Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Julia E. Hölper"'
Autor:
Katrin Pannhorst, Jolene Carlson, Julia E. Hölper, Finn Grey, John Kenneth Baillie, Dirk Höper, Elisabeth Wöhnke, Kati Franzke, Axel Karger, Walter Fuchs, Thomas C. Mettenleiter
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract African swine fever virus (ASFV) is a lethal animal pathogen that enters its host cells through endocytosis. So far, host factors specifically required for ASFV replication have been barely identified. In this study a genome-wide CRISPR/Cas9
Externí odkaz:
https://doaj.org/article/36473a885c47414894172d4455f00dc6
Autor:
Lisa Wendt, Matthew J. Pickin, Bianca S. Bodmer, Sven Reiche, Lucie Fénéant, Julia E. Hölper, Walter Fuchs, Allison Groseth, Thomas Hoenen
Publikováno v:
Emerging Microbes and Infections, Vol 12, Iss 2 (2023)
N6-methyladenosine (m6A) is one of the most abundant modifications of cellular RNA, where it serves various functions. m6A methylation of many viral RNA species has also been described; however, little is known about the m6A epitranscriptome of haemo
Externí odkaz:
https://doaj.org/article/62c5266ddb584950a551e67cafce10d7
Autor:
Julia E. Hölper, Finn Grey, John Kenneth Baillie, Tim Regan, Nicholas J. Parkinson, Dirk Höper, Thiprampai Thamamongood, Martin Schwemmle, Katrin Pannhorst, Lisa Wendt, Thomas C. Mettenleiter, Barbara G. Klupp
Publikováno v:
Viruses, Vol 13, Iss 8, p 1574 (2021)
Herpesviruses are large DNA viruses, which encode up to 300 different proteins including enzymes enabling efficient replication. Nevertheless, they depend on a multitude of host cell proteins for successful propagation. To uncover cellular host facto
Externí odkaz:
https://doaj.org/article/a3f7112d71f844f6b3eef668d19d5721
Autor:
Anna D. Dorsch, Julia E. Hölper, Kati Franzke, Luca M. Zaeck, Thomas C. Mettenleiter, Barbara G. Klupp
Publikováno v:
Viruses, Vol 13, Iss 6, p 1117 (2021)
The molecular mechanism affecting translocation of newly synthesized herpesvirus nucleocapsids from the nucleus into the cytoplasm is still not fully understood. The viral nuclear egress complex (NEC) mediates budding at and scission from the inner n
Externí odkaz:
https://doaj.org/article/1a502f7b4495458fbe723b41c5da4585
Publikováno v:
Cells, Vol 9, Iss 3, p 738 (2020)
Newly assembled herpesvirus nucleocapsids traverse the intact nuclear envelope by a vesicle-mediated nucleo-cytoplasmic transport for final virion maturation in the cytoplasm. For this, they bud at the inner nuclear membrane resulting in primary enve
Externí odkaz:
https://doaj.org/article/f634f043492841e2a8a12b5b1b350c27
Autor:
Alexander Schäfer, Jens Peter Teifke, Julia E. Hölper, Thomas C. Mettenleiter, Barbara G. Klupp, Julia Sehl-Ewert, Ulrike Blohm, Theresa Schwaiger
Publikováno v:
Brain pathology (Zurich, Switzerland). 32(3)
Herpes simplex encephalitis (HSE) is one of the most serious diseases of the nervous system in humans. However, its pathogenesis is still only poorly understood. Although several mouse models of predominantly herpes simplex virus 1 (HSV-1) infections
Autor:
Finn Grey, Lisa Wendt, Martin Schwemmle, Katrin Pannhorst, Thomas C. Mettenleiter, Thiprampai Thamamongood, Julia E. Hölper, J K Baillie, Nicholas J. Parkinson, Dirk Höper, Barbara G. Klupp, Tim Regan
Publikováno v:
Viruses
Hölpe, J E R, Grey, F, Baillie, J K, Regan, T, Parkinson, N, Hoper, D, Thamamongood, T, Schwemmle, M, Pannhorst, K, Wendt, L, Mettenleiter, T C & Klupp, B G 2021, ' A genome-wide CRISPR/Cas9 screen reveals the requirement of host sphingomyelin synthase 1 for infection with Pseudorabies virus mutant gD–Pass ', Viruses, vol. 13, no. 8, 1574 . https://doi.org/10.3390/v13081574
Volume 13
Issue 8
Viruses, Vol 13, Iss 1574, p 1574 (2021)
Hölpe, J E R, Grey, F, Baillie, J K, Regan, T, Parkinson, N, Hoper, D, Thamamongood, T, Schwemmle, M, Pannhorst, K, Wendt, L, Mettenleiter, T C & Klupp, B G 2021, ' A genome-wide CRISPR/Cas9 screen reveals the requirement of host sphingomyelin synthase 1 for infection with Pseudorabies virus mutant gD–Pass ', Viruses, vol. 13, no. 8, 1574 . https://doi.org/10.3390/v13081574
Volume 13
Issue 8
Viruses, Vol 13, Iss 1574, p 1574 (2021)
Herpesviruses are large DNA viruses, which encode up to 300 different proteins including enzymes enabling efficient replication. Nevertheless, they depend on a multitude of host cell proteins for successful propagation. To uncover cellular host facto
Autor:
Barbara Kropff, Thomas C. Mettenleiter, Janna Schmitz, Vadim Makarov, Marco Thomas, Elke Bogner, Rebekka Adfeldt, Natalia Monakhova, Barbara G. Klupp, Julia E. Hölper
Publikováno v:
Antimicrob Agents Chemother
Herpesviruses are widespread and can cause serious illness. Many currently available antiviral drugs have limited effects, result in rapid development of resistance, and often exhibit dose-dependent toxicity. Especially for human cytomegalovirus (HCM
Autor:
Logan Banadyga, Michael R. Knittler, Julia Holzerland, Julia E. Hölper, Allison Groseth, Lucie Fénéant
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1008948 (2020)
PLoS Pathogens, Vol 16, Iss 10, p e1008948 (2020)
Pathogenicity often differs dramatically among even closely related arenavirus species. For instance, Junín virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), is closely related to Tacaribe virus (TCRV), which is normally avirul
Publikováno v:
J Virol
Herpesvirus nucleocapsids leave the nucleus by a vesicle-mediated translocation mediated by the viral nuclear egress complex (NEC). The NEC is composed of two conserved viral proteins, designated pUL34 and pUL31 in the alphaherpesvirus pseudorabies v