Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

Autor: Simon F. Merz, Sebastian Korste, Lea Bornemann, Lars Michel, Pia Stock, Anthony Squire, Camille Soun, Daniel R. Engel, Julia Detzer, Holger Lörchner, Dirk M. Hermann, Markus Kamler, Joachim Klode, Ulrike B. Hendgen-Cotta, Tienush Rassaf, Matthias Gunzer, Matthias Totzeck

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Detailed characterization of cardiac damage following ischemia/reperfusion injury and detection of occurring inflammatory responses is important for the development of new therapeutic concepts. Here the authors present a method for the three-dimensio

Externí odkaz: https://doaj.org/article/3e96cf3e564a4e068419e2da632f2557

Reg proteins direct accumulation of functionally distinct macrophage subsets after myocardial infarction

Autor: Henning Warnecke, Jochen Pöling, Julia Detzer, Praveen Gajawada, Juan M. Adrian-Segarra, Holger Lörchner, Thomas Braun, Jennifer Kulhei, Hans W.M. Niessen, Stefan Günther, Yunlong Hou

Publikováno v: Lörchner, H, Hou, Y, Adrian-Segarra, J M, Kulhei, J, Detzer, J, Günther, S, Gajawada, P, Warnecke, H, Niessen, H W, Pöling, J & Braun, T 2018, ' Reg proteins direct accumulation of functionally distinct macrophage subsets after myocardial infarction ', Cardiovascular Research, vol. 114, no. 12, pp. 1667-1679 . https://doi.org/10.1093/cvr/cvy126
Cardiovascular Research, 114(12), 1667-1679. Oxford University Press

Aims Myocardial infarction (MI) causes a massive increase of macrophages in the heart, which serve various non-redundant functions for cardiac repair. The identities of signals controlling recruitment of functionally distinct cardiac macrophages to s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::048aec616927908bac9a9411c44303de
https://doi.org/10.1093/cvr/cvy126

Contemporaneous 3D characterization of acute and chronic myocardial I/R injury and response

Autor: Anthony Squire, Pia Stock, Ulrike B. Hendgen-Cotta, Dirk M. Hermann, Julia Detzer, Lea Bornemann, Joachim Klode, Tienush Rassaf, Holger Lörchner, Markus Kamler, Simon F. Merz, Camille Soun, Sebastian Korste, Matthias Totzeck, Daniel R. Engel, Lars Michel, Matthias Gunzer

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications

Cardioprotection by salvage of the infarct-affected myocardium is an unmet yet highly desired therapeutic goal. To develop new dedicated therapies, experimental myocardial ischemia/reperfusion (I/R) injury would require methods to simultaneously char

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1e3931c8b29016c1a6726ca674918b
https://www.ncbi.nlm.nih.gov/pubmed/31127113