Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Julia G. Ruland"'
Autor:
Sina B Kirchhofer, Victor Jun Yu Lim, Sebastian Ernst, Noemi Karsai, Julia G Ruland, Meritxell Canals, Peter Kolb, Moritz Bünemann
Publikováno v:
eLife, Vol 12 (2023)
The µ opioid receptor (MOR) is the key target for analgesia, but the application of opioids is accompanied by several issues. There is a wide range of opioid analgesics, differing in their chemical structure and their properties of receptor activati
Externí odkaz:
https://doaj.org/article/d5eb377bbd5c46ab8998c51de514679a
Autor:
Christopher P Bailey, Sina B Kirchhofer, Sebastian Klindert, Moritz Bünemann, Julia G. Ruland
Publikováno v:
British Journal of Pharmacology
Background and purpose Various GPCRs have been described as being modulated in a voltage-dependent manner. Opioid analgesics act via activation of μ receptors in various neurons. As neurons are exposed to large changes in membrane potential, we were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911d66f62df676150f743e93031007a9
http://europepmc.org/articles/PMC7348086
http://europepmc.org/articles/PMC7348086
The µ opioid receptor (MOR) is the key target for analgesia, but the application of opioids is accompanied by several issues. There is a wide range of opioid analgesics, differing in their chemical structure and their properties in receptor activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00388f51000eedec4c6bfc74220f44db
https://doi.org/10.1101/2021.12.02.470941
https://doi.org/10.1101/2021.12.02.470941
Autor:
Meritxell Canals, Martin Göldner, Moritz Bünemann, Cornelius Krasel, Julia G. Ruland, Nadja Mösslein, Elke Miess, Arsalan Yousuf, Ralph Steinborn, Yunshi Yang, Arisbel B. Gondin, MacDonald J. Christie, Stefan Schulz, Michelle L. Halls
Publikováno v:
Science signaling. 11(539)
G protein receptor kinases (GRKs) and β-arrestins are key regulators of μ-opioid receptor (MOR) signaling and trafficking. We have previously shown that high-efficacy opioids such as DAMGO stimulate a GRK2/3-mediated multisite phosphorylation of co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354250343a5de84e0ded2e3cbc727a23
https://pubmed.ncbi.nlm.nih.gov/30018083
https://pubmed.ncbi.nlm.nih.gov/30018083