Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Julia K Pagan"'
Autor:
Gergely Rona, Domenico Roberti, Yandong Yin, Julia K Pagan, Harrison Homer, Elizabeth Sassani, Andras Zeke, Luca Busino, Eli Rothenberg, Michele Pagano
Publikováno v:
eLife, Vol 7 (2018)
The mammalian FBXL10-RNF68-RNF2 ubiquitin ligase complex (FRRUC) mono-ubiquitylates H2A at Lys119 to repress transcription in unstressed cells. We found that the FRRUC is rapidly and transiently recruited to sites of DNA damage in a PARP1- and TIMELE
Externí odkaz:
https://doaj.org/article/3803e7bc369145b48f3da7f6f1d9bcc1
Autor:
Natalie M. Niemi, Lia R. Serrano, Laura K. Muehlbauer, Catherine E. Balnis, Lianjie Wei, Andrew J. Smith, Keri-Lyn Kozul, Merima Forny, Olivia M. Connor, Edrees H. Rashan, Evgenia Shishkova, Kathryn L. Schueler, Mark P. Keller, Alan D. Attie, Jonathan R. Friedman, Julia K. Pagan, Joshua J. Coon, David J. Pagliarini
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract PPTC7 is a resident mitochondrial phosphatase essential for maintaining proper mitochondrial content and function. Newborn mice lacking Pptc7 exhibit aberrant mitochondrial protein phosphorylation, suffer from a range of metabolic defects, a
Externí odkaz:
https://doaj.org/article/d6347c4096ff4f039a05ff1f1aaf0cd0
Autor:
Giang Thanh Nguyen‐Dien, Keri‐Lyn Kozul, Yi Cui, Brendan Townsend, Prajakta Gosavi Kulkarni, Soo Siang Ooi, Antonio Marzio, Nissa Carrodus, Steven Zuryn, Michele Pagano, Robert G Parton, Michael Lazarou, S Sean Millard, Robert W Taylor, Brett M Collins, Mathew JK Jones, Julia K Pagan
Publikováno v:
The EMBO Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac34a7adeef444318dd4afc89d71550e
https://doi.org/10.15252/embj.2022112767
https://doi.org/10.15252/embj.2022112767
Autor:
Giang Thanh Nguyen-Dien, Keri-Lyn Kozul, Yi Cui, Brendan Townsend, Prajakta Gosavi Kulkarni, Soo Siang Ooi, Antonio Marzio, Nissa Carrodus, Steven Zuryn, Michele Pagano, Robert G. Parton, Michael Lazarou, Sean Millard, Robert W. Taylor, Brett M. Collins, Mathew J.K. Jones, Julia K. Pagan
Cells selectively remove damaged or excessive mitochondria through mitophagy, a specialized form of autophagy, to maintain mitochondrial quality and quantity. Mitophagy is induced in response to diverse conditions, including hypoxia, cellular differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9041f54ab4d6fd80fd786e594dbbb8ee
https://doi.org/10.1101/2022.10.12.511867
https://doi.org/10.1101/2022.10.12.511867
Autor:
James E. Hudson, Dominic K. Richards, Callum R. Tucker, Julia K. Pagan, Uda Ho, Richard J. Mills, Holly K. Voges, Dominic C.H. Ng, Hannah L. Perks
Publikováno v:
Stem Cell Reports
Summary Centrosome reduction and redistribution of pericentriolar material (PCM) coincides with cardiomyocyte transitions to a post-mitotic and matured state. However, it is unclear whether centrosome changes are a cause or consequence of terminal di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a61a60296c1a7eb5e42b3fe5993e28
https://pubmed.ncbi.nlm.nih.gov/32946803
https://pubmed.ncbi.nlm.nih.gov/32946803
Publikováno v:
Cell Cycle. 16:556-564
FEM1A, FEM1B, and FEM1C are evolutionarily-conserved VHL-box proteins, the substrate recognition subunits of CUL2-RING E3 ubiquitin ligase complexes. Here, we report that FEM1 proteins are ancient regulators of Stem-Loop Binding Protein (SLBP), a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0721f1529c58e6c3b5a6eb9a673ee09c
https://doi.org/10.1080/15384101.2017.1284715
https://doi.org/10.1080/15384101.2017.1284715
Autor:
Elizabeth Sassani, Gergely Róna, Luca Busino, Harrison Homer, Eli Rothenberg, Julia K. Pagan, Domenico Roberti, Michele Pagano, Yandong Yin, András Zeke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f63e44e10135ac9f961d5e1d15cb93a4
https://doi.org/10.7554/elife.38771.026
https://doi.org/10.7554/elife.38771.026
Autor:
Elizabeth Sassani, Julia K. Pagan, Domenico Roberti, Michele Pagano, Gergely Róna, Eli Rothenberg, András Zeke, Harrison Homer, Luca Busino, Yandong Yin
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
The mammalian FBXL10-RNF68-RNF2 ubiquitin ligase complex (FRRUC) mono-ubiquitylates H2A at Lys119 to repress transcription in unstressed cells. We found that the FRRUC is rapidly and transiently recruited to sites of DNA damage in a PARP1- and TIMELE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9032f8deeca057a40cbcc9f61cda9791
https://hdl.handle.net/11591/488555
https://hdl.handle.net/11591/488555
Autor:
Laurence Florens, Anita Saraf, Prasad V. Jallepalli, Michael P. Washburn, Antonio Marzio, Michele Pagano, Julia K. Pagan, Mathew J. K. Jones
Publikováno v:
Nature Cell Biology. 17:31-43
An intercentrosomal linker keeps a cell's two centrosomes joined together until it is dissolved at the onset of mitosis. A second connection keeps daughter centrioles engaged to their mothers until they lose their orthogonal arrangement at the end of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ef5de3cabfa14e8e9edf0a3fbd5f46
https://doi.org/10.1038/ncb3076
https://doi.org/10.1038/ncb3076
Publikováno v:
Nature Reviews Drug Discovery. 13:889-903
The clinical successes of proteasome inhibitors for the treatment of cancer have highlighted the therapeutic potential of targeting this protein degradation system. However, proteasome inhibitors prevent the degradation of numerous proteins, which ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd714c0d0eaf53723cdc169a6b77d7a0
https://doi.org/10.1038/nrd4432
https://doi.org/10.1038/nrd4432