Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Julia K. Panzer"'
Autor:
Julia K. Panzer, Alejandro Caicedo
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102399- (2023)
Summary: Pancreatic tissue slices allow functional investigations under close physiological conditions in situ. This approach is particularly advantageous for studying infiltrated and structurally damaged islets as found in T1D. More importantly, sli
Externí odkaz:
https://doaj.org/article/53136e340aaf4628b8f2f9d4b9937015
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine an
Externí odkaz:
https://doaj.org/article/e297d8d44f204d96a98c13a905c50452
Autor:
Christian M. Cohrs, Julia K. Panzer, Denise M. Drotar, Stephen J. Enos, Nicole Kipke, Chunguang Chen, Robert Bozsak, Eyke Schöniger, Florian Ehehalt, Marius Distler, Ana Brennand, Stefan R. Bornstein, Jürgen Weitz, Michele Solimena, Stephan Speier
Publikováno v:
Cell Reports, Vol 31, Iss 1, Pp - (2020)
Summary: Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction and mass loss for reduced insulin levels in type 2 diabe
Externí odkaz:
https://doaj.org/article/74611d8ea8d3455cb3cb7f860abbdb27
Autor:
Mirza Muhammad Fahd Qadir, Silvia Álvarez-Cubela, Jonathan Weitz, Julia K. Panzer, Dagmar Klein, Yaisa Moreno-Hernández, Sirlene Cechin, Alejandro Tamayo, Joana Almaça, Helmut Hiller, Maria Beery, Irina Kusmartseva, Mark Atkinson, Stephan Speier, Camillo Ricordi, Alberto Pugliese, Alejandro Caicedo, Christopher A. Fraker, Ricardo Luis Pastori, Juan Domínguez-Bendala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/2a1cc15a96f04c4e9605fe345f65874d
Publikováno v:
Diabetes. 72:769-780
Low-dose IL-2 is a promising immunotherapy in clinical trials for treating type 1 diabetes. A new IL-2 analog, IL-2/CD25 fusion protein, has been shown to more efficiently delay or prevent diabetes in NOD mice by expanding the population of activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86f8204c3c60e07ee261def225450c77
https://doi.org/10.2337/db22-0482
https://doi.org/10.2337/db22-0482
Low-dose IL-2 is a promising immunotherapy in clinical trials for treating type 1 diabetes. A new IL-2 analog, IL-2/CD25 fusion protein, has been shown to more efficiently delay or prevent diabetes in NOD mice by expanding the population of activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16967a72285fc29f4e2994c235ff71bd
https://doi.org/10.2337/figshare.22280644
https://doi.org/10.2337/figshare.22280644
Publikováno v:
Cell Reports. 41:111792
Glucagon secretion from pancreatic alpha cells is crucial to prevent hypoglycemia. For reasons still unknown, people with type 1 diabetes lose this glucoregulatory mechanism and are susceptible to dangerous hypoglycemia. Here we show that alpha cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11356031e33d301e4bc0248c7067cd9f
https://doi.org/10.1016/j.celrep.2022.111792
https://doi.org/10.1016/j.celrep.2022.111792
Autor:
Julia K. Panzer, Alejandro Caicedo
Publikováno v:
Diabetes
Life-threatening hypoglycemia is a limiting factor in the management of type 1 diabetes. People with diabetes are prone to develop hypoglycemia because they lose physiological mechanisms that prevent plasma glucose levels from falling. Among these so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32db4cf8c14b05644f734f7f37f6d390
https://pubmed.ncbi.nlm.nih.gov/34872936
https://pubmed.ncbi.nlm.nih.gov/34872936
Autor:
Travis Dawson, Raveen Rathnasinghe, Alejandro Caicedo, Jingjin Qui, Mark A. Atkinson, Seunghee Kim-Schulze, Adeeb H. Rahman, Geoffrey Kelly, Teresa Aydillo, Michael Schotsaert, Verena van der Heide, Amanda L. Posgai, Daniel Geanon, Irina Kusmartseva, Darwin D'Souza, Brian Lee, Brad Rosenberg, Julia K. Panzer, Diana Handler, Sonia Jangra, Dirk Homann, Phillip Cohen, Randy Albrecht, Sadaf Aslam, Adolfo García-Sastre
Publikováno v:
SSRN Electronic Journal.
Concerns that infection with SARS-CoV-2, the etiological agent of COVID-19, may cause new-onset diabetes persist amidst an evolving research landscape, and precise risk assessment is hampered by at times conflicting evidence. Here, leveraging compreh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3d79fe80dcccfa7495a3177458fcad
https://doi.org/10.2139/ssrn.3945929
https://doi.org/10.2139/ssrn.3945929
Autor:
Alejandro Caicedo, Alejandro Tamayo, Jonathan Weitz, Joana Almaça, Mark A. Atkinson, Sirlene Cechin, Stephan Speier, Ricardo L. Pastori, Juan Domínguez-Bendala, Christopher A. Fraker, Dagmar Klein, Mirza Muhammad Fahd Qadir, Maria Beery, Julia K. Panzer, Yaisa B. Moreno-Hernández, Irina Kusmartseva, Silvia Álvarez-Cubela, Camillo Ricordi, Alberto Pugliese, Helmut Hiller
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications
Nature Communications
The culture of live pancreatic tissue slices is a powerful tool for the interrogation of physiology and pathology in an in vitro setting that retains near-intact cytoarchitecture. However, current culture conditions for human pancreatic slices (HPSs)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e123e72828be85ecd651c6ff699924e5
https://doi.org/10.1038/s41467-020-17574-x
https://doi.org/10.1038/s41467-020-17574-x