Výsledky vyhledávání - "Julia Ling-Yu Chen"

Akademický článek

Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.

Autor: Julia Ling-Yu Chen, Daniel Merl, Christopher W Peterson, Jianli Wu, Patrick Yantyng Liu, Hanwei Yin, Deborah M Muoio, Don E Ayer, Mike West, Jen-Tsan Chi

Publikováno v: PLoS Genetics, Vol 6, Iss 9, p e1001093 (2010)

Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional responses of breast ca

Externí odkaz: https://doaj.org/article/63b1b63381834dcca4325d2a5db10c33

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Akademický článek

Cross-study projections of genomic biomarkers: an evaluation in cancer genomics.

Autor: Joseph E Lucas, Carlos M Carvalho, Julia Ling-Yu Chen, Jen-Tsan Chi, Mike West

Publikováno v: PLoS ONE, Vol 4, Iss 2, p e4523 (2009)

Human disease studies using DNA microarrays in both clinical/observational and experimental/controlled studies are having increasing impact on our understanding of the complexity of human diseases. A fundamental concept is the use of gene expression

Externí odkaz: https://doaj.org/article/2fa62723eb1d4f3fa41187d92a8d558f

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Akademický článek

The genomic analysis of lactic acidosis and acidosis response in human cancers.

Autor: Julia Ling-Yu Chen, Joseph E Lucas, Thies Schroeder, Seiichi Mori, Jianli Wu, Joseph Nevins, Mark Dewhirst, Mike West, Jen-Tsan Chi

Publikováno v: PLoS Genetics, Vol 4, Iss 12, p e1000293 (2008)

The tumor microenvironment has a significant impact on tumor development. Two important determinants in this environment are hypoxia and lactic acidosis. Although lactic acidosis has long been recognized as an important factor in cancer, relatively l

Externí odkaz: https://doaj.org/article/23fd5bbd06b848649aaed526c6b8b8ae

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