Experimental vaccination by single dose sporozoite injection of blood-stage attenuated malaria parasites

Autor: Julia M Sattler, Lukas Keiber, Aiman Abdelrahim, Xinyu Zheng, Martin Jäcklin, Luisa Zechel, Catherine A Moreau, Smilla Steinbrück, Manuel Fischer, Chris J Janse, Angelika Hoffmann, Franziska Hentzschel, Friedrich Frischknecht

Publikováno v: EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2060-2079 (2024)

Abstract Malaria vaccination approaches using live Plasmodium parasites are currently explored, with either attenuated mosquito-derived sporozoites or attenuated blood-stage parasites. Both approaches would profit from the availability of attenuated

Externí odkaz: https://doaj.org/article/7e8f8d388dbf473180a7d3d030a19d8f

The Actin Filament-Binding Protein Coronin Regulates Motility in Plasmodium Sporozoites.

Autor: Kartik S Bane, Simone Lepper, Jessica Kehrer, Julia M Sattler, Mirko Singer, Miriam Reinig, Dennis Klug, Kirsten Heiss, Jake Baum, Ann-Kristin Mueller, Friedrich Frischknecht

Publikováno v: PLoS Pathogens, Vol 12, Iss 7, p e1005710 (2016)

Parasites causing malaria need to migrate in order to penetrate tissue barriers and enter host cells. Here we show that the actin filament-binding protein coronin regulates gliding motility in Plasmodium berghei sporozoites, the highly motile forms o

Externí odkaz: https://doaj.org/article/4dedf6d7420c4c4fafc10a887f9ad6ff

Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP

Autor: Chafen Lu, Dennis Klug, Léanne Strauss, Friedrich Frischknecht, Jessica Kehrer, Timothy A. Springer, Sarah Goellner, Julia M. Sattler, Mirko Singer

Publikováno v: eLife, Vol 9 (2020)
eLife

Inserted (I) domains function as ligand-binding domains in adhesins that support cell adhesion and migration in many eukaryotic phyla. These adhesins include integrin αβ heterodimers in metazoans and single subunit transmembrane proteins in apicomp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b726c0bc7a60afc41c48622dcd1d07
https://doi.org/10.7554/elife.57572

Gliding motility protein LIMP promotes optimal mosquito midgut traversal and infection by Plasmodium berghei

Autor: Julia M. Sattler, Saskia Egarter, Jessica Kehrer, Jorge M. Santos, Gunnar R. Mair, Friedrich Frischknecht

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Molecular and biochemical parasitology

© 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Substrate-dependent gliding motility is key to malaria transmission. It mediates ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8febbaa65913eb7907f6e313fa79cd4a
https://doi.org/10.1016/j.molbiopara.2020.111347

Immunization efficacy of cryopreserved genetically attenuated Plasmodium berghei sporozoites

Autor: John H. Adams, Julia M. Sattler, Alison Roth, Friedrich Frischknecht, Johanna Ripp, Henriette L Prinz

Publikováno v: Parasitology research. 117(8)

Malaria is transmitted through the injection of Plasmodium sporozoites into the skin by Anopheles mosquitoes. The parasites first replicate within the liver before infecting red blood cells, which leads to the symptoms of the disease. Experimental im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::719ae88e81c6f4e1daceda5db060089d
https://pubmed.ncbi.nlm.nih.gov/29797085