Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Julia Hatto"'
Autor:
Giles Pergl-Wilson, Anna King, Julia Hatto, Henry Danahay, David Andrew Sandham, Mariana Oana Popa, Emily Stanley, Parmjit Bahra, Urs Baettig, Rebecca Butler, Brian Cox, Lightfoot Megan, Christopher J. Page, Alice Young, Paul J. Groot-Kormelink, Trixie Wagner, Swarupa Kulkarni, Glyn Hughes, Edward Charles Hall, David J. Rowlands, Lee Edwards, Atwood K. Cheung, Matthew Spendiff, Tom Sharp, Kamlesh Bala, Stephen Paul Collingwood, Hazel Watson, Julia Koehler, Oliver Ross Steward, Anne-Lise Glotin, Penny Wright, Cara E. Brocklehurst, Ulrike Glaenzel, Ian Nicholls, Richard I. Robinson, Roger J. Taylor, Catherine Howsham, Brian Everatt, Darren Le Grand, Hedaythul Choudhury, Gareth Williams, Emma Budd, Martin Gosling, Pamela Tranter
Publikováno v:
Journal of Medicinal Chemistry. 64:7241-7260
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) ion channel are established as the primary causative factor in the devastating lung disease cystic fibrosis (CF). More recently, cigarette smoke exposure has been shown to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795fc619db3aa5e70b7fe14aeddd53fe
https://doi.org/10.1021/acs.jmedchem.1c00343
https://doi.org/10.1021/acs.jmedchem.1c00343
Autor:
Nicola Arnold, Julie Christie, Sandra Haberthuer, Roger J. Taylor, Alastair Denholm, Mark Keenan, Julia Hatto, Mark Mercer, Lyndon Nigel Brown, Clive Mccarthy, Neil John Press, Helen Oakman, Andrew R. Tuffnell, Morris Tweed, Alexandre Trifilieff, Robert Cheung, Joseph D. Fullerton, Thomas H. Keller, David Beer, Helene Sahri, Pamela Tranter
Publikováno v:
Journal of Medicinal Chemistry. 58:6747-6752
Herein we describe the optimization of a series of PDE4 inhibitors, with special focus on solubility and pharamcokinetics, to clinical compound 2, 4-(8-(3-fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic acid. Although compound 2 produc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1713cba513710940b786b9defedf19
https://doi.org/10.1021/acs.jmedchem.5b00902
https://doi.org/10.1021/acs.jmedchem.5b00902
Autor:
Julia Hatto, Oliver Ross Steward, Simon J. Watson, Anne-Marie D’Souza, Urs Baettig, Thomas Kuhnle, Richard I. Robinson, Eva Neumann, Benjamin Martin, Neil John Press, David Porter, Xinzhong Lai
Publikováno v:
Organic Process Research & Development. 19:1038-1043
The synthesis of a CXCR2 antagonist is presented, highlighting the process changes made from research synthesis to clinical supply. The target compound is the choline salt of a nonsymmetrical squaramide, and the modifications to the synthetic route w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5a09aa635bcb0da90bd0be63cf97f38
https://doi.org/10.1021/acs.oprd.5b00072
https://doi.org/10.1021/acs.oprd.5b00072
Autor:
Catherine Ritchie, Lucy Barker, Matthew Bm Thomas, Jodie Manini, Elisabeth Willard, Jennifer Willis, Zarin Brown, Edward Charles Hall, Gareth Williams, Ryan West, Steven J. Charlton, David Andrew Sandham, Lyndon Nigel Brown, Simon J. Watson, Janet Maas, Devnandan Chatterjee, David A. Sykes, Nicholas Duggan, Katharine L. Turner, Gerald Dubois, David C. Budd, Bindi Sohal, Rowan Stringer, Rachael Profit, Darren Riddy, Duncan Shaw, Julia Hatto, Brian Cox
Further optimization of an initial DP2 receptor antagonist clinical candidate NVP-QAV680 led to the discovery of a follow-up molecule 2-(2-methyl-1-(4-(methylsulfonyl)-2-(trifluoromethyl)benzyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)acetic acid (compound 11,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e65a3f67567222f76078480d2373e99e
https://europepmc.org/articles/PMC5430394/
https://europepmc.org/articles/PMC5430394/
Autor:
John R. Fozard, Martin Gosling, David Farr, Lynne Jordan, David A. Sykes, Darryl Brynley Jones, David Beattie, Joe Fullerton, Lyndon Nigel Brown, Julia Hatto, Rachel Profit, Mark Mercer, Diana Janus, Christine Lewis, Helen Oakman, Robin Alec Fairhurst, Friedrich Schuerch, Michelle Bradley, Nicola Arnold, Roger J. Taylor, Janet Maas, Steven J. Charlton, Andrew Brearley, Andrew R. Tuffnell, Alexandre Trifilieff, Clive Mccarthy, Neil John Press
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4341-4347
The optimisation of two series of 4-hydroxybenzothiazolone derived β2-adrenoceptor agonists, bearing α-substituted cyclopentyl and β-phenethyl amino-substituents, as inhaled long-acting bronchodilators is described. Analogues were selected for syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6783b59db6f184a0eb19d182e169bc4
https://doi.org/10.1016/j.bmcl.2014.06.014
https://doi.org/10.1016/j.bmcl.2014.06.014
Autor:
Robin Alec Fairhurst, Joseph D. Fullerton, David Andrew Sandham, Heinz E. Moser, Mauro Zurini, Sandra Haberthuer, Darryl Brynley Jones, Mark Dodds, Julia Hatto, Gurdip Bhalay, Colin Howes, Paul Nicklin, Simon J. Watson, David Farr, Reto Naef, Irene Muller, Andrew Dunstan, Nichola J. Arnold, Nicholas James Devereux, Morris Tweed, Angela Glen, Katharine L. Turner, Beate Leuenberger, David Beer, Sylvie Gomez, Ruth Arnold, Thomas H. Keller, Stephen Paul Collingwood, Sarah Craig
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:2376-2379
Inhibitors of PDE5 are useful therapeutic agents for treatment of erectile dysfunction. A series of novel xanthine derivatives has been identified as potent inhibitors of PDE5, with good levels of selectivity against other PDE isoforms, including PDE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e21375e8e7ea71d3deb6323b8cc3fb4
https://doi.org/10.1016/j.bmcl.2006.11.019
https://doi.org/10.1016/j.bmcl.2006.11.019
Autor:
Helene Sahri, Julie Christie, Neil John Press, Mark Keenan, Sandra Haberthuer, Morris Tweed, Andrew R. Tuffnell, Mark Mercer, Joseph D. Fullerton, John R. Fozard, Thomas H. Keller, Nicola Elaine Press, Lyndon Nigel Brown, Roger J. Taylor, Clive Mccarthy, Julia Hatto, Robert Cheung, Pamela Tranter
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3081-3085
The synthesis and SAR of 5-heterocycle-substituted aminothiazole adenosine receptor antagonists is described. Several compounds show high affinity and selectivity for the A2B and A3 receptors. One compound (5f) shows good ADME properties in the rat a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3947523839cef2983228f572e9013e7c
https://doi.org/10.1016/j.bmcl.2005.04.021
https://doi.org/10.1016/j.bmcl.2005.04.021
Autor:
Jennifer Willis, Devnandan Chatterjee, Elisabeth Willard, Gareth Williams, Zarin Brown, Duncan Shaw, Ryan West, Edward Charles Hall, David Andrew Sandham, Bindi Sohal, Julia Hatto, Steven J. Charlton, Lucy Barker, Gerald Dubois, Janet Maas, Jodie Manini, Rowan Stringer, Nicholas Duggan, Catherine Ritchie, David C. Budd, Katharine L. Turner, Brian Cox, Catherine Leblanc, Lyndon Nigel Brown, Simon J. Watson, David A. Sykes, Matthew Thomas, Darren Riddy, Rachael Profit
Publikováno v:
ACS Medicinal Chemistry Letters. 8:987-987
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::938165c3ed79370061b1dfa60d8a65e1
https://doi.org/10.1021/acsmedchemlett.7b00353
https://doi.org/10.1021/acsmedchemlett.7b00353
Publikováno v:
Tetrahedron. 51:7999-8014
Phosphate derivatives of muramic acid, incorporating a lipid-like group, have been synthesised as potential inhibitors of bacterial transglycosylase. The Lewis acid catalysed addition of unsaturated alkyl silanes to methyl α-D-glucopyranoside, follo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::703224103bd7371f095d2344dc0be1ca
https://doi.org/10.1016/0040-4020(95)00415-5
https://doi.org/10.1016/0040-4020(95)00415-5
Autor:
Sandra Haberthuer, Trixie Wagner, Lyndon Nigel Brown, Julia Hatto, Nicola Arnold, Clive Mccarthy, Julie Christie, John R. Fozard, Helene Sahri, Helen Oakman, Thomas H. Keller, Roger J. Taylor, Robert Cheung, Mark Keenan, Neil John Press, Joseph D. Fullerton, Andrew R. Tuffnell, Alexandre Trifilieff, John W. Tyler, David Beer, Alastair Denholm, Morris Tweed, Mark Mercer, Pamela Tranter
Publikováno v:
Journal of medicinal chemistry. 55(17)
The solubility-driven optimization of a series of 1,7-napthyridine phosphodiesterase-4 inhibitors is described. Directed structural changes resulted in increased aqueous solubility, enabling superior pharmacokinetic properties with retention of PDE4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817ed3d0e78a77ec4c0cc42ee5087e6b
https://pubmed.ncbi.nlm.nih.gov/22889281
https://pubmed.ncbi.nlm.nih.gov/22889281