Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Julia M W, Gee"'
Autor:
Jodi M. Saunus, Xavier M. De Luca, Korinne Northwood, Ashwini Raghavendra, Alexander Hasson, Amy E. McCart Reed, Malcolm Lim, Samir Lal, A. Cristina Vargas, Jamie R. Kutasovic, Andrew J. Dalley, Mariska Miranda, Emarene Kalaw, Priyakshi Kalita-de Croft, Irma Gresshoff, Fares Al-Ejeh, Julia M. W. Gee, Chris Ormandy, Kum Kum Khanna, Jonathan Beesley, Georgia Chenevix-Trench, Andrew R. Green, Emad A. Rakha, Ian O. Ellis, Dan V. Nicolau, Peter T. Simpson, Sunil R. Lakhani
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-16 (2022)
Abstract Intratumoral heterogeneity is caused by genomic instability and phenotypic plasticity, but how these features co-evolve remains unclear. SOX10 is a neural crest stem cell (NCSC) specifier and candidate mediator of phenotypic plasticity in ca
Externí odkaz:
https://doaj.org/article/8a3be3a876b24ea3b406d64dc3b52fe6
Autor:
Joanna Achinger-Kawecka, Fatima Valdes-Mora, Phuc-Loi Luu, Katherine A. Giles, C. Elizabeth Caldon, Wenjia Qu, Shalima Nair, Sebastian Soto, Warwick J. Locke, Nicole S. Yeo-Teh, Cathryn M. Gould, Qian Du, Grady C. Smith, Irene R. Ramos, Kristine F. Fernandez, Dave S. Hoon, Julia M. W. Gee, Clare Stirzaker, Susan J. Clark
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Endocrine therapy resistance occurs often in estrogen receptor positive (ER+) breast cancer. Here, the authors find that 3D epigenome remodelling at ER-bound enhancer-promoter interactions is a key mechanism underlying endocrine resistance.
Externí odkaz:
https://doaj.org/article/fa0958eacf7f42d19237b40a66d1a2d1
Autor:
Samuel, Jones, Georgia, Farr, Thirayost, Nimmanon, Silvia, Ziliotto, Julia M W, Gee, Kathryn M, Taylor
Aim:\ud\udZinc is a key secondary messenger that can regulate multiple signalling pathways within cancer cells, thus its levels need to be strictly controlled. The Zrt, Irt-like protein (ZIP, SLC39A) family of zinc transporters increase cytosolic zin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87254ce623f006de5573afee324ca7e1
https://orca.cardiff.ac.uk/id/eprint/149950/1/100280.pdf
https://orca.cardiff.ac.uk/id/eprint/149950/1/100280.pdf
Autor:
David Gallego-Ortega, Anita Ledger, Daniel L Roden, Andrew M K Law, Astrid Magenau, Zoya Kikhtyak, Christina Cho, Stephanie L Allerdice, Heather J Lee, Fatima Valdes-Mora, David Herrmann, Robert Salomon, Adelaide I J Young, Brian Y Lee, C Marcelo Sergio, Warren Kaplan, Catherine Piggin, James R W Conway, Brian Rabinovich, Ewan K A Millar, Samantha R Oakes, Tatyana Chtanova, Alexander Swarbrick, Matthew J Naylor, Sandra O'Toole, Andrew R Green, Paul Timpson, Julia M W Gee, Ian O Ellis, Susan J Clark, Christopher J Ormandy
Publikováno v:
PLoS Biology, Vol 13, Iss 12, p e1002330 (2015)
During pregnancy, the ETS transcription factor ELF5 establishes the milk-secreting alveolar cell lineage by driving a cell fate decision of the mammary luminal progenitor cell. In breast cancer, ELF5 is a key transcriptional determinant of tumor subt
Externí odkaz:
https://doaj.org/article/eb537bc34b10404fbde06ea888ba833f
Autor:
Iain R. Hutcheson, Janice M. Knowlden, Steve E. Hiscox, Denise Barrow, Julia M. W. Gee, John F. Robertson, Ian O. Ellis, Robert I. Nicholson
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-1 (2018)
After the publication of this work [1], an error was noticed in Fig. 2b and Fig. 4b as well as Fig. 4b. and Fig. 5d. Images of the ERK1/2 blots were accidentally duplicated. In Fig. 5a. and Fig. 5c., the last lane for p-ERK1/2 was mistakenly cropped
Externí odkaz:
https://doaj.org/article/e5632994ad1b4bb7b95da4d0548fb586
Autor:
Maria Kalyuga, David Gallego-Ortega, Heather J Lee, Daniel L Roden, Mark J Cowley, C Elizabeth Caldon, Andrew Stone, Stephanie L Allerdice, Fatima Valdes-Mora, Rosalind Launchbury, Aaron L Statham, Nicola Armstrong, M Chehani Alles, Adelaide Young, Andrea Egger, Wendy Au, Catherine L Piggin, Cara J Evans, Anita Ledger, Tilman Brummer, Samantha R Oakes, Warren Kaplan, Julia M W Gee, Robert I Nicholson, Robert L Sutherland, Alexander Swarbrick, Matthew J Naylor, Susan J Clark, Jason S Carroll, Christopher J Ormandy
Publikováno v:
PLoS Biology, Vol 10, Iss 12, p e1001461 (2012)
We have previously shown that during pregnancy the E-twenty-six (ETS) transcription factor ELF5 directs the differentiation of mammary progenitor cells toward the estrogen receptor (ER)-negative and milk producing cell lineage, raising the possibilit
Externí odkaz:
https://doaj.org/article/7e94d3be63174fc88be2581b9f7d3521
Autor:
Andrew Stone, Fatima Valdés-Mora, Julia M W Gee, Lynne Farrow, Richard A McClelland, Heidi Fiegl, Carol Dutkowski, Rachael A McCloy, Robert L Sutherland, Elizabeth A Musgrove, Robert I Nicholson
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40466 (2012)
In the present study, we have taken the novel approach of using an in vitro model representative of tamoxifen-withdrawal subsequent to clinical relapse to achieve a greater understanding of the mechanisms that serve to maintain the resistant-cell phe
Externí odkaz:
https://doaj.org/article/49747edf50f6468d8148b0531767ac77
Autor:
John F R, Robertson, Robert E, Coleman, Kwok-Leung, Cheung, Abigail, Evans, Chris, Holcombe, Anthony, Skene, Daniel, Rea, Samreen, Ahmed, Ali, Jahan, Kieran, Horgan, Petra, Rauchhaus, Roberta, Littleford, S Y Amy, Cheung, Marie, Cullberg, Elza C, de Bruin, Loumpiana, Koulai, Justin P O, Lindemann, Martin, Pass, Paul, Rugman, Gaia, Schiavon, Rahul, Deb, Pauline, Finlay, Andrew, Foxley, Julia M W, Gee
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 26(7)
The STAKT study examined short-term exposure (4.5 days) to the oral selective pan-AKT inhibitor capivasertib (AZD5363) to determine if this drug can reach its therapeutic target in sufficient concentration to significantly modulate key biomarkers of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::3a399b61dedcefcdc40a05da71cadb65
https://pubmed.ncbi.nlm.nih.gov/31836609
https://pubmed.ncbi.nlm.nih.gov/31836609
Autor:
Silvia, Ziliotto, Julia M W, Gee, Ian O, Ellis, Andrew R, Green, Pauline, Finlay, Anna, Gobbato, Kathryn M, Taylor
Publikováno v:
Metallomics
Zinc transporter ZIP7 activates key downstream signalling pathways and is correlated with important clinicopathological parameters that are associated with endocrine resistance.
ZIP7, a member of the ZIP family of zinc importers, resides on the
ZIP7, a member of the ZIP family of zinc importers, resides on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::729eab66f67dafdd64cd217370ddd3c1
https://pubmed.ncbi.nlm.nih.gov/31483418
https://pubmed.ncbi.nlm.nih.gov/31483418
Autor:
Amit, Agrawal, John F R, Robertson, Kwok L, Cheung, Eleanor, Gutteridge, Ian O, Ellis, Robert I, Nicholson, Julia M W, Gee
Publikováno v:
International Journal of Cancer
We report the first study of the biological effect of fulvestrant on ER positive clinical breast cancer using sequential biopsies through to progression. Thirty‐two locally/systemically advanced breast cancers treated with first‐line fulvestrant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5e4fdaf6cf577f1ae26f633ca754e633
https://pubmed.ncbi.nlm.nih.gov/26178788
https://pubmed.ncbi.nlm.nih.gov/26178788