Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Julia K. Polansky"'
Autor:
Kristy Ou, Dania Hamo, Anne Schulze, Andy Roemhild, Daniel Kaiser, Gilles Gasparoni, Abdulrahman Salhab, Ghazaleh Zarrinrad, Leila Amini, Stephan Schlickeiser, Mathias Streitz, Jörn Walter, Hans-Dieter Volk, Michael Schmueck-Henneresse, Petra Reinke, Julia K. Polansky
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Adoptive transfer of regulatory T cells (Treg) is a promising new therapeutic option to treat detrimental inflammatory conditions after transplantation and during autoimmune disease. To reach sufficient cell yield for treatment, ex vivo isolated auto
Externí odkaz:
https://doaj.org/article/7b260d54dd1e425b9ebf78e959997007
Autor:
Kim-Long Truong, Stephan Schlickeiser, Katrin Vogt, David Boës, Katarina Stanko, Christine Appelt, Mathias Streitz, Gerald Grütz, Nadja Stobutzki, Christian Meisel, Christina Iwert, Stefan Tomiuk, Julia K. Polansky, Andreas Pascher, Nina Babel, Ulrik Stervbo, Igor Sauer, Undine Gerlach, Birgit Sawitzki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Despite the current human CD4 memory T cell stratification by CD45RA/CCR7, functional heterogeneities still exist within the respective subsets. Here the authors show that several surface markers, including KLRB1, KLRG1, GPR56 and KLRF1, help to furt
Externí odkaz:
https://doaj.org/article/74a94f8ecf9c440db254d28175cce507
Autor:
Christopher Kressler, Gilles Gasparoni, Karl Nordström, Dania Hamo, Abdulrahman Salhab, Christoforos Dimitropoulos, Sascha Tierling, Petra Reinke, Hans-Dieter Volk, Jörn Walter, Alf Hamann, Julia K. Polansky
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
CD4+ regulatory T cells (Tregs) are key mediators of immunological tolerance and promising effector cells for immuno-suppressive adoptive cellular therapy to fight autoimmunity and chronic inflammation. Their functional stability is critical for thei
Externí odkaz:
https://doaj.org/article/d2ea104a2f8548089bd9d3526367794e
Autor:
Abdulrahman Salhab, Karl Nordström, Gilles Gasparoni, Kathrin Kattler, Peter Ebert, Fidel Ramirez, Laura Arrigoni, Fabian Müller, Julia K. Polansky, Cristina Cadenas, Jan G.Hengstler, Thomas Lengauer, Thomas Manke, DEEP Consortium, Jörn Walter
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-13 (2018)
Abstract Background Partially methylated domains are extended regions in the genome exhibiting a reduced average DNA methylation level. They cover gene-poor and transcriptionally inactive regions and tend to be heterochromatic. We present a comprehen
Externí odkaz:
https://doaj.org/article/cec8d3291de344efa45c4a879e94a5c0
Autor:
Sarah Kinkley, Johannes Helmuth, Julia K. Polansky, Ilona Dunkel, Gilles Gasparoni, Sebastian Fröhler, Wei Chen, Jörn Walter, Alf Hamann, Ho-Ryun Chung
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Co-localizing chromatin modifications and regulators can exert a combinatorial effect on chromatin structure and function. Here the authors describe reChIP-seq and normR to identify co-localizing proteins in an unbiased genome-wide manner.
Externí odkaz:
https://doaj.org/article/1c634ef3a9fe46f393d2c13502475665
Autor:
Anna Nowak, Dominik Lock, Petra Bacher, Thordis Hohnstein, Katrin Vogt, Judith Gottfreund, Pascal Giehr, Julia K. Polansky, Birgit Sawitzki, Andrew Kaiser, Jörn Walter, Alexander Scheffold
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Regulatory T cells (Tregs) are an attractive therapeutic tool for several different immune pathologies. Therapeutic Treg application often requires prolonged in vitro culture to generate sufficient Treg numbers or to optimize their functionality, e.g
Externí odkaz:
https://doaj.org/article/e7874dcbe1cb4db2b548ec313aecd489
Autor:
Jérémie D Goldstein, Aude Burlion, Bruno Zaragoza, Kélhia Sendeyo, Julia K Polansky, Jochen Huehn, Eliane Piaggio, Benoit L Salomon, Gilles Marodon
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153682 (2016)
The IL-2/JAK3/STAT-5 signaling pathway is involved on the initiation and maintenance of the transcription factor Foxp3 in regulatory T cells (Treg) and has been associated with demethylation of the intronic Conserved Non Coding Sequence-2 (CNS2). How
Externí odkaz:
https://doaj.org/article/61e67450ddb84f7a9caa313f101a5655
Autor:
Uta Syrbe, Maibritt Mardahl, Sascha Tierling, Christopher Kressler, Julia K. Polansky, Joern Walter, Alf Hamann, Julia Triebus, A Szilagyi, M de Almeida, Stefan Floess, Jochen Huehn, Balint Szilagyi, Pawel Durek
Publikováno v:
Mucosal Immunology. 10:1443-1454
The concept of a "topographical memory" in lymphocytes implies a stable expression of homing receptors mediating trafficking of lymphocytes back to the tissue of initial activation. However, a significant plasticity of the gut-homing receptor α4β7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b1acb62b9584389008b42f63599bdd1
https://doi.org/10.1038/mi.2017.7
https://doi.org/10.1038/mi.2017.7
Autor:
Cristina Cadenas, Wei Chen, Maibritt Mardahl, Karl Nordstroem, Stefan Wallner, Ria Baumgrass, Pawel Durek, Julia K. Polansky, Stefan Floess, Sven Olek, Sascha Tierling, Martin Karl, Boris A. Ratsch, Matthias Pink, Jörn Walter, Uta Syrbe, Alf Hamann, Kathrin Gianmoena
Publikováno v:
The Journal of Immunology. 197:3406-3414
E- and P-selectin ligands (E- and P-ligs) guide effector memory T cells into skin and inflamed regions, mediate the inflammatory recruitment of leukocytes, and contribute to the localization of hematopoietic precursor cells. A better understanding of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50041fd5b359ac44cbd504e940c06f6
https://doi.org/10.4049/jimmunol.1502434
https://doi.org/10.4049/jimmunol.1502434
Autor:
Kim-Long, Truong, Stephan, Schlickeiser, Katrin, Vogt, David, Boës, Katarina, Stanko, Christine, Appelt, Mathias, Streitz, Gerald, Grütz, Nadja, Stobutzki, Christian, Meisel, Christina, Iwert, Stefan, Tomiuk, Julia K, Polansky, Andreas, Pascher, Nina, Babel, Ulrik, Stervbo, Igor, Sauer, Undine, Gerlach, Birgit, Sawitzki
Publikováno v:
Nature Communications
All memory T cells mount an accelerated response on antigen reencounter, but significant functional heterogeneity is present within the respective memory T-cell subsets as defined by CCR7 and CD45RA expression, thereby warranting further stratificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::66c7c9f64768abba0501733fcefa0197
https://pubmed.ncbi.nlm.nih.gov/31118448
https://pubmed.ncbi.nlm.nih.gov/31118448