Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Julia Janzen"'
Autor:
Graham Duddy, Katherine Courtis, Juliette Horwood, Jessica Olsen, Helen Horsler, Tina Hodgson, Sunita Varsani-Brown, Abdullah Abdullah, Laura Denti, Hollie Lane, Fabio Delaqua, Julia Janzen, Molly Strom, Ian Rosewell, Katharine Crawley, Benjamin Davies
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background The ability of recombinant adeno-associated virus to transduce preimplantation mouse embryos has led to the use of this delivery method for the production of genetically altered knock-in mice via CRISPR-Cas9. The potential exists
Externí odkaz:
https://doaj.org/article/95b5ec7dd7854bb08b37eb55094b38d8
Autor:
Joan Manils, Louise V Webb, Ashleigh Howes, Julia Janzen, Stefan Boeing, Anne M Bowcock, Steven C Ley
Publikováno v:
eLife, Vol 9 (2020)
To investigate how the CARD14E138A psoriasis-associated mutation induces skin inflammation, a knock-in mouse strain was generated that allows tamoxifen-induced expression of the homologous Card14E138A mutation from the endogenous mouse Card14 locus.
Externí odkaz:
https://doaj.org/article/5715b3c4645845bc95c4bf269c9d74b7
Autor:
Helen R. Flynn, Tiaan Heunis, Steven C. Ley, Teresa L. M. Thurston, Probir Chakravarty, Felix Breyer, Matthias Trost, Julia Janzen, Anetta Härtlova, Ambrosius P. Snijders, Julien Peltier
Publikováno v:
The EMBO Journal
Tumour progression locus 2 (TPL‐2) kinase mediates Toll‐like receptor (TLR) activation of ERK1/2 and p38α MAP kinases in myeloid cells to modulate expression of key cytokines in innate immunity. This study identified a novel MAP kinase‐indepen
Autor:
Julia Janzen, David M. Tarlinton, Steven C. Ley, Alexander Visekruna, Emilie Jacque, Rachel Zillwood, Stamatia Papoutsopoulou, Victor L. J. Tybulewicz, Edina Schweighoffer
Publikováno v:
The Journal of Experimental Medicine
Jacque et al. investigate the functions of NF-κB1 p105 and its associated NF-κB–binding partners in B cells, using a mutant mouse strain that carries a form of the NF-κB1 precursor that is resistant to IKK-induced proteolysis. They identify a cr
Autor:
Julia Janzen, Elke Mühlberger, Steven C. Ley, Nicholas A. Morrice, Steven Howell, Thorsten Gantke, Sabrina Boussouf
Publikováno v:
Biochemical Journal
Activation of PKR (double-stranded-RNA-dependent protein kinase) by DNA plasmids decreases translation, and limits the amount of recombinant protein produced by transiently transfected HEK (human embryonic kidney)-293 cells. Co-expression with Ebola
Autor:
Agnes Mambole-Dema, Huei Ting Yang, Steven C. Ley, Derek W. Abbott, Julia Janzen, Abduelhakem Ben-Addi, Nick Morrice, Thorsten Gantke, Karine Roget
Publikováno v:
Molecular and Cellular Biology. 32:4684-4690
Tumor progression locus 2 (TPL-2) functions as a MEK-1/2 kinase, which is essential for Toll-like receptor 4 (TLR4) activation of extracellular signal-regulated kinase 1 and 2 (ERK-1/2) mitogen-activated protein (MAP) kinases in lipopolysaccharide (L
Autor:
Steven C. Ley, Stamatia Papoutsopoulou, Christine Brender, Thorsten Gantke, Matt Handley, Monica P Belich, Huei-Ting Yang, Julia Janzen
Publikováno v:
Molecular and Cellular Biology. 32:3438-3451
The role of IκB kinase (IKK)-induced proteolysis of NF-κB1 p105 in innate immune signaling was investigated using macrophages from Nfkb1(SSAA/SSAA) mice, in which the IKK target serines on p105 are mutated to alanines. We found that the IKK/p105 si
Publikováno v:
Journal of Cell Science. 120:4345-4354
The genome of the social amoeba Dictyostelium discoideum encodes approximately 285 kinases, which represents approximately 2.6% of the total genome and suggests a signaling complexity similar to that of yeasts and humans. The behavior of D. discoideu
Autor:
Sven Kjaer, Stephen J. Smerdon, Stephen R. Martin, Christine Brender, Steven C. Ley, Abduelhakem Ben-Addi, Agnes Mambole-Dema, Julia Janzen
The MEK-1/2 kinase TPL-2 is critical for Toll-like receptor activation of the ERK-1/2 MAP kinase pathway during inflammatory responses, but it can transform cells following C-terminal truncation. IκB kinase (IKK) complex phosphorylation of the TPL-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c663a153c30647d4fb147fd55dac65f1
https://europepmc.org/articles/PMC4060680/
https://europepmc.org/articles/PMC4060680/