Výsledky vyhledávání - "Julia Maeve Bonner"

Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes

Autor: Yuan-Ta Lin, Alexander Frank, Li-Huei Tsai, Joel W. Blanchard, Michael Bula, Matheus B. Victor, Hansruedi Mathys, Jose Davila-Velderrain, Lena Zhu, Manolis Kellis, Julia Maeve Bonner, Tak Ko, Leyla Anne Akay, Hugh P. Cam, David A. Bennett

Publikováno v: Nat Med

In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition known as cerebral amyloid angiopathy (CAA), which impairs blood-brain barrier (BBB) function and accelerates cognitive degeneration. Apolipoprotein (APOE4) is th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796c6e72f10ca2eb5e7400e54801203f
https://doi.org/10.1038/s41591-020-0886-4

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APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

Autor: Leyla Anne Akay, Susan Lindquist, Agnese Graziosi, Sebastian Boland, William T. Ralvenius, Valeriya Baru, Aleksandra Alicja Arczewska, Nora Kory, Julia Maeve Bonner, Elana Lockshin, Grzegorz Sienski, Caroline A. Lewis, Priyanka Narayan, Blerta Milo, Manolis Kellis, Liang He, David M. Sabatini, Li-Huei Tsai

Publikováno v: Sci Transl Med
PMC

Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works The E4 allele of the apolipoprotein E gene (APOE) has been established as a geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4318185a6e20804c536d843839fba1
http://hdl.handle.net/11585/854127

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PICALM Rescues Endocytic Defects Caused by the Alzheimer’s Disease Risk Factor APOE4

Autor: Julia Maeve Bonner, Susan Lindquist, Leyla Anne Akay, M. Inmaculada Barrasa, Julie S. Valastyan, Agnese Graziosi, Valeriya Baru, Aftabul Haque, Yelena Freyzon, Grzegorz Sienski, William R. Hesse, Li-Huei Tsai, Priyanka Narayan, Yuan-Ta Lin, Jinsoo Seo, Blerta Milo, Dirk Landgraf

Publikováno v: Cell Reports, Vol 33, Iss 1, Pp 108224-(2020)
Cell Rep
Elsevier

Summary: The ε4 allele of apolipoprotein E (APOE4) is a genetic risk factor for many diseases, including late-onset Alzheimer’s disease (AD). We investigate the cellular consequences of APOE4 in human iPSC-derived astrocytes, observing an endocyti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33720e98ac0cff7e832c8e35452f808f
http://www.sciencedirect.com/science/article/pii/S2211124720312134

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Diverse structures, functions and uses of FK506 binding proteins

Autor: Julia Maeve Bonner, Gabrielle L. Boulianne

Publikováno v: Cellular Signalling. 38:97-105

FK506 (Tacrolimus), isolated from Streptomyces tsukubaenis is a powerful immunosuppressant shown to inhibit T cell activation. FK506 mediated immunosuppression requires the formation of a complex between FK506, a FK506 binding protein (FKBP) and calc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a70d3e450e27514a40a10efd18f8ac2
https://doi.org/10.1016/j.cellsig.2017.06.013

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Combined Isothermal Titration and Differential Scanning Calorimetry Define Three-State Thermodynamics of fALS-Associated Mutant Apo SOD1 Dimers and an Increased Population of Folded Monomer

Autor: Kenrick A. Vassall, Ming Sze Tong, Helen R. Broom, Colleen M. Doyle, Elizabeth M. Meiering, Jessica A.O. Rumfeldt, Julia Maeve Bonner

Publikováno v: Biochemistry. 55(3)

Many proteins are naturally homooligomers, homodimers most frequently. The overall stability of oligomeric proteins may be described in terms of the stability of the constituent monomers and the stability of their association; together, these stabili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1988bc0aaca7f415ba05b48a1e929c4
https://pubmed.ncbi.nlm.nih.gov/26710831

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Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity

Autor: Priyanka Narayan, Chad L. Myers, Can Kayatekin, Susan Lindquist, Jason Flannick, Saranna Fanning, M. Inmaculada Barrasa, Audra L. Amasino, Giorgio Gaglia, Jose C. Florez, Dirk Landgraf, Julia Maeve Bonner, Charles Boone, Michael Costanzo, William R. Hesse, Justin Nelson, David Pincus

Publikováno v: Cell. 173:62-73.e9

Aggregates of human islet amyloid polypeptide (IAPP) in the pancreas of patients with type-2 diabetes (T2D) are thought to contribute to β-cell dysfunction and death. To understand how IAPP harms cells and how this might be overcome, we created a ye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc051b4925fb8f2b30d93b9df1b00577
https://doi.org/10.1016/j.cell.2018.02.026

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Non-linear Effects of Temperature and Urea on the Thermodynamics and Kinetics of Folding and Unfolding of Hisactophilin

Autor: Elizabeth M. Meiering, Peter B. Stathopulos, Marc Sawyer, Hannah J. Wong, Julia Maeve Bonner

Publikováno v: Journal of Molecular Biology. 344:1089-1107

Extensive measurements and analysis of thermodynamic stability and kinetics of urea-induced unfolding and folding of hisactophilin are reported for 5-50 degrees C, at pH 6.7. Under these conditions hisactophilin has moderate thermodynamic stability,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::717373b7e2c0cab215ae1822e24d38e8
https://doi.org/10.1016/j.jmb.2004.09.091

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FKBP14 is an essential gene that regulates Presenilin protein levels and Notch signaling in Drosophila

Autor: Gabrielle L. Boulianne, Julia Maeve Bonner, Diana L. van de Hoef

Publikováno v: Development (Cambridge, England). 140(4)

Presenilins were identified as causative factors in familial Alzheimer's disease and also play an essential role in Notch signaling during development. We previously identified FKBP14, a member of the family of FK506-binding proteins (FKBPs), as a mo

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https://pubmed.ncbi.nlm.nih.gov/23318643

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Functional analysis of the NHR2 domain indicates that oligomerization of Neuralized regulates ubiquitination and endocytosis of Delta during Notch signaling

Autor: Julia Maeve Bonner, Sili Liu, Soline Chanet, Cosimo Commisso, François Schweisguth, Lara C. Skwarek, Gabrielle L. Boulianne

Publikováno v: Molecular and cellular biology. 32(24)

The Notch pathway plays an integral role in development by regulating cell fate in a wide variety of multicellular organisms. A critical step in the activation of Notch signaling is the endocytosis of the Notch ligands Delta and Serrate. Ligand endoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128eed4e7d28132756b6b838c8892a47
https://pubmed.ncbi.nlm.nih.gov/23045391

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