Výsledky vyhledávání - "Julia Ngyuen"

H-Ferritin Ferroxidase Activity Induces Cytoprotective Pathways and Inhibits Microvascular Stasis in Transgenic Sickle Mice

Autor: Chunsheng Chen, John D. Belcher, Gregory M. Vercellotti, Heather Bechtel, Robert P. Hebbel, Julia Ngyuen, Carol M. Bruzzone, Clifford J. Steer

Publikováno v: Blood. 120:378-378

Abstract 378 Hemolysis, oxidative stress, inflammation, vaso-occlusion and organ infarction are hallmarks of sickle cell disease (SCD). We hypothesize that intravascular heme, liberated from hemoglobin S derived from hemolyzed sickle red blood cells,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::783cb1e17b50f8de7b93d1fbbae36299
https://doi.org/10.1182/blood.v120.21.378.378

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Heme Oxygenase-1 Gene Therapy in a Murine Model of Sickle Cell Disease

Autor: Joan D. Beckman, Chunsheng Chen, Clifford J. Steer, Belcher D. Belcher, Carol M. Bruzzone, Julie V. Vineyard, Gregory M. Vercellotti, Julia Ngyuen

Publikováno v: Blood. 114:1527-1527

Abstract 1527 Poster Board I-550 We previously demonstrated that increases in heme oxygenase-1 (HO-1) and its products, carbon monoxide and biliverdin, inhibit inflammation and vasoocclusion in mouse models of sickle cell disease (SCD). In this study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd8659b537535d78f0a37da7c4e86e43
https://doi.org/10.1182/blood.v114.22.1527.1527

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Carbon Monoxide Decreases Leukocytosis in Murine Sickle Cell Disease Models Via Decreased Granulopoiesis

Autor: Joan D. Beckman, Chunsheng Chen, Julie V. Vineyard, John D. Belcher, Michael O Nwaneri, Paul C. Marker, Gregory M. Vercellotti, Julia Ngyuen

Publikováno v: Blood. 112:1433-1433

Elevated white blood cell counts (WBC) in sickle cell disease (SCD) are risk factors for morbid vaso-occlusive events including acute chest syndrome and stroke. The mechanisms of leukocytosis in SCD include increased inflammation, oxidative stress, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d83f3a774e46391e8ee31db4e27db3a
https://doi.org/10.1182/blood.v112.11.1433.1433

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