Agomelatine, a Melatonin-Derived Drug, as a New Strategy for the Treatment of Colorectal Cancer

Autor: Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Jorge Casado, Julia Escudero-Feliu, Huda Khaldy, Javier Arnedo, Ángel Carazo, Josefa León

Publikováno v: Antioxidants, Vol 12, Iss 4, p 926 (2023)

The potential use of agomelatine as an alternative treatment for colorectal cancer is evaluated in this work. The effect of agomelatine was studied in an in vitro model using two cell lines with different p53 statuses (HCT-116, wild-type p53, and HCT

Externí odkaz: https://doaj.org/article/281bf8cffa564169810048dca7a60298

Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer

Autor: María I. Aroca-Siendones, Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Michela Verbeni, Javier Arnedo, Julia Escudero-Feliu, María García-Costela, Adelina García-Robles, Ángel Carazo, Josefa León

Publikováno v: Biomedicines, Vol 9, Iss 8, p 967 (2021)

Colorectal cancer (CRC) is one of the most common tumours in developed countries. Although its incidence and mortality rates have decreased, its prognosis has not changed, and a high percentage of patients with CRC develop relapse (metachronous metas

Externí odkaz: https://doaj.org/article/9e5d61434c8b49debfcdf859c78cd7bf

β-Conglutins’ Unique Mobile Arm Is a Key Structural Domain Involved in Molecular Nutraceutical Properties of Narrow-Leafed Lupin (Lupinus angustifolius L.)

Autor: Elena Lima-Cabello, Julia Escudero-Feliu, Andreina Peralta-Leal, Pedro Garcia-Fernandez, Kadambot H. M. Siddique, Karam B. Singh, Maria I. Núñez, Josefa León, Jose C. Jimenez-Lopez

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 8; Pages: 7676

European Research Program MARIE CURIE (FP7-PEOPLE- 2011-IOF), grant ref. PIOF-GA-2011-301550
The Spanish Ministry of Economy, Industry and Competitiveness (Ramon y Cajal Research Program)
Grant ref. RYC-2014-16536
The CSIC intramural r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a9a1a591c2f4bd5b9209cbd53ba9c2
http://hdl.handle.net/10261/308130

Narrow leafed Lupin (Lupinus angustifolius L.) β-Conglutin seed proteins as a new natural cytotoxic agents against breast cancer cells

Autor: Julia Escudero-Feliu, María García-Costela, Sara Moreno-SanJuan, Jose D. Puentes-Pardo, Sandra Ríos Arrabal, Paula González-Novoa, María Isabel Núñez, Ángel Carazo, Jose C. Jimenez-Lopez, Josefa León

Publikováno v: Nutrients
Volume 15
Issue 3
Pages: 523

Breast cancer (BC) is the most widespread tumor in women and the second type of most common cancer worldwide. Despite all the technical and medical advances in existing therapies, between 30 and 50% of patients with BC will develop metastasis, which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebf5859cad94fd8d669169514de4edd
http://hdl.handle.net/10261/309004

Endothelin-1 as a Mediator of Heme Oxygenase-1-Induced Stemness in Colorectal Cancer: Influence of p53

Autor: Sandra Ríos-Arrabal, Ángel Carazo, Julia Escudero-Feliu, Michela Verbeni, Josefa León, Sara Moreno-SanJuan, Alicia Martín-Lagos Maldonado, Jorge Casado, Ágata Szuba, Carlos Cano, Jose D. Puentes-Pardo, Cristina González-Puga, María García-Costela

Publikováno v: Digibug. Repositorio Institucional de la Universidad de Granada
instname
Journal of Personalized Medicine, Vol 11, Iss 509, p 509 (2021)
Journal of Personalized Medicine
Volume 11
Issue 6
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)

Heme oxygenase-1 (HO-1) is an antioxidant protein implicated in tumor progression, metastasis, and resistance to therapy. Elevated HO-1 expression is associated with stemness in several types of cancer, although this aspect has not yet been studied i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3cc87282144686498aa3ffa1fe47cf4
http://hdl.handle.net/10481/69009