Spatially organized multicellular immune hubs in human colorectal cancer

Autor: Sébastien Vigneau, Arlene H. Sharpe, William H. Ge, Toni Delorey, Karin Pelka, Katherine Xu, Angela M. Magnuson, Emma K. Hill, Marios Giannakis, Susannah T. Phillips, Anise S. Applebaum, Lauren K. Brais, Vjola Jorgji, Joshua D. Pirl, Ana C. Anderson, Asaf Rotem, Moshe Biton, David H. Berger, Shuji Ogino, Kimmie Ng, Ofir Cohen, Linda T. Nieman, Max N. Goder-Reiser, Max Klapholz, Genevieve M. Boland, Hiroko Kunitake, Andrew J. Aguirre, Aviv Regev, Tabea Moll, Isaac Wakiro, Dennie T. Frederick, Julia Waldman, Nir Hacohen, Mei-Ju Su, Julia K. Meehan, Ryan B. Corcoran, Benjamin Izar, Abhay Kanodia, David J. Lieb, Matan Hofree, Jason Reeves, Danielle Dionne, Jason Yeung, Vijay K. Kuchroo, Margaret L. Hoang, Thomas E. Clancy, Daniel R. Zollinger, Michael S. Cuoco, Siranush Sarkizova, Lan T. Nguyen, Orit Rozenblatt-Rosen, Sarah L. Denning, Jingyi Wu, Ronald Bleday, Julian Albers, Amitabh Srivastava, Natasha Asinovski, Conner Lambden, Nelya Melnitchouk, Laura DelloStritto, Sherry X. Chao, Ellen Todres, Judit Jané-Valbuena, Alborz Bejnood, Christopher A. Fuhrman, Jason L. Hornick, Jennifer Irani, Bruce E. Johnson, Jonathan H. Chen, Christopher Smillie, Tatyana Sharova, Brinda Vijaykumar

Publikováno v: Cell

Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd) tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To understand the rules governing these varied responses, we transcription

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99409d3d491150f7fc84cbaf5ba07cf6
https://doi.org/10.1016/j.cell.2021.08.003