Low frequency of flares during pregnancy and post-partum in stable lupus patients

Autor: Julia Davis-Porada, Mimi Y. Kim, Marta M. Guerra, Carl A. Laskin, Michelle Petri, Michael D. Lockshin, Lisa R. Sammaritano, D. Ware Branch, Allen Sawitzke, Joan T. Merrill, Jill P. Buyon, Jane E. Salmon

Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-8 (2020)

Abstract Background Lupus patients are at risk for pregnancy loss, and it has been generally accepted that women with SLE should have low disease activity prior to conception. However, there are conflicting results regarding the effect of pregnancy o

Externí odkaz: https://doaj.org/article/300210428d164ca5b36b01e0553d3906

SARS-CoV-2 infection and recovery in children: Distinct T cell responses in MIS-C compared to COVID-19

Autor: Ksenia Rybkina, Joseph N. Bell, Marissa C. Bradley, Teddy Wohlbold, Marika Scafuro, Wenzhao Meng, Rebecca C. Korenberg, Julia Davis-Porada, Brett R. Anderson, Rachel J. Weller, Joshua D. Milner, Anne Moscona, Matteo Porotto, Eline T. Luning Prak, Kalpana Pethe, Thomas J. Connors, Donna L. Farber

Publikováno v: Journal of Experimental Medicine. 220

SARS-CoV-2 infection for most children results in mild or minimal symptoms, though in rare cases severe disease can develop, including a multisystem inflammatory syndrome (MIS-C) with myocarditis. Here, we present longitudinal profiling of immune res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d436c599477ce48b3daf30345ab59bee
https://doi.org/10.1084/jem.20221518

Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum

Autor: Rei Matsumoto, Yun Zhu, Emily M. Mace, Michael Chait, Wen-Hsuan W. Lin, Eldad A. Hod, Didier Decimo, Branka Horvat, Matthew R. Baldwin, Steven B. Wells, Stephen A. Ferrara, Stuart P. Weisberg, Julia Davis-Porada, Pranay Dogra, Donna L. Farber, Debora Stelitano, Emma Idzikowski, Flavia Dei Zotti, Cyrille Mathieu, Francesca T. Bovier, Matteo Porotto, Zachary C. Bitan, Sandeep N. Wontakal, Francesca La Carpia, Anne Moscona, Krystalyn E. Hudson, Joshua I. Gray, Thomas J. Connors, Peter A. Szabo, Joshua D. Milner, Maya Meimei Li Poon

Publikováno v: Nature Immunology
Nature Immunology, Nature Publishing Group, 2020, pp.25-31. ⟨10.1038/s41590-020-00826-9⟩
Nature Immunology, 2020, pp.25-31. ⟨10.1038/s41590-020-00826-9⟩
Nat Immunol

International audience; Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age1,2. Adults develop respiratory symptoms, which can progress to acute respiratory distress syndrome (ARDS) in the most severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5392d06d54951e78528c4d7092f52e03
https://doi.org/10.1038/s41590-020-00826-9

TRM and mucosal tissue sites are protected from age-associated phenotypic changes in secondary lymphoid organs

Autor: Nora Lam, Daniel P Caron, Julia Davis-Porada, Isaac J Jensen, YoonSeung Lee, Rory Morrison-Colvin, Maya M.L. Poon, Peter A Szabo, Basak B Ural, Steven B Wells, Masaru Kubota, Rei Matsumoto, Donna L Farber

Publikováno v: The Journal of Immunology. 208:57.13-57.13

The persistence and maintenance of immunological memory is critical for long-term immunity generated in response to infection and vaccination. Aging of memory T cells in humans has predominantly been studied in the peripheral blood, and considerably

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08d8107d95f1c70fe88e95f3c4697693
https://doi.org/10.4049/jimmunol.208.supp.57.13

Analysis of respiratory and systemic immune responses in COVID-19 reveals mechanisms of disease pathogenesis

Autor: Matthew Steinle, Pranay Dogra, Michael Chait, Stuart P. Weisberg, Maya M.L. Poon, Jing Zhou, Rei Matsumoto, Emma Idzikowski, Peter A. Sims, Izabela Krupska, Sean Mackay, Andrew J. Yates, Matthew R. Baldwin, Anjali Saqi, Donna L. Farber, Chloé Pasin, Joshua I. Gray, Amy Ku, Sinead E. Morris, Thomas J. Connors, Peter A. Szabo, Steven B. Wells, Julia Davis-Porada

Publikováno v: medRxiv

SUMMARYImmune responses to respiratory viruses like SARS-CoV-2 originate and function in the lung, yet assessments of human immunity are often limited to blood. Here, we conducted longitudinal, high-dimensional profiling of paired airway and blood sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df4d4b05bcb761c53ef39700fb65f3cc
https://doi.org/10.1101/2020.10.15.20208041