Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Julia Griffiths"'
Autor:
Leanne Grimes, Paul J. Kemp, Andrea Brancale, Mark T. Young, Wynand van der Goes van Naters, Gaia Pasqualetto, Julia Griffiths
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
The P2X receptor family of ATP-gated cation channels are attractive drug targets for pain and inflammatory disease, but no subtype-selective agonists, and few partially selective agonists have been described to date. As proof-of-concept for the disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b8add2f332c1cfba779e51cb1bbd565
http://link.springer.com/article/10.1038/s41598-020-65169-9
http://link.springer.com/article/10.1038/s41598-020-65169-9
Autor:
Konrad Beck, George Nounesis, Michail Nomikos, Ewan MacDonald, Julia Griffiths, Francis Anthony Lai, Leon G D'Cruz, Lynda Blayney, Angelos Thanassoulas
Publikováno v:
Biochimica et biophysica acta. 1830(10)
BACKGROUND: This study was designed to determine whether the cardiac ryanodine receptor (RyR2) central domain, a region associated with catecholamine polymorphic ventricular tachycardia (CPVT) mutations, interacts with the RyR2 regulators, ATP and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caaab7f51739418a35bbc97eb6f52f82
https://pubmed.ncbi.nlm.nih.gov/23747301
https://pubmed.ncbi.nlm.nih.gov/23747301
Publikováno v:
Cardiovascular research. 85(1)
Aims Our objective was to explore the functional interdependence of protein kinase A (PKA) phosphorylation with binding of modulatory FK506 binding proteins (FKBP12/12.6) to the ryanodine receptor (RyR). RyR type 1 or type 2 was prepared from rabbit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11fc706cade58f60b4a6b0c42739948f
https://pubmed.ncbi.nlm.nih.gov/19661110
https://pubmed.ncbi.nlm.nih.gov/19661110
Autor:
Michail Nomikos, Julia Griffiths, Ewan McDonald, F. Anthony Lai, Leon G D'Cruz, Konrad Beck, Lynda Blayney
Publikováno v:
Biophysical Journal. 98:511a
The cardiac ryanodine receptor (RyR2) Ca2+ release channel plays a central role in the rapid calcium release from the sarcoplasmic reticulum that is essential for muscle excitation-contraction coupling. Discrete mutations that have been discovered wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6aa59b27117ab9709d5ceb9ce39d2de
https://doi.org/10.1016/j.bpj.2009.12.2783
https://doi.org/10.1016/j.bpj.2009.12.2783
Autor:
Julia Griffiths, Colin Parish
Publikováno v:
Nursing Standard. 15:13-13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f5fa80a74ded31c4cb46d48cb83dd3a
https://doi.org/10.7748/ns.15.21.13.s34
https://doi.org/10.7748/ns.15.21.13.s34
Autor:
Michail Nomikos, Leon G D'Cruz, Lynda Blayney, Ewan McDonald, Julia Griffiths, F. Anthony Lai
Publikováno v:
Biophysical Journal. (2):442a-443a
The sarcoplasmic reticulum (SR) of cardiomyocytes contains the cardiac ryanodine receptor (RyR2) - a calcium release channel that plays a pivotal role in mediating the SR calcium release essential for cardiac excitation-contraction coupling. Discrete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8c3d7e5af64607e6292aa1338814b1d
Publikováno v:
Biophysical Journal. (3):108a
The Ryanodine Receptor (RyR) ion channel cells plays a vital part in muscle cell Excitation Contraction Coupling by regulating sarcoplasmic reticulum Ca2+ release - a process modulated by interaction with FK506 Binding Protein 12 (FKBP12). Pathologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec56cf6e9d70e9fb4f1ad1345dbc891