Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Julia M. Würz"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The structures and dynamics of large proteins can be studied with methyl-based NMR but peak assignment is still challenging. Here the authors present MethylFLYA that allows automated assignment of methyl groups and apply it to five proteins with mole
Externí odkaz:
https://doaj.org/article/a1784461fd9c43e19b12737b3b10db75
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications, 10 (1)
Nature Communications
Nature Communications, 10 (1)
Isotopically labeled methyl groups provide NMR probes in large, otherwise deuterated proteins. However, the resonance assignment constitutes a bottleneck for broader applicability of methyl-based NMR. Here, we present the automated MethylFLYA method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b153e8ae4395e41f74bcebb35de7a552
http://link.springer.com/article/10.1038/s41467-019-12837-8
http://link.springer.com/article/10.1038/s41467-019-12837-8
Autor:
Gerhard Hummer, Frank Bernhard, Robert Tampé, Rupert Abele, Lars V. Schäfer, Volker Dötsch, Julia M. Würz, Benesh Joseph, Franz Tumulka, Katrin Reichel, Frank Löhr, Christoph Bock
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
The ATP-binding cassette transporter TAPL translocates polypeptides from the cytosol into the lysosomal lumen. TAPL can be divided into two functional units: coreTAPL, active in ATP-dependent peptide translocation, and the N-terminal membrane spannin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8c1f3419960c9e2d760ea8a033293f
https://doaj.org/article/848161c3458d4b778156d6e149516c9c
https://doaj.org/article/848161c3458d4b778156d6e149516c9c
Autor:
Peter Güntert, Julia M. Würz
Publikováno v:
Journal of Biomolecular NMR. 67:63-76
The automated identification of signals in multidimensional NMR spectra is a challenging task, complicated by signal overlap, noise, and spectral artifacts, for which no universally accepted method is available. Here, we present a new peak picking al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4330a82ea6cc25a26c25bd4391f9cd4b
https://doi.org/10.1007/s10858-016-0084-3
https://doi.org/10.1007/s10858-016-0084-3
Methyl groups provide crucial NMR probes for investigating protein structure, dynamics and mechanisms in systems that are too large for NMR with uniform isotope labeling. This requires the assignment of methyl signals in the NMR spectra to specific m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a4dc773b7932feeb2812f906f7795f
https://doi.org/10.1101/538272
https://doi.org/10.1101/538272
Autor:
Caterina Missero, Satrajit Sinha, Christian Osterburg, Marco Ferniani, Anna Sirico, Claudia Russo, Sebastian Kehrloesser, Dario Antonini, Birgit Schäfer, Raffaele Ambrosio, Jörg Rinnenthal, Peter Güntert, Julia M. Würz, Volker Dötsch
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 115 (5)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
The p63 gene encodes a master regulator of epidermal commitment, development, and differentiation. Heterozygous mutations in the C-terminal domain of the p63 gene can cause ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome, a life-th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e3d0c7af049e664ab6a9939e41007b0
https://www.repository.cam.ac.uk/handle/1810/279044
https://www.repository.cam.ac.uk/handle/1810/279044
Publikováno v:
Modern Magnetic Resonance ISBN: 9783319282756
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6789fcf488854a993a3f7fec32aa4d3c
https://doi.org/10.1007/978-3-319-28388-3_32
https://doi.org/10.1007/978-3-319-28388-3_32
Publikováno v:
Archives of biochemistry and biophysics. 628
NMR spectra analysis for protein structure determination can now in many cases be performed by automated computational methods. This overview of the computational methods for NMR protein structure analysis presents recent automated methods for signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f84524eb7de87498234427b74f5915
https://pubmed.ncbi.nlm.nih.gov/28263718
https://pubmed.ncbi.nlm.nih.gov/28263718
Publikováno v:
Journal of Physics: Conference Series, 1036 (1)
High-resolution solution-state NMR spectroscopy studies of large proteins typically require uniform deuteration of the system and selective protonation and isotope labelling of methyl groups. Under such circumstances, the assignment of methyl resonan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d910ec4e60f5276d1fc8af35f3e97eb
https://doi.org/10.1088/1742-6596/1036/1/012008
https://doi.org/10.1088/1742-6596/1036/1/012008