Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis

Autor: Lisa Spiecker, Daniel Sasca, Andrea Schüler, Piyush More, Ines Witte, Victoria Petermann, Markus Meyerhöfer, Julia Mehlig, Viral N. Shah, Nina Cabezas-Wallscheid, Thomas Kindler, Andreas Daiber, Sven Horke, Andrea Pautz, Hartmut Kleinert, Patricia S. Haehnel

Publikováno v: Oxidative medicine and cellular longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity

Background. Long-term hematopoietic stem cells (LT-HSCs) reside in bone marrow niches with tightly controlled reactive oxygen species (ROS) levels. ROS increase results into LT-HSC differentiation and stem cell exhaustion. Paraoxonase 2 (PON2) has be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe25f2205b615c3bfa97ab916451dd6
https://doi.org/10.1155/2021/3917028