Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Julia Gichimu"'
Autor:
Jing Zhang, Marina A. Bellani, Jing Huang, Ryan C. James, Durga Pokharel, Julia Gichimu, Himabindu Gali, Grant Stewart, Michael M. Seidman
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Replisomes follow a schedule in which replication of DNA in euchromatin is early in S phase while sequences in heterochromatin replicate late. Impediments to DNA replication, referred to as replication stress, can stall replication forks triggering a
Externí odkaz:
https://doaj.org/article/bbbb56aa032e43b0951f58fbf4559590
Autor:
Jing Huang, Jing Zhang, Marina A. Bellani, Durga Pokharel, Julia Gichimu, Ryan C. James, Himabindu Gali, Chen Ling, Zhijiang Yan, Dongyi Xu, Junjie Chen, Amom Ruhikanta Meetei, Lei Li, Weidong Wang, Michael M. Seidman
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1794-1808.e5 (2019)
Summary: Eukaryotic replisomes are driven by the mini chromosome maintenance (MCM [M]) helicase complex, an offset ring locked around the template for leading strand synthesis by CDC45 (C) and GINS (G) proteins. Although the CDC45 MCM GINS (CMG) stru
Externí odkaz:
https://doaj.org/article/aaee9a3577bd4fb7b845c27a87340523
Autor:
Michael M Seidman, Marina A. Bellani, Himabindu Gali, Durga Pokharel, Manikandan Paramasivam, Julia Gichimu, Ryan C. James, Ishani Majumdar, Jing Huang, Jing Zhang
Publikováno v:
Journal of visualized experiments : JoVE. (173)
Considerable insight is present into the cellular response to double strand breaks (DSBs), induced by nucleases, radiation, and other DNA breakers. In part, this reflects the availability of methods for the identification of break sites, and characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7823675c812b77eb0cb8b1f894470e61
https://pubmed.ncbi.nlm.nih.gov/34398140
https://pubmed.ncbi.nlm.nih.gov/34398140
Autor:
Ryan C James, Jing Zhang, Arun K. Thazhathveetil, Marina A. Bellani, Himabindu Gali, Julia Gichimu, Althaf Shaik, Jing Huang, Michael M. Seidman, Durga Pokharel
Publikováno v:
Methods Enzymol
Replication forks encounter numerous challenges as they move through eu- and hetero-chromatin during S phase in mammalian cells. These include a variety of impediments to the unwinding of DNA by the replicative helicase such as alternate DNA structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce524e7c2eb64fac36a0846dcb05856
https://europepmc.org/articles/PMC10035509/
https://europepmc.org/articles/PMC10035509/
Autor:
Michael M. Seidman, Himabindu Gali, Jing Huang, Manikandan Paramasivam, Durga Pokharel, Julia Gichimu, Marina A. Bellani
Publikováno v:
Journal of Visualized Experiments.
The DNA Damage Response (DDR) has been extensively characterized in studies of double strand breaks (DSBs) induced by laser micro beam irradiation in live cells. The DDR to helix distorting covalent DNA modifications, including interstrand DNA crossl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98ce5bc5d4e479997b155a71a7d7626b
https://doi.org/10.3791/55541
https://doi.org/10.3791/55541
Autor:
Ryan C. James, Amom Ruhikanta Meetei, Michael M. Seidman, Zhijiang Yan, Jing Zhang, Durga Pokharel, Chen Ling, Himabindu Gali, Julia Gichimu, Marina A. Bellani, Junjie Chen, Lei Li, Weidong Wang, Dongyi Xu, Jing Huang
Publikováno v:
Cell Reports, Vol 27, Iss 6, Pp 1794-1808.e5 (2019)
Summary: Eukaryotic replisomes are driven by the mini chromosome maintenance (MCM [M]) helicase complex, an offset ring locked around the template for leading strand synthesis by CDC45 (C) and GINS (G) proteins. Although the CDC45 MCM GINS (CMG) stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::872b47bc5bd1347109164f5d937f2610
https://doi.org/10.1016/j.celrep.2019.04.032
https://doi.org/10.1016/j.celrep.2019.04.032
Autor:
Himabindu Gali, Marina A. Bellani, Jing Huang, Michael M. Seidman, Julia Gichimu, Parameswary A. Muniandy, Manikandan Paramasivam
Publikováno v:
Frontiers in Genetics
Frontiers in Genetics, Vol 7 (2016)
Frontiers in Genetics, Vol 7 (2016)
DNA interstrand crosslinks (ICLs) block unwinding of the double helix, and have always been regarded as major challenges to replication and transcription. Compounds that form these lesions are very toxic and are frequently used in cancer chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31dd1bb185f403b0bdeea8bc2745118