Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Julia Dotterweich"'
Autor:
Andreas Evers, Simon Krah, Deniz Demir, Ramona Gaa, Desislava Elter, Christian Schroeter, Stefan Zielonka, Nicolas Rasche, Julia Dotterweich, Christine Knuehl, Achim Doerner
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTOptimal combinations of paratopes assembled into a biparatopic antibody have the capacity to mediate high-grade target cross-linking on cell membranes, leading to degradation of the target, as well as antibody and payload delivery in the case
Externí odkaz:
https://doaj.org/article/ba6e0960fee8491f977fc74b355ed448
Autor:
Julia Dotterweich, Robert J Tower, Andreas Brandl, Marc Müller, Lorenz C Hofbauer, Andreas Beilhack, Regina Ebert, Claus C Glüer, Sanjay Tiwari, Norbert Schütze, Franz Jakob
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155087 (2016)
Multiple myeloma is one of the most common hematological diseases and is characterized by an aberrant proliferation of plasma cells within the bone marrow. As a result of crosstalk between cancer cells and the bone microenvironment, bone homeostasis
Externí odkaz:
https://doaj.org/article/74eae58edc3e41648992318a5746c2ca
Autor:
Ulrich A. K. Betz, Tim Knehans, Jason Tonillo, Stefan Hecht, Dirk Mueller-Pompalla, Jan Anderl, Christian Schröter, Doreen Könning, Sabine Raab-Westphal, Nicolas Rasche, Shira Warszawski, Stefanie Kühn, Julia Dotterweich, Stephan Dickgiesser, Marcel Rieker
Publikováno v:
Bioconjugate Chemistry. 31:1070-1076
Site-specific bioconjugation technologies are frequently employed to generate homogeneous antibody-drug conjugates (ADCs) and are generally considered superior to stochastic approaches like lysine coupling. However, most of the technologies developed
Autor:
Anup Zutshi, Berend Neuteboom, Seema Kumar, Willem Sloot, Christine Knuehl, Julia Dotterweich, Jianguo Ma, Christiane Amendt, Karthik Venkatakrishnan, Taeshin Park, John Pappas, Kyoung-Ae Kim
Publikováno v:
Cancer Research. 82:5423-5423
Introduction: M1231 is a first-in-class bispecific antibody drug conjugate (ADC) targeting mucin-1 (MUC1) and epidermal growth factor receptor (EGFR), that is conjugated with a novel hemiasterlin-related microtubule inhibitor payload. Following dose,
Autor:
Christine Knuehl, Lars Toleikis, Julia Dotterweich, Jianguo Ma, Seema Kumar, Edith Ross, Claudia Wilm, Martina Schmitt, Hans Juergen Grote, Christiane Amendt
Publikováno v:
Cancer Research. 82:5284-5284
Mucin 1 (MUC1) and epidermal growth factor receptor (EGFR) are co-expressed at high prevalence in multiple cancer indications such as non-small cell lung cancer (NSCLC), esophageal squamous cell carcinoma (ESCC), head and neck squamous cell carcinoma
Autor:
Thorsten Stühmer, Martina Rudelius, Vanessa Desantis, Angelo Vacca, Zeinab Mokhtari, Anna Ruckdeschel, Paolo Trerotoli, Max Bittrich, Miriam Ritz, Andreas Rosenwald, Franz Jakob, H. Einsele, Regina Ebert, Antonio Giovanni Solimando, Julia Dotterweich, Andreas Beilhack, Carolin Graf, Andreas Brandl, Katharina Mattenheimer, Ma Frassanito
Publikováno v:
Leukemia
Cell adhesion in the multiple myeloma (MM) microenvironment has been recognized as a major mechanism of MM cell survival and the development of drug resistance. Here we addressed the hypothesis that the protein junctional adhesion molecule-A (JAM-A)
Autor:
Regina Ebert, Alexander Keller, Franz Jakob, Robert J. Tower, Doris Schneider, Katrin Schlegelmilch, S. Zeck, Norbert Schütze, Julia Dotterweich, Beate Geyer
Publikováno v:
Bone. 93
Physical interaction of skeletal precursors with multiple myeloma cells has been shown to suppress their osteogenic potential while favoring their tumor-promoting features. Although several transcriptome analyses of myeloma patient-derived mesenchyma
Publikováno v:
British Journal of Haematology. 167:272-274
Autor:
Franz Jakob, Tatjana Schilling, Julia Dotterweich, Verena Schneider, Norbert Schütze, Solange Le Blanc, Viola Zehe, Meike Simann, Melanie Krug
Publikováno v:
Bone. 78
Heparins are broadly used for the prevention and treatment of thrombosis and embolism. Yet, osteoporosis is considered to be a severe side effect in up to one third of all patients on long-term treatment. However, the mechanisms underlying this clini
Autor:
Julia, Dotterweich, Regina, Ebert, Sabrina, Kraus, Robert J, Tower, Franz, Jakob, Norbert, Schütze
Publikováno v:
Cell Communication and Signaling : CCS
CCN family member 1 (CCN1), also known as cysteine-rich angiogenic inducer 61 (CYR61), belongs to the extracellular matrix-associated CCN protein family. The diverse functions of these proteins include regulation of cell migration, adhesion, prolifer