BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis.

Autor: Julia Holzerland, Lucie Fénéant, Logan Banadyga, Julia E Hölper, Michael R Knittler, Allison Groseth

Publikováno v: PLoS Pathogens, Vol 16, Iss 10, p e1008948 (2020)

Pathogenicity often differs dramatically among even closely related arenavirus species. For instance, Junín virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), is closely related to Tacaribe virus (TCRV), which is normally avirul

Externí odkaz: https://doaj.org/article/2358207138eb42849c0f99fd62dd5bb8

The non-classical major histocompatibility complex II protein SLA-DM is crucial for African swine fever virus replication

Autor: Katrin Pannhorst, Jolene Carlson, Julia E. Hölper, Finn Grey, John Kenneth Baillie, Dirk Höper, Elisabeth Wöhnke, Kati Franzke, Axel Karger, Walter Fuchs, Thomas C. Mettenleiter

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)

Abstract African swine fever virus (ASFV) is a lethal animal pathogen that enters its host cells through endocytosis. So far, host factors specifically required for ASFV replication have been barely identified. In this study a genome-wide CRISPR/Cas9

Externí odkaz: https://doaj.org/article/36473a885c47414894172d4455f00dc6

Function of Torsin AAA+ ATPases in Pseudorabies Virus Nuclear Egress

Autor: Julia E. Hölper, Barbara G. Klupp, G. W. Gant Luxton, Kati Franzke, Thomas C. Mettenleiter

Publikováno v: Cells, Vol 9, Iss 3, p 738 (2020)

Newly assembled herpesvirus nucleocapsids traverse the intact nuclear envelope by a vesicle-mediated nucleo-cytoplasmic transport for final virion maturation in the cytoplasm. For this, they bud at the inner nuclear membrane resulting in primary enve

Externí odkaz: https://doaj.org/article/f634f043492841e2a8a12b5b1b350c27

A Genome-Wide CRISPR/Cas9 Screen Reveals the Requirement of Host Sphingomyelin Synthase 1 for Infection with Pseudorabies Virus Mutant gD

Autor: Finn Grey, Lisa Wendt, Martin Schwemmle, Katrin Pannhorst, Thomas C. Mettenleiter, Thiprampai Thamamongood, Julia E. Hölper, J K Baillie, Nicholas J. Parkinson, Dirk Höper, Barbara G. Klupp, Tim Regan

Publikováno v: Viruses
Hölpe, J E R, Grey, F, Baillie, J K, Regan, T, Parkinson, N, Hoper, D, Thamamongood, T, Schwemmle, M, Pannhorst, K, Wendt, L, Mettenleiter, T C & Klupp, B G 2021, ' A genome-wide CRISPR/Cas9 screen reveals the requirement of host sphingomyelin synthase 1 for infection with Pseudorabies virus mutant gD–Pass ', Viruses, vol. 13, no. 8, 1574 . https://doi.org/10.3390/v13081574
Volume 13
Issue 8
Viruses, Vol 13, Iss 1574, p 1574 (2021)

Herpesviruses are large DNA viruses, which encode up to 300 different proteins including enzymes enabling efficient replication. Nevertheless, they depend on a multitude of host cell proteins for successful propagation. To uncover cellular host facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7b53fb9cd8449e13890fa2d2b01dda
https://pubmed.ncbi.nlm.nih.gov/34452438

BH3-only sensors Bad, Noxa and Puma are Key Regulators of Tacaribe virus-induced Apoptosis

Autor: Logan Banadyga, Michael R. Knittler, Julia Holzerland, Julia E. Hölper, Allison Groseth, Lucie Fénéant

Publikováno v: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 10, p e1008948 (2020)

Pathogenicity often differs dramatically among even closely related arenavirus species. For instance, Junín virus (JUNV), the causative agent of Argentine hemorrhagic fever (AHF), is closely related to Tacaribe virus (TCRV), which is normally avirul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3f61cac50654c855cde2fe84f3dae6
http://europepmc.org/articles/PMC7598930