Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Julia Ohrndorf"'
Publikováno v:
ChemMedChem. 17
Publikováno v:
ChemMedChem. 17(8)
Several lines of evidence suggest the ligand-sensing transcription factor Nurr1 as a promising target to treat neurodegenerative diseases. Nurr1 modulators to validate and exploit this therapeutic potential are rare, however. To identify novel Nurr1
Autor:
Julius Pollinger, Julia Ohrndorf, Leonie Gellrich, Astrid Kaiser, Pascal Heitel, Stefan Knapp, Simone Schierle, Daniel Merk, Apirat Chaikuad
Publikováno v:
ACS Med Chem Lett
[Image: see text] The nuclear retinoid X receptors (RXRs) are key ligand sensing transcription factors that serve as universal nuclear receptor heterodimer partners and are thus involved in numerous physiological processes. Therapeutic targeting of R
Autor:
Daniel Merk, Sebastian Neumann, Simone Schierle, Astrid Kaiser, Julius Pollinger, Julia Ohrndorf
Publikováno v:
ChemMedChem. 14:1343-1348
Automated computational analogue design and scoring can speed up hit-to-lead optimization and appears particularly promising in selective optimization of side-activities (SOSA) where possible analogue diversity is confined. Probing this concept, we e
Publikováno v:
Journal of medicinal chemistry. 64(5)
The ligand-activated transcription factor nuclear receptor related-1 (Nurr1) exhibits great potential for neurodegenerative disease treatment, but potent Nurr1 modulators to further probe and validate the nuclear receptor as a therapeutic target are
Autor:
Julia Ohrndorf, Jurema Schmidt, Leonie Gellrich, Ewgenij Proschak, Daniel Merk, Simone Schierle, Jan Heering, Lena Kalinowsky, Whitney Kilu, Julius Pollinger, Astrid Kaiser
Publikováno v:
Journal of medicinal chemistry. 62(4)
The fatty acid sensing nuclear receptor families retinoid X receptors (RXRs) and peroxisome proliferator-activated receptors (PPARs) hold therapeutic potential in neurodegeneration. Valuable pleiotropic activities of Wy14,643 in models of such condit
Autor:
Julia Ohrndorf, Jan Heering, Daniel Merk, Ewgenij Proschak, Lena Kalinowsky, Pascal Heitel, Astrid Kaiser, Leonie Gellrich
[Image: see text] As universal heterodimer partners of many nuclear receptors, the retinoid X receptors (RXRs) constitute key transcription factors. They regulate cell proliferation, differentiation, inflammation, and metabolic homeostasis and have r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae44a54f7576c70083901774c214e10a
https://publica.fraunhofer.de/handle/publica/257970
https://publica.fraunhofer.de/handle/publica/257970