Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Julia Mantaj"'
Autor:
Yunyue Zhang, Mona Belaid, Xiang Luo, Armond Daci, Rinë Limani, Julia Mantaj, Matthias Zilbauer, Komal Nayak, Driton Vllasaliu
Publikováno v:
Journal of Nanobiotechnology, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Oral delivery remains unattainable for nucleic acid therapies. Many nanoparticle-based drug delivery systems have been investigated for this, but most suffer from poor gut stability, poor mucus diffusion and/or inefficient epithel
Externí odkaz:
https://doaj.org/article/ed155bd831e14b01891e6d065e6e7236
Publikováno v:
Pharmaceutics, Vol 12, Iss 3, p 226 (2020)
Ingestion is the preferred way for drug administration. However, many drugs have poor oral bioavailability, warranting the use of injections. Extracellular vesicles (EVs) from cow milk have shown potential utility in improving oral drug bioavailabili
Externí odkaz:
https://doaj.org/article/5d2afabe43824d8ea76c95528f11c808
Publikováno v:
Pharmaceutics, Vol 11, Iss 7, p 298 (2019)
The aim of this study was to probe whether the transferrin (Tf) transport pathway can be exploited for intestinal delivery of nanoparticles. Tf was adsorbed on 100 nm model polystyrene nanoparticles (NP), followed by size characterisation of these sy
Externí odkaz:
https://doaj.org/article/692c212831d74f359cba90d6647e4798
Publikováno v:
Pharmaceutics, Vol 11, Iss 3, p 127 (2019)
Biologics have changed the management of Inflammatory Bowel Disease (IBD), but there are concerns regarding unexpected systemic toxicity and loss of therapeutic response following administration by injection. Local delivery of biologics directly to t
Externí odkaz:
https://doaj.org/article/c7f635c5e8b44119bfcdd838404bcc04
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0152303 (2016)
Pyrrolobenzodiazepines (PBDs) are covalent-binding DNA-interactive agents with growing importance as payloads in Antibody Drug Conjugates (ADCs). Until now, PBDs were thought to covalently bond to C2-NH2 groups of guanines in the DNA-minor groove acr
Externí odkaz:
https://doaj.org/article/f481e1a52951402a9e16790f61aff018
Publikováno v:
Pharmaceutics, Vol 10, Iss 4, p 188 (2018)
Biologics have changed the management of inflammatory bowel disease (IBD), but there are concerns with unexpected systemic toxicity and loss of therapeutic response following administration by injection. Rectal administration of biologics offers pote
Externí odkaz:
https://doaj.org/article/b8c8a6de404a4c72b4c416e50ab58873
Publikováno v:
Muraleetharan, V, Mantaj, J, Swedrowska, M & Vllasaliu, D 2019, ' Nanoparticle modification in biological media : implications for oral nanomedicines ', RSC Advances, vol. 9, no. 69, pp. 40487-40497 . https://doi.org/10.1039/C9RA08403G
Nanomedicine has shown potential in enabling oral administration of poorly absorbable drugs, such as biologics. As part of the process related to optimisation of the safety and efficacy of nanomedicines, it is imperative that the interaction of nanop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4762d7458c407f9b188cc21753993f8e
https://doi.org/10.1039/c9ra08403g
https://doi.org/10.1039/c9ra08403g
Publikováno v:
Pharmaceutics
Volume 11
Issue 7
Pharmaceutics, Vol 11, Iss 7, p 298 (2019)
Volume 11
Issue 7
Pharmaceutics, Vol 11, Iss 7, p 298 (2019)
The aim of this study was to probe whether the transferrin (Tf) transport pathway can be exploited for intestinal delivery of nanoparticles. Tf was adsorbed on 100 nm model polystyrene nanoparticles (NP), followed by size characterisation of these sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04eaafac3e0aaafd1edebe1b98dacef7
https://pubmed.ncbi.nlm.nih.gov/31248025
https://pubmed.ncbi.nlm.nih.gov/31248025
Publikováno v:
Angewandte Chemie. 129:474-502
Die Pyrrolo[2,1-c][1,4]benzodiazepine (PBDs) sind eine Familie sequenzselektiver Wirkstoffe, die an die kleine Furche der DNA binden und eine kovalente Aminalbindung zwischen der C11-Position und den C2-NH2-Gruppen der Guaninbasen bilden. Anthramycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece6232db2fa034df1062fcc7b46b683
https://doi.org/10.1002/ange.201510610
https://doi.org/10.1002/ange.201510610
Publikováno v:
Angewandte Chemie (International Ed. in English)
Mantaj, D J, Jackson, D P J M, Rahman, D K M & Thurston, P D E 2016, ' From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-drug Conjugates (ADCs) ', ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 55, pp. 2-29 . https://doi.org/10.1002/anie.201510610
Mantaj, D J, Jackson, D P J M, Rahman, D K M & Thurston, P D E 2016, ' From Anthramycin to Pyrrolobenzodiazepine (PBD)-Containing Antibody-drug Conjugates (ADCs) ', ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, vol. 55, pp. 2-29 . https://doi.org/10.1002/anie.201510610
The pyrrolo[2,1‐c][1,4]benzodiazepines (PBDs) are a family of sequence‐selective DNA minor‐groove binding agents that form a covalent aminal bond between their C11‐position and the C2‐NH2 groups of guanine bases. The first example of a PBD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::987b0669d8e4de64227efefa98dd303e
https://doi.org/10.1002/anie.201510610
https://doi.org/10.1002/anie.201510610