TWEAK/Fn14 Signalling Regulates the Tissue Microenvironment in Chronic Pancreatitis

Autor: N. Dianah B. Abu Bakar, Rodrigo Carlessi, Jully Gogoi-Tiwari, Julia Köhn-Gaone, Vincent Williams, Marco Falasca, John K. Olynyk, Grant A. Ramm, Janina E. E. Tirnitz-Parker

Publikováno v: Cancers; Volume 15; Issue 6; Pages: 1807

Chronic pancreatitis increases the risk of developing pancreatic cancer through the upregulation of pathways favouring proliferation, fibrosis, and sustained inflammation. We established in previous studies that the ligand tumour necrosis factor (TNF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96bb60756a8351f52441ce89123d58b5

Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential

Autor: Rodrigo Carlessi, Elena Denisenko, Ebru Boslem, Julia Köhn-Gaone, Nathan Main, N. Dianah B. Abu Bakar, Gayatri D. Shirolkar, Matthew Jones, Aaron B. Beasley, Daniel Poppe, Benjamin J. Dwyer, Connie Jackaman, M. Christian Tjiam, Ryan Lister, Michael Karin, Jonathan A. Fallowfield, Timothy J. Kendall, Stuart J. Forbes, Elin S. Gray, John K. Olynyk, George Yeoh, Alistair R.R. Forrest, Grant A. Ramm, Mark A. Febbraio, Janina E.E. Tirnitz-Parker

Publikováno v: Carlessi, R, Denisenko, E, Boslem, E, Köhn-Gaone, J, Main, N, Abu bakar, N D B, Shirolkar, G D, Jones, M, Beasley, A B, Poppe, D, Dwyer, B J, Jackaman, C, Tjiam, M C, Lister, R, Karin, M, Fallowfield, J A, Kendall, T J, Forbes, S J, Gray, E S, Olynyk, J K, Yeoh, G, Forrest, A R R, Ramm, G A, Febbraio, M A & Tirnitz-Parker, J E E 2023, ' Single-nucleus RNA sequencing of pre-malignant liver reveals disease-associated hepatocyte state with HCC prognostic potential ', Cell Genomics, pp. 100301 . https://doi.org/10.1016/j.xgen.2023.100301

Current approaches to stage chronic liver diseases have limited utility to predict liver cancer risk. Here, we employed single nucleus RNA sequencing (snRNA-seq) to characterize the cellular microenvironment of healthy and pre-malignant livers using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79b1e0fbed62d67780b4f1bbfca2265
https://doi.org/10.1016/j.xgen.2023.100301

Divergent Inflammatory, Fibrogenic, and Liver Progenitor Cell Dynamics in Two Common Mouse Models of Chronic Liver Injury

Autor: Gregory Miller, Candice Alexandra Grzelak, John K. Olynyk, Julia Köhn-Gaone, Geoffrey W. McCaughan, Grant A. Ramm, Nicholas A. Shackel, Caryn L. Elsegood, Benjamin J. Dwyer, Janina E.E. Tirnitz-Parker

Publikováno v: The American Journal of Pathology. 186:1762-1774

Complications of end-stage chronic liver disease signify a major cause of mortality worldwide. Irrespective of the underlying cause, most chronic liver diseases are characterized by hepatocellular necrosis, inflammation, fibrosis, and proliferation o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3f412dfa0a6dee3ac8bd61ccfe02cb
https://doi.org/10.1016/j.ajpath.2016.03.005

The role of liver progenitor cells during liver regeneration, fibrogenesis, and carcinogenesis

Autor: Grant A. Ramm, John K. Olynyk, Julia Köhn-Gaone, Jully Gogoi-Tiwari, Janina E.E. Tirnitz-Parker

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 310:G143-G154

The growing worldwide challenge of cirrhosis and hepatocellular carcinoma due to increasing prevalence of excessive alcohol consumption, viral hepatitis, obesity, and the metabolic syndrome has sparked interest in stem cell-like liver progenitor cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::042025f8cad3b9bc3004a4081c4220ea
https://doi.org/10.1152/ajpgi.00215.2015