Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Julia Claasen"'
Autor:
Lukas P. Frenzel, Johannes Bloehdorn, René P. Zahedi, Barbara Eichhorst, Julia Claasen, Clare Sun, Albert Sickmann, Laura Beckmann, Stefan Loroch, Kirsten Fischer, Valeska Berg, Adrian Wiestner, Eugen Tausch, Stephan Stilgenbauer, Chingiz Underbayev, Marc Seifert, Michael Hallek, Matteo Oliverio, Clarissa Dickhut, A.-M. Fink, Clemens M. Wendtner, Sandra Robrecht, Daniel Thomalla, Alexandra da Palma Guerreiro, Olaf Merkel, Lauren T Vaughn, Malte F. Hülsemann
Bruton tyrosine kinase (BTK) inhibitors are highly active drugs for the treatment of chronic lymphocytic leukemia (CLL). To understand the response to BTK inhibitors on a molecular level, we performed (phospho)proteomic analyses under ibrutinib treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67984f8080a1e118bdb0a6e9eb25cab6
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85109028148
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85109028148
Autor:
Lukas P. Frenzel, Jens M. Chemnitz, Julia Claasen, Christof Scheid, Alexander Shimabukuro-Vornhagen, Udo Holtick, Holger Fröhlich, Clemens M. Wendtner, Sebastian Theurich, Michael von Bergwelt-Baildon
Publikováno v:
Annals of Hematology. 94:129-137
The recovery of the host immune system after allogeneic hematopoietic stem cell transplantation is pivotal to prevent infections, relapse, and secondary malignancies. In particular, numerical CD4+ T cells reconstitution is delayed and CD4 helper cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da575053de2248b6b01edf15f2ac3d1e
https://doi.org/10.1007/s00277-014-2166-1
https://doi.org/10.1007/s00277-014-2166-1
Autor:
Valeska Feldhaus, Susanne Brodesser, Michael A. Baumann, Michaela Patz, Julia Claasen, Michael Hallek, Reinhild Brinker, Christian P. Pallasch, Clemens-Martin Wendtner, Lukas P. Frenzel, Janine Schwamb
Publikováno v:
Blood. 120:3978-3985
Survival of chronic lymphocytic leukemia (CLL) cells is triggered by several stimuli, such as the B-cell receptor (BCR), CD40 ligand (CD40L), or interleukin-4 (IL-4). We identified that these stimuli regulate apoptosis resistance by modulating sphing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab605c28f6c07eb3e9f4294449d60f35
https://doi.org/10.1182/blood-2012-05-431783
https://doi.org/10.1182/blood-2012-05-431783
Autor:
Lukas P. Frenzel, Michaela Patz, Iris Gehrke, Michael Hallek, Günter Krause, Julia Claasen, Mirjam Kuckertz, Aditya Veldurthy, Clemens-Martin Wendtner
Publikováno v:
Oncology Research and Treatment. 35:420-426
With sorafenib displaying the highest affinities for Flt3, VEGFR (vascular endothelial growth factor receptor) and Raf and dasatinib for Abl and Src kinases, the profiles of kinases targeted by these inhibitors differ strongly.Dose-dependent effects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af285063484ffec438a2d4a228c9c61
https://doi.org/10.1159/000341081
https://doi.org/10.1159/000341081
Autor:
Günter Krause, K-H Heider, Julia Claasen, C M Wendtner, Michaela Patz, Verena Vondey, P Isaeva, Lukas P. Frenzel, I. Baki, M Wigger, Michael Hallek, Mirjam Kuckertz, Susan Kerwien, Reinhild Brinker
Publikováno v:
Leukemia. 26:546-549
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913060926573fb912db6d3c95cb2aea4
https://doi.org/10.1038/leu.2011.233
https://doi.org/10.1038/leu.2011.233
Autor:
Lukas P. Frenzel, Reinhild Brinker, Christian P. Pallasch, Hamid Kashkar, Julia Claasen, Michaela Patz, Michael Hallek, Alexandra Schulz, Clemens-Martin Wendtner
Publikováno v:
British Journal of Haematology. 152:191-200
Given that aggressive DNA damaging chemotherapy shows suboptimal efficacy in chronic lymphocytic leukaemia (CLL), alternative therapeutic approaches are needed. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is able to induce tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::171065e28625155585d09c2010975859
https://doi.org/10.1111/j.1365-2141.2010.08426.x
https://doi.org/10.1111/j.1365-2141.2010.08426.x
Autor:
Christian P. Pallasch, Christoph Plass, Janine Schwamb, Lukas P. Frenzel, Nadine Plume, Julia Claasen, Carolin Konermann, Clemens M. Wendtner, Reinhild Brinker, Bernd Wollnik, Rainer Claus
Publikováno v:
International Journal of Cancer. 128:2495-2500
Inappropriate nuclear factor (NF) κB activity is one major hallmark of B-cell malignancies and chronic lymphocytic leukemia (CLL). NFκB-dependent genes are involved in antiapoptosis, cell proliferation and metastasis and are responsible for surviva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c065b91aadec6fdb464b8da81e5b9cd
https://doi.org/10.1002/ijc.25579
https://doi.org/10.1002/ijc.25579
Autor:
Christian P. Pallasch, Christine Mayr, Nadine Kutsch, Joachim L. Schultze, Yoon Jung Park, Clemens-Martin Wendtner, Andreas Rosenwald, Rainer Claus, Alexandra Schulz, Günter Krause, Christoph Plass, Michaela Patz, Daniela Eggle, Svenja Debey-Pascher, Julia Claasen, Lukas P. Frenzel, Michael Hallek, Susanne Hagist
Publikováno v:
Blood. 114:3255-3264
MicroRNAs (miRNA) play a key role in cellular regulation and, if deregulated, in the development of neoplastic disorders including chronic lymphocytic leukemia (CLL). RNAs from primary cells of 50 treatment-naive CLL patients and peripheral B cells o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96aedcab8f55e721ca05507a1e4a31c8
https://doi.org/10.1182/blood-2009-06-229898
https://doi.org/10.1182/blood-2009-06-229898
Autor:
Lukas P, Frenzel, Michaela, Patz, Christian P, Pallasch, Reinhild, Brinker, Julia, Claasen, Alexandra, Schulz, Michael, Hallek, Hamid, Kashkar, Clemens-Martin, Wendtner
Publikováno v:
British journal of haematology. 152(2)
Given that aggressive DNA damaging chemotherapy shows suboptimal efficacy in chronic lymphocytic leukaemia (CLL), alternative therapeutic approaches are needed. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is able to induce tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f16ca1c66c1e44af4d07183007b43a5
https://pubmed.ncbi.nlm.nih.gov/21091905
https://pubmed.ncbi.nlm.nih.gov/21091905
Erufosine, a novel alkylphosphocholine, induces apoptosis in CLL through a caspase-dependent pathway
Autor:
Michael Hallek, Christian P. Pallasch, Alexandra Schulz, Sonja Katharina Königs, Janine Schwamb, Clemens-Martin Wendtner, Julia Claasen, Lars H. Lindner, Aditya Veldurthy, Hansjoerg Eibl, Reinhild Brinker
Publikováno v:
Leukemia research. 34(8)
The alkylphosphocholine (APC) erufosine is a synthetic phospholipid analogue with antineoplastic activity. APC are known to interact with lipid metabolism and modulate cellular signaling pathways, particularly the phosphorylation of Akt. Here, in pri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b97eb6435ec4b2266e288d1252dbd337
https://pubmed.ncbi.nlm.nih.gov/20092894
https://pubmed.ncbi.nlm.nih.gov/20092894