Minnis

Publikováno v: Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)

Juvenile CLN3 disease is a recessively inherited paediatric neurodegenerative disorder, with most patients homozygous for a 1-kb intragenic deletion in CLN3. The btn1 gene is the Schizosaccharomyces pombe orthologue of CLN3. Here, we have extended th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e45eede73a5b8251c520b4ea02ed2d
http://europepmc.org/articles/PMC7973434

Towards a data-integrated cell

Autor: Robin Ketteler, Julia Petschnigg, Nataša Pržulj, Noël Malod-Dognin, Harry Hemingway, Sam F L Windels, Janez Povh

Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)

We are increasingly accumulating molecular data about a cell. The challenge is how to integrate them within a unified conceptual and computational framework enabling new discoveries. Hence, we propose a novel, data-driven concept of an integrated cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fffe8e93f34b2ee8eb03782dcef739
https://hdl.handle.net/2117/187766