Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Julia G. Beveridge"'
Autor:
Helena Barker, Amanda De Paoli, Erin Tay, Given Lee, Sandra Duffy, Susan A. Charman, Robert T. Jacobs, Jitendra R. Harjani, Longjin Zhong, Marina Chavchich, Wen Wang, Da Hua Shi, Mitch Mathiew, Stephen Brand, Vicky M. Avery, Michael D. Edstein, Jonathan B. Baell, Darren J. Creek, Daniel L. Priebbenow, David M. Shackleford, Julia G. Beveridge, Karen L. White, Elly Crighton
Publikováno v:
Journal of medicinal chemistry. 64(7)
Novel 3,3'-disubstituted-5,5'-bi(1,2,4-triazine) compounds with potent in vitro activity against Plasmodium falciparum parasites were recently discovered. To improve the pharmacokinetic properties of the triazine derivatives, a new structure-activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f1d1159435727870af2d12001515a2
https://pubmed.ncbi.nlm.nih.gov/33759519
https://pubmed.ncbi.nlm.nih.gov/33759519
Autor:
Elizabeth A. Vecchio, Lauren T. May, Jonathan B. Baell, Silvia C. Teguh, Guy Y. Krippner, Ryan Brady, Daniel L. Priebbenow, Chengxue Qin, Julia G. Beveridge, Minh Deo, Rebecca H. Ritchie, Girdhar Singh Deora, Aaron DeBono
Publikováno v:
Journal of medicinal chemistry. 62(10)
Herein we describe the development of a focused series of functionalized pyridazin-3(2 H)-one-based formyl peptide receptor (FPR) agonists that demonstrate high potency and biased agonism. The compounds described demonstrated biased activation of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa513b09b2bac30b32f32192bb26f594
https://pubmed.ncbi.nlm.nih.gov/31038950
https://pubmed.ncbi.nlm.nih.gov/31038950
Autor:
Sandra Duffy, Marina Chavchich, Grennady Wirjanata, Silvia Teguh, Susan A. Charman, Rintis Noviyanti, Jitendra R. Harjani, Leonardo Lucantoni, Lian Xue, Jutta Marfurt, Michael D. Edstein, Ric N. Price, Tamir Dingjan, Stuart A. Ralph, Julia G. Beveridge, Michael A. Walters, Katherine M. Ellis, Scott Blundell, Jonathan B. Baell, Darren J. Creek, Fei Huang, Sabine Fletcher, Sarah Diab, Vicky M. Avery, Jayme L. Dahlin, Francis C. K. Chiu, Kung Ban, Jessica M. Strasser, Matthew E. Cuellar, Da Hua Shi
Publikováno v:
Journal of Medicinal Chemistry. 62(5)
A series of 3,3′-disubstituted 5,5′-bi(1,2,4-triazine) derivatives was synthesized and screened against the erythrocytic stage of Plasmodium falciparum 3D7 line. The most potent dimer, 6k, with an IC50 (50% inhibitory concentration) of 0.008 μM,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c45e06e19c62905610fabcbb3bf9abc
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