Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Julia Klopp"'
Autor:
Johanna M Jansen, Charles Wartchow, Wolfgang Jahnke, Susan Fong, Tiffany Tsang, Keith Pfister, Tatiana Zavorotinskaya, Dirksen Bussiere, Jan Marie Cheng, Kenneth Crawford, Yumin Dai, Jeffrey Dove, Eric Fang, Yun Feng, Jean-Michel Florent, John Fuller, Alvar D Gossert, Mohammad Hekmat-Nejad, Chrystèle Henry, Julia Klopp, William P Lenahan, Andreas Lingel, Sylvia Ma, Arndt Meyer, Yuji Mishina, Jamie Narberes, Gwynn Pardee, Savithri Ramurthy, Sebastien Rieffel, Darrin Stuart, Sharadha Subramanian, Laura Tandeske, Stephania Widger, Armin Widmer, Aurelie Winterhalter, Isabel Zaror, Stephen Hardy
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174706 (2017)
RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a novel coupled biochemical assay that measures activation of the effector BRAF by prenylated
Externí odkaz:
https://doaj.org/article/935bc8e9e098406ea024047d133a1803
Autor:
Gabi Schutzius, Michael Faller, Aimee Reynolds, Ralph Tiedt, Julia Klopp, Florian Fuchs, Laure C. Bouchez, Federico Tortelli, Nelly Leroy, Jonathan J. Turner, Guglielmo Roma, Simona Cotesta, Armin Beyerbach, Peter Drueckes, Shola M Richards, Debora Bonenfant, Heinrich Rueeger, Heinz Ruffner, Jutta Blank, Rémi Terranova, Peter Tarsa, Frederic Grandjean, Florian Nigsch, Sebastian Bergling, Natalie Dales, Alexandra Aebi, Paul W. Manley, Markus Schirle, Christian Kolter, Tewis Bouwmeester, Rene Hemmig, Sukhdeep Sahambi, Lori L. Jennings, Walter Carbone, Felix Lohmann, Alfred Zimmerlin, Jun Li, Susan Kirkland, Steffen Renner, Mathias Frederiksen, Vickie Driver, Amy Berwick, Florence Zink, Jason R. Thomas, Andrea Vaupel, Chris Dimitri, Vito Guagnano, Viktoria Gruber, Malvina Louis, Caroline Gubser Keller, Adrian Salathe
Publikováno v:
Nature chemical biology. 17(3)
Although most acute skin wounds heal rapidly, non-healing skin ulcers represent an increasing and substantial unmet medical need that urgently requires effective therapeutics. Keratinocytes resurface wounds to re-establish the epidermal barrier by tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a8580afdc9f2d099758e215f9da05e
https://pubmed.ncbi.nlm.nih.gov/33462495
https://pubmed.ncbi.nlm.nih.gov/33462495
Autor:
Julia Klopp, Daniela Scherer-Becker, Aurélie Winterhalter, Christian Ostermeier, Rémy Gébleux, Alvar D. Gossert
Publikováno v:
Journal of biomolecular NMR. 71(4)
We present protocols for high-level expression of isotope-labelled proteins in E. coli in cost-effective ways. This includes production of large amounts of unlabeled proteins and 13C-methyl methionine labeling in rich media, where yields of up to a g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f0ff2350436e5c3de6cde8dee65474d
https://pubmed.ncbi.nlm.nih.gov/29779067
https://pubmed.ncbi.nlm.nih.gov/29779067
Autor:
Aurélie Winterhalter, Sharadha Subramanian, Tiffany Tsang, Jean-Michel Florent, Stephen F. Hardy, Laura Tandeske, Armin Widmer, Arndt Meyer, Johanna M. Jansen, Charles Wartchow, S. Rieffel, Stephania Widger, Yumin Dai, Tatiana Zavorotinskaya, Savithri Ramurthy, Dove Jeffrey H, Yun Feng, Julia Klopp, Isabel Zaror, Kenneth Crawford, Alvar D. Gossert, Susan Fong, Darrin Stuart, Yuji Mishina, John Fuller, Gwynn Pardee, Andreas Lingel, Lenahan William P, Keith B. Pfister, Mohammad Hekmat-Nejad, Jamie Narberes, Eric Fang, Dirksen E. Bussiere, Sylvia Ma, Wolfgang Jahnke, Jan Marie Cheng, Chrystèle Henry
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174706 (2017)
PLoS ONE, 12 (4)
PLoS ONE
PLoS ONE, 12 (4)
PLoS ONE
RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a novel coupled biochemical assay that measures activation of the effector BRAF by prenylated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74adeb6145df8376b86b98aae0c5870
http://europepmc.org/articles/PMC5383040?pdf=render
http://europepmc.org/articles/PMC5383040?pdf=render
Autor:
Stephanie Guerro-Lagasse, Andreas Marzinzik, Sandra W. Cowan-Jacob, Linda Hinh, César Fernández, Julia Klopp, Alexei S. Karpov, Sabina Pecchi, Inga Galuba, Henrik Möbitz, Sylvia Ma, Kevin Shoemaker, Payman Amiri, Marie-Helene Bellance, Werner Breitenstein, Joerg Trappe, Dylan Daniel, Gabriele Rummel, Mika Lindvall, Charles Voliva, Cornelia Bellamacina, Wolfgang Jahnke, Doriano Fabbro, Sascha Gutmann, Albert Lai, Regis Denay
The discovery of inhibitors targeting novel allosteric kinase sites is very challenging. Such compounds, however, once identified could offer exquisite levels of selectivity across the kinome. Herein we report our structure-based optimization strateg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d26e497abbd399d9317b94bae55a6f
https://europepmc.org/articles/PMC4499825/
https://europepmc.org/articles/PMC4499825/
Autor:
César Fernández, Julia Klopp, Susan Roest, Binesh Shrestha, Agnieszka Sitarska, Lukasz Skora, Alvar D. Gossert
Publikováno v:
Journal of biomolecular NMR. 62(2)
For a wide range of proteins of high interest, the major obstacle for NMR studies is the lack of an affordable eukaryotic expression system for isotope labeling. Here, a simple and affordable protocol is presented to produce uniform labeled proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a50d1f71681ab10a513a8b941d35c69a
https://pubmed.ncbi.nlm.nih.gov/25929326
https://pubmed.ncbi.nlm.nih.gov/25929326
Publikováno v:
Journal of biomolecular NMR. 62(2)
Auto-inducing media for protein expression offer many advantages like robust reproducibility, high yields of soluble protein and much reduced workload. Here, an auto-inducing medium for uniform isotope labelling of proteins with (15)N, (13)C and/or (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48ef49a001195706a79aa63db93d78b
https://pubmed.ncbi.nlm.nih.gov/25893498
https://pubmed.ncbi.nlm.nih.gov/25893498
Autor:
Alvar D. Gossert, Dove Jeffrey H, Sharadha Subramanian, Susan Fong, Bill Lenahan, Gwynn Pardee, Simona Gokhin, Andreas Lingel, Arndt Meyer, Savithri Ramurthy, Laura Tandeske, David Farley, Charles Wartchow, Tatiana Zavorotinskaya, Julia Klopp, John Fuller, Kevin Shoemaker, Eric Fang, Anke Blechschmidt, Yumin Dai, Chrystèle Henry, Isabel Zaror, Dirksen E. Bussiere, Wolfgang Jahnke, Jean-Michel Florent, C. Gregory Paris, Keith B. Pfister, Mohammad Hekmat-Nejad, Jamie Narberes, Johanna M. Jansen, Stephen F. Hardy, Armin Widmer, Stephania Widger, Tiffany Tsang, Paul A. Renhowe, S. Rieffel
Publikováno v:
Molecular Cancer Research. 12:B38-B38
Mutated forms of KRAS are no longer able to switch effectors between “on” and “off” states. It is known that the function of KRAS is controlled by key parts in the C-terminus, including six consecutive lysines, a terminal prenyl moiety and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3da1dadaf490935832bd212e91663a65
https://doi.org/10.1158/1557-3125.rasonc14-b38
https://doi.org/10.1158/1557-3125.rasonc14-b38