Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Julia Lieske"'
Autor:
Patrick Y. A. Reinke, Robin Schubert, Dominik Oberthür, Marina Galchenkova, Aida Rahmani Mashhour, Sebastian Günther, Anaïs Chretien, Adam Round, Brandon Charles Seychell, Brenna Norton-Baker, Chan Kim, Christina Schmidt, Faisal H. M. Koua, Alexandra Tolstikova, Wiebke Ewert, Gisel Esperanza Peña Murillo, Grant Mills, Henry Kirkwood, Hévila Brognaro, Huijong Han, Jayanath Koliyadu, Joachim Schulz, Johan Bielecki, Julia Lieske, Julia Maracke, Juraj Knoska, Kristina Lorenzen, Lea Brings, Marcin Sikorski, Marco Kloos, Mohammad Vakili, Patrik Vagovic, Philipp Middendorf, Raphael de Wijn, Richard Bean, Romain Letrun, Seonghyun Han, Sven Falke, Tian Geng, Tokushi Sato, Vasundara Srinivasan, Yoonhee Kim, Oleksandr M. Yefanov, Luca Gelisio, Tobias Beck, Andrew S. Doré, Adrian P. Mancuso, Christian Betzel, Saša Bajt, Lars Redecke, Henry N. Chapman, Alke Meents, Dušan Turk, Winfried Hinrichs, Thomas J. Lane
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-10 (2024)
Abstract The main protease (Mpro) of SARS-CoV-2 is critical for viral function and a key drug target. Mpro is only active when reduced; turnover ceases upon oxidation but is restored by re-reduction. This suggests the system has evolved to survive pe
Externí odkaz:
https://doaj.org/article/7a737b71ae764265a7f11a3df650ea0b
Autor:
Patrick Y. A. Reinke, Edmarcia Elisa de Souza, Sebastian Günther, Sven Falke, Julia Lieske, Wiebke Ewert, Jure Loboda, Alexander Herrmann, Aida Rahmani Mashhour, Katarina Karničar, Aleksandra Usenik, Nataša Lindič, Andreja Sekirnik, Viviane Fongaro Botosso, Gláucia Maria Machado Santelli, Josana Kapronezai, Marcelo Valdemir de Araújo, Taiana Tainá Silva-Pereira, Antônio Francisco de Souza Filho, Mariana Silva Tavares, Lizdany Flórez-Álvarez, Danielle Bruna Leal de Oliveira, Edison Luiz Durigon, Paula Roberta Giaretta, Marcos Bryan Heinemann, Maurice Hauser, Brandon Seychell, Hendrik Böhler, Wioletta Rut, Marcin Drag, Tobias Beck, Russell Cox, Henry N. Chapman, Christian Betzel, Wolfgang Brehm, Winfried Hinrichs, Gregor Ebert, Sharissa L. Latham, Ana Marcia de Sá Guimarães, Dusan Turk, Carsten Wrenger, Alke Meents
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we s
Externí odkaz:
https://doaj.org/article/959ee7d783844cc0965882267049dc4f
Autor:
Vasundara Srinivasan, Hévila Brognaro, Prince R. Prabhu, Edmarcia Elisa de Souza, Sebastian Günther, Patrick Y. A. Reinke, Thomas J. Lane, Helen Ginn, Huijong Han, Wiebke Ewert, Janina Sprenger, Faisal H. M. Koua, Sven Falke, Nadine Werner, Hina Andaleeb, Najeeb Ullah, Bruno Alves Franca, Mengying Wang, Angélica Luana C. Barra, Markus Perbandt, Martin Schwinzer, Christina Schmidt, Lea Brings, Kristina Lorenzen, Robin Schubert, Rafael Rahal Guaragna Machado, Erika Donizette Candido, Danielle Bruna Leal Oliveira, Edison Luiz Durigon, Stephan Niebling, Angelica Struve Garcia, Oleksandr Yefanov, Julia Lieske, Luca Gelisio, Martin Domaracky, Philipp Middendorf, Michael Groessler, Fabian Trost, Marina Galchenkova, Aida Rahmani Mashhour, Sofiane Saouane, Johanna Hakanpää, Markus Wolf, Maria Garcia Alai, Dusan Turk, Arwen R. Pearson, Henry N. Chapman, Winfried Hinrichs, Carsten Wrenger, Alke Meents, Christian Betzel
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
Three natural phenolic compounds are found to bind to an allosteric site in SARS-CoV-2 papain-like protease and exhibit antiviral activity in vitro, showing potential as starting scaffolds for drug design.
Externí odkaz:
https://doaj.org/article/94a6b8437953446b80663a578e6c235a
Autor:
Wiebke Ewert, Sebastian Günther, Francesca Miglioli, Sven Falke, Patrick Y. A. Reinke, Stephan Niebling, Christian Günther, Huijong Han, Vasundara Srinivasan, Hévila Brognaro, Julia Lieske, Kristina Lorenzen, Maria M. Garcia-Alai, Christian Betzel, Mauro Carcelli, Winfried Hinrichs, Dominga Rogolino, Alke Meents
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
The papain-like protease (PLpro) of SARS-CoV-2 is essential for viral propagation and, additionally, dysregulation of the host innate immune system. Using a library of 40 potential metal-chelating compounds we performed an X-ray crystallographic scre
Externí odkaz:
https://doaj.org/article/5abf90b91d214accbdd2fa885322f8ed
Autor:
Julia Lieske, Maximilian Cerv, Stefan Kreida, Dana Komadina, Janine Fischer, Miriam Barthelmess, Pontus Fischer, Tim Pakendorf, Oleksandr Yefanov, Valerio Mariani, Thomas Seine, Breyan H. Ross, Eva Crosas, Olga Lorbeer, Anja Burkhardt, Thomas J. Lane, Sebastian Guenther, Julian Bergtholdt, Silvan Schoen, Susanna Törnroth-Horsefield, Henry N. Chapman, Alke Meents
Publikováno v:
IUCrJ, Vol 6, Iss 4, Pp 714-728 (2019)
Efficient and reliable sample delivery has remained one of the bottlenecks for serial crystallography experiments. Compared with other methods, fixed-target sample delivery offers the advantage of significantly reduced sample consumption and shorter
Externí odkaz:
https://doaj.org/article/9cf038e492ec4349b8a7aa1396ce04ee
Autor:
Kenneth R. Beyerlein, Dennis Dierksmeyer, Valerio Mariani, Manuela Kuhn, Iosifina Sarrou, Angelica Ottaviano, Salah Awel, Juraj Knoska, Silje Fuglerud, Olof Jönsson, Stephan Stern, Max O. Wiedorn, Oleksandr Yefanov, Luigi Adriano, Richard Bean, Anja Burkhardt, Pontus Fischer, Michael Heymann, Daniel A. Horke, Katharina E. J. Jungnickel, Elena Kovaleva, Olga Lorbeer, Markus Metz, Jan Meyer, Andrew Morgan, Kanupriya Pande, Saravanan Panneerselvam, Carolin Seuring, Aleksandra Tolstikova, Julia Lieske, Steve Aplin, Manfred Roessle, Thomas A. White, Henry N. Chapman, Alke Meents, Dominik Oberthuer
Publikováno v:
IUCrJ, Vol 4, Iss 6, Pp 769-777 (2017)
Unravelling the interaction of biological macromolecules with ligands and substrates at high spatial and temporal resolution remains a major challenge in structural biology. The development of serial crystallography methods at X-ray free-electron las
Externí odkaz:
https://doaj.org/article/e490cd1b81b944869066336aa07f9314
Autor:
Patrick Reinke, Edmarcia de Souza, Sebastian Günther, Sven Falke, Julia Lieske, Wiebke Ewert, Jure Loboda, Alexander Herrmann, Aida Rahmani Mashhour, Katarina Karnicar, Aleksandra Usenik, Natasa Lindic, Andreja Sekirnik, Viviane Botosso, Gláucia Machado Santelli, Josana Kapronezai, Marcelo de Araújo, Taiana Silva-Pereira, Antonio Souza Filho, Mariana Tavares, Lizdany Flórez-Álvarez, Danielle Oliveira, Edison Durigon, Paula Giaretta, Marcos Heinemann, Maurice Hauser, Brandon Seychell, Hendrik Böhler, Wioletta Rut, Marcin Drag, Tobias Beck, Russell Cox, Henry Chapman, Christian Betzel, Wolfgang Brehm, Winfried Hinrichs, Gregor Ebert, Sharissa Latham, Ana Marcia Guimarães, Dušan Turk, Carsten Wrenger, Alke Meents
Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (Mpro), its moderate activity in Mpro inhibition assays hints at a second target. Indeed, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a39214aa65c5a9ef54c73b10a0e72cbe
https://doi.org/10.21203/rs.3.rs-2450926/v1
https://doi.org/10.21203/rs.3.rs-2450926/v1
Autor:
Wiebke, Ewert, Sebastian, Günther, Francesca, Miglioli, Sven, Falke, Patrick Y A, Reinke, Stephan, Niebling, Christian, Günther, Huijong, Han, Vasundara, Srinivasan, Hévila, Brognaro, Julia, Lieske, Kristina, Lorenzen, Maria M, Garcia-Alai, Christian, Betzel, Mauro, Carcelli, Winfried, Hinrichs, Dominga, Rogolino, Alke, Meents
Publikováno v:
Frontiers in chemistry. 10
The papain-like protease (PLpro) of SARS-CoV-2 is essential for viral propagation and, additionally, dysregulation of the host innate immune system. Using a library of 40 potential metal-chelating compounds we performed an X-ray crystallographic scre
Autor:
Julia, Lieske, Maximilian, Cerv, Stefan, Kreida, Dana, Komadina, Janine, Fischer, Miriam, Barthelmess, Pontus, Fischer, Tim, Pakendorf, Oleksandr, Yefanov, Valerio, Mariani, Thomas, Seine, Breyan H, Ross, Eva, Crosas, Olga, Lorbeer, Anja, Burkhardt, Thomas J, Lane, Sebastian, Guenther, Julian, Bergtholdt, Silvan, Schoen, Susanna, Törnroth-Horsefield, Henry N, Chapman, Alke, Meents
Publikováno v:
IUCrJ
IUCrJ, Vol 6, Iss 4, Pp 714-728 (2019)
IUCrJ, Vol 6, Iss 4, Pp 714-728 (2019)
Direct protein crystallization on fixed-target sample holders allows highly efficient serial crystallography experiments and ligand-binding studies.
Efficient and reliable sample delivery has remained one of the bottlenecks for serial crystallog
Efficient and reliable sample delivery has remained one of the bottlenecks for serial crystallog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::061af78f91f87763c5bba2b7df2d5a59
https://hdl.handle.net/21.11116/0000-0004-81C2-E21.11116/0000-0004-81C4-C
https://hdl.handle.net/21.11116/0000-0004-81C2-E21.11116/0000-0004-81C4-C