Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Julia L Macisaac"'
Autor:
Elie Antoun, Negusse T Kitaba, Philip Titcombe, Kathryn V Dalrymple, Emma S Garratt, Sheila J Barton, Robert Murray, Paul T Seed, Joanna D Holbrook, Michael S Kobor, David Ts Lin, Julia L MacIsaac, Graham C Burdge, Sara L White, Lucilla Poston, Keith M Godfrey, Karen A Lillycrop, UPBEAT Consortium
Publikováno v:
PLoS Medicine, Vol 17, Iss 11, p e1003229 (2020)
BackgroundHigher maternal plasma glucose (PG) concentrations, even below gestational diabetes mellitus (GDM) thresholds, are associated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism. Here, we examined the rel
Externí odkaz:
https://doaj.org/article/b2fe24c15dd443af8b059bf9123fd7ff
Autor:
Lisa M McEwen, Meaghan J Jones, David Tse Shen Lin, Rachel D Edgar, Lucas T Husquin, Julia L MacIsaac, Katia E Ramadori, Alexander M Morin, Christopher F Rider, Chris Carlsten, Lluís Quintana-Murci, Steve Horvath, Michael S Kobor
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-9 (2018)
Abstract Background The capacity of technologies measuring DNA methylation (DNAm) is rapidly evolving, as are the options for applicable bioinformatics methods. The most commonly used DNAm microarray, the Illumina Infinium HumanMethylation450 (450K a
Externí odkaz:
https://doaj.org/article/c7c9511d89d7403dbd78d2c6ae04b322
Autor:
Xinyi Lin, Jane Yi Lin Tan, Ai Ling Teh, Ives Yubin Lim, Samantha J Liew, Julia L MacIsaac, Yap Seng Chong, Peter D Gluckman, Michael S Kobor, Clara Yujing Cheong, Neerja Karnani
Publikováno v:
Epigenetics, Vol 13, Iss 9, Pp 941-958 (2018)
Accounting for cellular heterogeneity is essential in neonatal epigenome-wide association studies (EWAS) performed on heterogeneous tissues, such as umbilical cord tissue (CT) or cord blood (CB). Using a reference-panel-based statistical approach, th
Externí odkaz:
https://doaj.org/article/ac06332ccbc04069b82860a45024fd24
Autor:
Sarina Abrishamcar, Beryl C. Zhuang, Mara Thomas, Nicole Gladish, Julia L. MacIsaac, Meaghan J. Jones, Elinor Simons, Theo J. Moraes, Piush J. Mandhane, Jeffrey R. Brook, Padmaja Subbarao, Stuart E. Turvey, Edith Chen, Gregory E. Miller, Michael S. Kobor, Anke Hüls
Publikováno v:
Translational Psychiatry, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Maternal stress and depression during pregnancy and the first year of the infant’s life affect a large percentage of mothers. Maternal stress and depression have been associated with adverse fetal and childhood outcomes as well as differen
Externí odkaz:
https://doaj.org/article/04feef9201f24f2b91d0ff2cf9a360b7
Autor:
Ola E. Salama, Nikho Hizon, Melissa Del Vecchio, Kurt Kolsun, Mario A. Fonseca, David T. S. Lin, Oscar Urtatiz, Julia L. MacIsaac, Michael S. Kobor, Elizabeth A. C. Sellers, Vernon W. Dolinsky, Allison B. Dart, Meaghan J. Jones, Brandy A. Wicklow
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Objective Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it is not clear how the two diseases differ at a molecular level. In utero exposure to maternal type 2 diabetes (T2D) is known to be a specific ris
Externí odkaz:
https://doaj.org/article/7bffa8c1e7684ef8bb5927a17a02682a
Autor:
Alexandra K Marr, Julia L MacIsaac, Ruiwei Jiang, Adriana M Airo, Michael S Kobor, W Robert McMaster
Publikováno v:
PLoS Pathogens, Vol 10, Iss 10, p e1004419 (2014)
Infection of macrophages by the intracellular protozoan Leishmania leads to down-regulation of a number of macrophage innate host defense mechanisms, thereby allowing parasite survival and replication. The underlying molecular mechanisms involved rem
Externí odkaz:
https://doaj.org/article/ee44871f10d64f0ebcca5ebacb35e1bb
Autor:
Gillian England-Mason, Sarah M. Merrill, Jiaying Liu, Jonathan W. Martin, Amy M. MacDonald, David W. Kinniburgh, Nicole Gladish, Julia L. MacIsaac, Gerald F. Giesbrecht, Nicole Letourneau, Michael S. Kobor, Deborah Dewey
Publikováno v:
Epigenomes, Vol 8, Iss 3, p 31 (2024)
We examined whether prenatal exposure to two classes of endocrine-disrupting chemicals (EDCs) was associated with infant epigenetic age acceleration (EAA), a DNA methylation biomarker of aging. Participants included 224 maternal–infant pairs from a
Externí odkaz:
https://doaj.org/article/ee0d31bff686479e805e23e999284c77
Autor:
Sarah M. Merrill, Nicole Letourneau, Gerald F. Giesbrecht, Karlie Edwards, Julia L. MacIsaac, Jonathan W. Martin, Amy M. MacDonald, David W. Kinniburgh, Michael S. Kobor, Deborah Dewey, Gillian England-Mason, The APrON Study Team
Publikováno v:
Epigenomes, Vol 8, Iss 1, p 3 (2024)
Di(2-ethylhexyl) phthalate (DEHP) is a common plasticizer that can affect immune system development and susceptibility to infection. Aging processes (measured as epigenetic age acceleration (EAA)) may mediate the immune-related effects of prenatal ex
Externí odkaz:
https://doaj.org/article/7fbe9dcdc50c4de3ac2ac879cca11e96
Autor:
Sumaiya A. Islam, Sarah J. Goodman, Julia L. MacIsaac, Jelena Obradović, Ronald G. Barr, W. Thomas Boyce, Michael S. Kobor
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-18 (2019)
Abstract Background The widespread use of accessible peripheral tissues for epigenetic analyses has prompted increasing interest in the study of tissue-specific DNA methylation (DNAm) variation in human populations. To date, characterizations of inte
Externí odkaz:
https://doaj.org/article/92d90390c31f45e3a3fec54a7f8292d0
Autor:
Alexander M. Morin, Evan Gatev, Lisa M. McEwen, Julia L. MacIsaac, David T. S. Lin, Nastassja Koen, Darina Czamara, Katri Räikkönen, Heather J. Zar, Karestan Koenen, Dan J. Stein, Michael S. Kobor, Meaghan J. Jones
Publikováno v:
Clinical Epigenetics, Vol 9, Iss 1, Pp 1-9 (2017)
Abstract Background Cord blood is a commonly used tissue in environmental, genetic, and epigenetic population studies due to its ready availability and potential to inform on a sensitive period of human development. However, the introduction of mater
Externí odkaz:
https://doaj.org/article/d15db457d2e8414eaff5e76c7319f991