Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Julia M. Nielsen"'
Autor:
Chang Liu, Jun Zhang, Wilson Z. Shou, Julia M. Nielsen, Yong Zhang, Harold N. Weller, Tom Covey, Shu Li
Publikováno v:
SLAS technology. 26(2)
High-throughput analysis of compound dissolved in DMSO and arrayed in multiwell plates for quality control (QC) purposes has widespread utility in drug discovery, ranging from the QC of assay-ready plates dispatched by compound management, to compoun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bf8a96fc203a115ac0595cdafc5bc3d
https://pubmed.ncbi.nlm.nih.gov/33196338
https://pubmed.ncbi.nlm.nih.gov/33196338
Autor:
Neha Surti, Jonathan Lippy, Samuel Gerritz, David G. Harden, Peter Chase, Jefferson Chin, Julia M. Nielsen, Harold N. Weller, R. Michael Lawrence, Wilson Z. Shou, Darshani Weerakoon
Publikováno v:
SLAS discovery : advancing life sciences RD. 26(2)
Hits from high-throughput screening (HTS) assays are typically evaluated using cheminformatics and/or empirical approaches before a decision for follow-up (activity confirmation and/or sample resynthesis) is made. However, the compound integrity (i.e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c60028ac212de1108d34666138b183b
https://pubmed.ncbi.nlm.nih.gov/32400264
https://pubmed.ncbi.nlm.nih.gov/32400264
Autor:
Julia M. Nielsen, Jennifer McDonald, Dmitry Zuev, Megan Hayes, Eric Wexler, Joanne J. Bronson, Henry Wong, Yu-Wen Li, Nicholas J. Lodge, John E. Macor, Jeffrey A. Deskus, James E. Grace, Hong Huang, Gail K. Mattson, Mary Guaraldi, Derek J. Denhart, David C. Onthank, Vijay T. Ahuja, Heidi Dulac, Michael F. Parker, Larisa Zueva, Douglas D. Dischino, Ronald J. Mattson, Thaddeus F. Molski, Michael Azure, Jonathan L. Ditta, Richard A. Hartz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6651-6655
Based on a favorable balance between CRF-R1 affinity, lipophilicity and metabolic stability, compound 10 was evaluated for potential development as PET radioligand. Compound [18F]10 was prepared with high radiochemical purity and showed promising bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e68bd4acd3bac602acb56267c782afe
https://doi.org/10.1016/j.bmcl.2012.08.112
https://doi.org/10.1016/j.bmcl.2012.08.112
Autor:
Hong Huang, Nicholas J. Lodge, John E. Macor, Ronald J. Mattson, Edward S. Kozlowski, Gail K. Mattson, Xiaohua Stella Huang, Julia M. Nielsen, Qi Gao, Joanne J. Bronson, Dedong Wu, Dmitry Zuev, Larisa Zueva
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2484-2488
A series of N-fluoroalkyl-8-(6-methoxy-2-methylpyridin-3-yl)-2,7-dimethyl-N-alkylpyrazolo[1,5-a][1,3,5]triazin-4-amines were prepared and evaluated as potential CRF(1)R PET imaging agents. Optimization of their CRF(1)R binding potencies and octanol-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4869c599938ee98aa77c62d9eb7ee820
https://doi.org/10.1016/j.bmcl.2011.02.050
https://doi.org/10.1016/j.bmcl.2011.02.050
Autor:
Nicholas J. Lodge, Dmitry Zuev, John E. Macor, Julia M. Nielsen, Gail K. Mattson, Hong Huang, Richard A. Hartz, Joanne J. Bronson, Ronald J. Mattson, Edward S. Kozlowski, Vijay T. Ahuja, Larisa Zueva, Derek J. Denhart, Jonathan L. Ditta
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(7)
A series of pyrazinones were prepared and evaluated as potential CRF1R PET imaging agents. Optimization of their CRF1R binding potencies and octanol–phosphate buffer phase distribution coefficients are discussed herein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::938e121e6c60f399a8b06c9688414329
https://pubmed.ncbi.nlm.nih.gov/23465610
https://pubmed.ncbi.nlm.nih.gov/23465610