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of 26
pro vyhledávání: '"Julia M Flynn"'
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Autor:
Julia M Flynn, Neha Samant, Gily Schneider-Nachum, David T Barkan, Nese Kurt Yilmaz, Celia A Schiffer, Stephanie A Moquin, Dustin Dovala, Daniel NA Bolon
Publikováno v:
eLife, Vol 11 (2022)
With the continual evolution of new strains of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that are more virulent, transmissible, and able to evade current vaccines, there is an urgent need for effective anti-viral drugs. The SARS-Co
Externí odkaz:
https://doaj.org/article/1d6d9ed5a9a3431a897dfc2f4cfe6b4b
Autor:
Julia M Flynn, Ammeret Rossouw, Pamela Cote-Hammarlof, Inês Fragata, David Mavor, Carl Hollins III, Claudia Bank, Daniel NA Bolon
Publikováno v:
eLife, Vol 9 (2020)
Gene-environment interactions have long been theorized to influence molecular evolution. However, the environmental dependence of most mutations remains unknown. Using deep mutational scanning, we engineered yeast with all 44,604 single codon changes
Externí odkaz:
https://doaj.org/article/8fbe9ee59bee453cbbc15edf81c0d8c2
Autor:
Julia M. Flynn, Qiu Yu J. Huang, Sarah N. Zvornicanin, Gily Schneider-Nachum, Ala M. Shaqra, Nese Kurt Yilmaz, Stephanie A. Moquin, Dustin Dovala, Celia A. Schiffer, Daniel N.A. Bolon
Drugs that target the main protease (Mpro) of SARS-CoV-2 are effective therapeutics that have entered clinical use. Wide-scale use of these drugs will apply selection pressure for the evolution of resistance mutations. To understand resistance potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7711be1bb8dfcd376640c160705a31c0
https://doi.org/10.1101/2023.03.02.530652
https://doi.org/10.1101/2023.03.02.530652
Autor:
Julia M Flynn, Neha Samant, Gily Schneider-Nachum, David T Barkan, Nese Kurt Yilmaz, Celia A Schiffer, Stephanie A Moquin, Dustin Dovala, Daniel NA Bolon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1623ed609f1f7a16a3f9bdbef949f996
https://doi.org/10.7554/elife.77433.sa2
https://doi.org/10.7554/elife.77433.sa2
Autor:
Christopher J.P. Mathy, Parul Mishra, Julia M. Flynn, Tina Perica, David Mavor, Daniel N.A. Bolon, Tanja Kortemme
Allosteric regulation is central to protein function in cellular networks1. However, despite technological advances2,3 most studies of allosteric effects on function are conducted in heterologous environments2,4,5, limiting the discovery of allosteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f5e98ca0ccc901d8927ed882a7649a4
https://doi.org/10.1101/2022.04.13.488230
https://doi.org/10.1101/2022.04.13.488230
Autor:
Inês Fragata, Claudia Bank, Pamela A. Cote-Hammarlof, Konstantin B. Zeldovich, Julia M. Flynn, David Mavor, Daniel N. Bolon
Publikováno v:
Molecular Biology and Evolution
bioRxiv
Cote-Hammarlof, Pamela A; Fragata, Inês; Flynn, Julia; Mavor, David; Zeldovich, Konstantin B; Bank, Claudia; Bolon, Daniel N A (2021). The Adaptive Potential of the Middle Domain of Yeast Hsp90. Molecular Biology and Evolution, 38(2), pp. 368-379. Oxford University Press 10.1093/molbev/msaa211
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
bioRxiv
Cote-Hammarlof, Pamela A; Fragata, Inês; Flynn, Julia; Mavor, David; Zeldovich, Konstantin B; Bank, Claudia; Bolon, Daniel N A (2021). The Adaptive Potential of the Middle Domain of Yeast Hsp90. Molecular Biology and Evolution, 38(2), pp. 368-379. Oxford University Press 10.1093/molbev/msaa211
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The distribution of fitness effects (DFEs) of new mutations across different environments quantifies the potential for adaptation in a given environment and its cost in others. So far, results regarding the cost of adaptation across environments have
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
Autor:
Julia M. Flynn, Neha Samant, Gily Schneider-Nachum, David T. Barkan, Nese Kurt Yilmaz, Celia A. Schiffer, Stephanie A. Moquin, Dustin Dovala, Daniel N.A. Bolon
With the continual evolution of new strains of SARS-CoV-2 that are more virulent, transmissible, and able to evade current vaccines, there is an urgent need for effective anti-viral drugs. SARS-CoV-2 main protease (Mpro) is a leading target for drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a93a1c1dca91581037672ab47ce9365
https://doi.org/10.1101/2022.01.26.477860
https://doi.org/10.1101/2022.01.26.477860
Autor:
Claudia Bank, Daniel N. Bolon, Julia M. Flynn, David Mavor, Carl Hollins, Inês Fragata, Pamela A. Cote-Hammarlof, Ammeret Rossouw
Publikováno v:
eLife, Vol 9 (2020)
eLife
Flynn, Julia M; Rossouw, Ammeret; Cote-Hammarlof, Pamela; Fragata, Inês; Mavor, David; Hollins, Carl; Bank, Claudia; Bolon, Daniel NA (2020). Comprehensive fitness maps of Hsp90 show widespread environmental dependence. eLife, 9 eLife Sciences Publications 10.7554/eLife.53810
eLife
Flynn, Julia M; Rossouw, Ammeret; Cote-Hammarlof, Pamela; Fragata, Inês; Mavor, David; Hollins, Carl; Bank, Claudia; Bolon, Daniel NA (2020). Comprehensive fitness maps of Hsp90 show widespread environmental dependence. eLife, 9 eLife Sciences Publications 10.7554/eLife.53810
Gene-environment interactions have long been theorized to influence molecular evolution. However, the environmental dependence of most mutations remains unknown. Using deep mutational scanning, we engineered yeast with all 44,604 single codon changes
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 588-598 (2016)
SummaryTo probe the mechanism of the Hsp90 chaperone that is required for the maturation of many signaling proteins in eukaryotes, we analyzed the effects of all individual amino acid changes in the ATPase domain on yeast growth rate. The sensitivity