Výsledky vyhledávání - "Julia Kuehnlenz"

Abstract 6089: Identification of novel YAP/TAZ pathway regulators in the triple-negative breast cancer cell line MDA-MB231 using single-cell CRISPR screening

Autor: Mareike Berlak, Zuzanna Makowska, Filippos Klironomos, Julia Kuehnlenz, Atanas Kamburov, Andreas Steffen, Martin Lange, Barbara Nicke, Ralf Lesche, Peter Staller, Charlotte Kopitz, Jan Naujoks

Publikováno v: Cancer Research. 83:6089-6089

The Hippo signaling cascade is a major pathway that integrates a broad spectrum of mechanosensory signals at the plasma membrane and regulates response via control of cell proliferation, self-renewal, differentiation, and apoptosis. Dysregulation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d97e88c3074aa7701ef4af05c2e60d1b
https://doi.org/10.1158/1538-7445.am2023-6089

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Abstract A29: Genome-wide CRISPR/Cas9 screens for the identification of novel YAP1/TAZ modulators

Autor: Lisette Potze, Ekaterina Nevedomskaya, Benjamin Bader, Julia Kuehnlenz, Claudia Luther, Peter Staller, Jan Naujoks, Andreas Steffen, Atanas Kamburov, Anna Anurin, Anne Buttgereit, Ralf Lesche, Barbara Nicke, Stefan Prechtl, Martin Lange

Publikováno v: Molecular Cancer Research. 18:A29-A29

Aberrant activation of the Hippo pathway effectors YAP1/TAZ promotes cell proliferation and tumorigenesis. To identify novel regulators of YAP1/TAZ in cancer, we established a FACS-based screening system monitoring YAP1/TAZ activity in MDA-MB-231 bre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3bd4f7d906a8f01a33b0b5497553b99e
https://doi.org/10.1158/1557-3125.hippo19-a29

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Abstract 3055: Genome-wide CRISPR/Cas9 screen for the identification of novel YAP1/TAZ modulators

Autor: Martin Lange, Jan Naujoks, Ekaterina Nevedomskaya, Anna Anurin, Julia Kuehnlenz, Ralf Lesche, Atanas Kamburov, Andreas Steffen, Lisette Potze, Barbara Nicke

Publikováno v: Cancer Research. 79:3055-3055

Aberrant activation of the Hippo pathway effectors YAP1/TAZ promotes cell proliferation and tumorigenesis. To identify novel regulators of YAP1/TAZ as a possible means to treat cancer, we established a novel, FACS-based screening system monitoring YA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9218007bf9eb8d3e3d02c14e33403473
https://doi.org/10.1158/1538-7445.am2019-3055

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