Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Julia Lorenzo"'
Autor:
Carolina Casagualda, Alba López-Moral, Paula Alfonso-Triguero, Julia Lorenzo, Ramon Alibés, Félix Busqué, Daniel Ruiz-Molina
Publikováno v:
Biomimetics, Vol 9, Iss 9, p 531 (2024)
Nanoparticles (NPs) are receiving increasing interest in biomedical applications. However, due to their large surface area, in physiological environments, they tend to interact with plasma proteins, inducing their agglomeration and ultimately resulti
Externí odkaz:
https://doaj.org/article/ef85387a9abd40cbb1f0bc7c71a25e1a
Autor:
Quim Peña, Sergi Rodríguez-Calado, A. Jalila Simaan, Mercè Capdevila, Pau Bayón, Oscar Palacios, Julia Lorenzo, Olga Iranzo
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Metal-based chemotherapeutics like cisplatin are widely employed in cancer treatment. In the last years, the design of redox-active (transition) metal complexes, such as of copper (Cu), has attracted high interest as alternatives to overcome platinum
Externí odkaz:
https://doaj.org/article/2ac498bd2c4d49ca800cae2d859fa6e2
Autor:
Paula Alfonso-Triguero, Julia Lorenzo, Ana Paula Candiota, Carles Arús, Daniel Ruiz-Molina, Fernando Novio
Publikováno v:
Nanomaterials, Vol 13, Iss 10, p 1619 (2023)
Current therapies for treating Glioblastoma (GB), and brain tumours in general, are inefficient and represent numerous challenges. In addition to surgical resection, chemotherapy and radiotherapy are presently used as standards of care. However, trea
Externí odkaz:
https://doaj.org/article/6fd0f54afbb346ba9deddff071f55a36
Autor:
Gonçalo A. Marcelo, David Montpeyó, Joana Galhano, Ramón Martínez-Máñez, José Luis Capelo-Martínez, Julia Lorenzo, Carlos Lodeiro, Elisabete Oliveira
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6612 (2023)
The need for non-invasive therapies capable of conserving drug efficiency and stability while having specific targetability against colorectal cancer (CRC), has made nanoparticles preferable vehicles and principal building blocks for the development
Externí odkaz:
https://doaj.org/article/914729d613f141ea937282fb9bec91a8
Autor:
Gianni Ciofani, Marco Campisi, Clara Mattu, Roger D Kamm, Valeria Chiono, Aji Alex Moothedathu Raynold, João S Freitas, Eugenio Redolfi Riva, Silvestro Micera, Carlotta Pucci, Fernando Novio, Julia Lorenzo, Daniel Ruiz-Molina, Giulia Sierri, Francesca Re, Hannah Wunderlich, Prachi Kumari, Kristen L Kozielski, Mounia Chami, Attilio Marino, Lino Ferreira
Publikováno v:
JPhys Materials, Vol 6, Iss 2, p 022501 (2023)
In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially ef
Externí odkaz:
https://doaj.org/article/9da4fecbbd22429e81d7f68b78a088d2
Autor:
Sergi Rodriguez-Calado, Petra Van Damme, Francesc Xavier Avilés, Ana Paula Candiota, Sebastian Tanco, Julia Lorenzo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1273 (2023)
The cytosolic carboxypeptidase 6 (CCP6) catalyzes the deglutamylation of polyglutamate side chains, a post-translational modification that affects proteins such as tubulins or nucleosome assembly proteins. CCP6 is involved in several cell processes,
Externí odkaz:
https://doaj.org/article/30c6e0dd83a8425d921cd480feaae21d
Publikováno v:
Pharmaceutics, Vol 14, Iss 10, p 2138 (2022)
The yields of soluble ECM proteins recombinantly produced with mammalian cells can be significantly enhanced by exploiting the stabilizing properties of heparin. Here, we propose a simple and straightforward scalable protocol for the mammalian cell p
Externí odkaz:
https://doaj.org/article/877e0d250a7146a5b7a404ccca3a261b
Autor:
Xiaoman Mao, Pilar Calero-Pérez, David Montpeyó, Jordi Bruna, Victor J. Yuste, Ana Paula Candiota, Julia Lorenzo, Fernando Novio, Daniel Ruiz-Molina
Publikováno v:
Nanomaterials, Vol 12, Iss 7, p 1221 (2022)
Cisplatin has been described as a potent anticancer agent for decades. However, in the case of glioblastomas, it is only considered a rescue treatment applied after the failure of second-line treatments. Herein, based on the versatility offered by co
Externí odkaz:
https://doaj.org/article/579be2546ab745b4ae742749793eac95
Autor:
Jamila Djafari, Javier Fernández-Lodeiro, Hugo M. Santos, Julia Lorenzo, Sergi Rodriguez-Calado, Emilia Bértolo, José Luis Capelo-Martínez, Carlos Lodeiro
Publikováno v:
Materials, Vol 13, Iss 23, p 5309 (2020)
Non-viral gene delivery using exogenous microRNAs is a potential strategy for fighting cancers with poor prognosis and which lack specific therapies, such as triple-negative breast cancer (TNBC). Herein we report the synthesis of six nontoxic electro
Externí odkaz:
https://doaj.org/article/6da8d017fd8f438d89b20635808a6596
Autor:
Javier Garcia-Pardo, Sebastian Tanco, Maria C. Garcia-Guerrero, Sayani Dasgupta, Francesc Xavier Avilés, Julia Lorenzo, Lloyd D. Fricker
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 22, p 8687 (2020)
Metallocarboxypeptidase Z (CPZ) is a secreted enzyme that is distinguished from all other members of the M14 metallocarboxypeptidase family by the presence of an N-terminal cysteine-rich Frizzled-like (Fz) domain that binds Wnt proteins. Here, we pre
Externí odkaz:
https://doaj.org/article/c221af52bb1f4c62aa74e8a17b9b3f6c