Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Julia J. Mack"'
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
The luminal surface of the endothelium is exposed to dynamic blood flow patterns that are known to affect endothelial cell phenotype. While many studies have documented the phenotypic changes by gene or protein expression, less is known about the rol
Externí odkaz:
https://doaj.org/article/2dbea7e9f32843fc8f11cc425472b336
Publikováno v:
Frontiers in Transplantation, Vol 2 (2023)
Transplant vasculopathy (TV) causes thickening of donor blood vessels in transplanted organs, and is a significant cause of graft loss and mortality in allograft recipients. It is known that patients with repeated acute rejection and/or donor specifi
Externí odkaz:
https://doaj.org/article/28de976b65d547b5965b7193ffd31708
Autor:
David Meriwether, Anthony E. Jones, Julianne W. Ashby, R. Sergio Solorzano-Vargas, Nasrin Dorreh, Shoreh Noori, Victor Grijalva, Andréa B. Ball, Margarita Semis, Ajit S. Divakaruni, Julia J. Mack, Harvey R. Herschman, Martin G. Martin, Alan M. Fogelman, Srinivasa T. Reddy
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 4, Pp 1095-1120 (2022)
Background and Aims: Phagocytosis (efferocytosis) of apoptotic neutrophils by macrophages anchors the resolution of intestinal inflammation. Efferocytosis prevents secondary necrosis and inhibits further inflammation, and also reprograms macrophages
Externí odkaz:
https://doaj.org/article/52510bf36cc149d699993023773c9825
Autor:
Kyung In Baek, Shyr-Shea Chang, Chih-Chiang Chang, Mehrdad Roustaei, Yichen Ding, Yixuan Wang, Justin Chen, Ryan O'Donnell, Hong Chen, Julianne W. Ashby, Xiaolei Xu, Julia J. Mack, Susana Cavallero, Marcus Roper, Tzung K. Hsiai
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Mechano-responsive signaling pathways enable blood vessels within a connected network to structurally adapt to partition of blood flow between organ systems. Wall shear stress (WSS) modulates endothelial cell proliferation and arteriovenous specifica
Externí odkaz:
https://doaj.org/article/3c6f96f1d12b475ea3bfcd2c6cb8d89c
Autor:
Pallavi Mukherjee, Arnab Chattopadhyay, Victor Grijalva, Nasrin Dorreh, Venu Lagishetty, Jonathan P. Jacobs, Bethan L. Clifford, Thomas Vallim, Julia J. Mack, Mohamad Navab, Srinivasa T. Reddy, Alan M. Fogelman
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 1, Pp 100153- (2022)
We previously reported that adding a concentrate of transgenic tomatoes expressing the apoA-I mimetic peptide 6F (Tg6F) to a Western diet (WD) ameliorated systemic inflammation. To determine the mechanism(s) responsible for these observations, Ldlr
Externí odkaz:
https://doaj.org/article/7a86a566f742407985d7ce4cb8a19be0
Autor:
Julia J. Mack, Thiago S. Mosqueiro, Brian J. Archer, William M. Jones, Hannah Sunshine, Guido C. Faas, Anais Briot, Raquel L. Aragón, Trent Su, Milagros C. Romay, Austin I. McDonald, Cheng-Hsiang Kuo, Carlos O. Lizama, Timothy F. Lane, Ann C. Zovein, Yun Fang, Elizabeth J. Tarling, Thomas Q. de Aguiar Vallim, Mohamad Navab, Alan M. Fogelman, Louis S. Bouchard, M. Luisa Iruela-Arispe
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
The arterial wall is subjected to mechanical forces that modulate endothelial cell responses. Here, Mack and colleagues identify a novel role for Notch1 as a mechanosensor in adult arteries, where it ensures junctional integrity through modulation of
Externí odkaz:
https://doaj.org/article/4f0c26b8468d4646bb1e62081f693165
Polarized Mechanosensitive Signaling Domains Protect Arterial Endothelial Cells Against Inflammation
Autor:
Soon-Gook Hong, Julianne W. Ashby, John P. Kennelly, Meigan Wu, Eesha Chattopadhyay, Rob Foreman, Peter Tontonoz, Patric Turowski, Marcus Gallagher-Jones, Julia J. Mack
Publikováno v:
bioRxiv
Endothelial cells (ECs) in the descending aorta are exposed to high laminar shear stress, which supports an anti-inflammatory phenotype that protects them from atherosclerosis. High laminar shear stress also supports flow-aligned cell elongation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24e7c71420a9a04a08b6fd9077b185d
https://europepmc.org/articles/PMC10246006/
https://europepmc.org/articles/PMC10246006/
Autor:
Susana Cavallero, Mehrdad Roustaei, Sandro Satta, Jae Min Cho, Henry Phan, Kyung In Baek, Ana M. Blázquez-Medela, Sheila Gonzalez-Ramos, Khoa Vu, Seul-Ki Park, Tomohiro Yokota, Jennifer A. Sumner, Julia J. Mack, Curt D. Sigmund, Srinivasa T. Reddy, Rongsong Li, Tzung K. Hsiai
Publikováno v:
bioRxiv
Exercise modulates vascular plasticity in multiple organ systems; however, the metabolomic transducers underlying exercise and vascular protection in the disturbed flow-prone vasculature remain under-investigated. We simulated exercise-augmented puls
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c232877c53e31e1e095074c3adc4d85f
https://doi.org/10.1101/2023.05.02.539172
https://doi.org/10.1101/2023.05.02.539172
Autor:
Julianne W. Ashby, Julia J. Mack
Publikováno v:
The American Journal of Pathology. 191:1906-1916
Since constant perfusion of blood throughout the brain is critical for neuronal health, the regulation of cerebral blood flow is complex and highly controlled. This regulation is controlled, in part, by the cerebral endothelium. In this review, multi
BackgroundNFκB drives acute vascular inflammation by activating gene expression programs in endothelial cells to promote leukocyte recruitment. Numerous negative feedback regulators of NFκB activation have been defined that promote resolution of in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b03e0f72d3ae804739b2c55ca2395cb
https://doi.org/10.1101/2022.11.03.514942
https://doi.org/10.1101/2022.11.03.514942