Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Julia C Heiby"'
Autor:
Aleksandar Bartolome, Julia C Heiby, Domenico Di Fraia, Ivonne Heinze, Hannah Knaudt, Ellen Spaeth, Omid Omrani, Alberto Minetti, Maleen Hofmann, Joanna M Kirkpatrick, Therese Dau, Alessandro Ori
Publikováno v:
eLife, Vol 13 (2024)
Proteasomes are essential molecular machines responsible for the degradation of proteins in eukaryotic cells. Altered proteasome activity has been linked to neurodegeneration, auto-immune disorders and cancer. Despite the relevance for human disease
Externí odkaz:
https://doaj.org/article/eb11939432d947b9a7853c59ac4621e3
Autor:
Agnes Banaszek, Thomas G. P. Bumm, Boris Nowotny, Maria Geis, Kim Jacob, Matthias Wölfl, Johannes Trebing, Kirstin Kucka, Dina Kouhestani, Tea Gogishvili, Bastian Krenz, Justina Lutz, Leo Rasche, Dirk Hönemann, Hannes Neuweiler, Julia C. Heiby, Ralf C. Bargou, Harald Wajant, Hermann Einsele, Gert Riethmüller, Gernot Stuhler
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
The restriction of appropriate tumour-specific antigens is a current limitation for T cell-engaging immunotherapy. Here, the authors have designed a new system constituted by two halve antibodies, which engage T cells once binding to two different an
Externí odkaz:
https://doaj.org/article/2c0baf0c95d243a58f06fcb336d652c2
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Spider silk is of interest in material science research. Here the authors show that the tight binding of a spider silk protein domain relies on the amino acid methionine, which is abundant in the domain core where it facilitates dynamic shape adaptio
Externí odkaz:
https://doaj.org/article/cbb044ff25df467b8fda4b6d45554c9a
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Molecular details that underlie mechanical properties of spider silk are of great interest to material scientists. Here, the authors report a previously unknown three-state mechanism of folding and an expanded structure of a spider silk protein that
Externí odkaz:
https://doaj.org/article/9eb7e6b4b3184de388ce25a4749dd5b3
Autor:
Aleksandar Bartolome, Julia C. Heiby, Therese Dau, Domenico Di Fraia, Ivonne Heinze, Joanna M. Kirkpatrick, Alessandro Ori
SUMMARYProteasomes are essential molecular machines responsible for the degradation of proteins in eukaryotic cells. Altered proteasome activity has been linked to neurodegeneration, auto-immune disorders and cancer. Proteasomes have been exploited f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec49dcacbb2880545d5c4c77b8081232
https://doi.org/10.1101/2022.08.09.503299
https://doi.org/10.1101/2022.08.09.503299
Publikováno v:
Biomolecular NMR Assignments. 14:67-71
Web spiders use specialized glands to produce silk proteins, so-called spidroins, which assemble into extraordinarily tough silk fibers through tightly regulated phase and structural transitions. A crucial step in the polymerization of spidroins is t
Autor:
Ralf C. Bargou, Gert Riethmüller, Kim Jacob, Matthias Wölfl, Thomas Bumm, Gernot Stuhler, Hermann Einsele, Maria Geis, Dina Kouhestani, Julia C. Heiby, Leo Rasche, Johannes Trebing, Tea Gogishvili, Boris Nowotny, Justina Lutz, Harald Wajant, Dirk Hönemann, Bastian Krenz, Hannes Neuweiler, Kirstin Kucka, Agnes Banaszek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Nature Communications
Nature Communications
T cell-engaging immunotherapies are changing the landscape of current cancer care. However, suitable target antigens are scarce, restricting these strategies to very few tumor types. Here, we report on a T cell-engaging antibody derivative that comes
Autor:
Julia C. Heiby, Alessandro Ori
Publikováno v:
Current Opinion in Systems Biology. 30:100416
Publikováno v:
Biomolecular NMR assignmentsReferences. 14(1)
Web spiders use specialized glands to produce silk proteins, so-called spidroins, which assemble into extraordinarily tough silk fibers through tightly regulated phase and structural transitions. A crucial step in the polymerization of spidroins is t
Autor:
Bartolome, Aleksandar, Heiby, Julia C., Di Fraia, Domenico, Heinze, Ivonne, Knaudt, Hannah, Spaeth, Ellen, Omrani, Omid, Minetti, Alberto, Hofmann, Maleen, Kirkpatrick, Joanna M., Dau, Therese, Ori, Alessandro
Publikováno v:
eLife; 9/4/2024, p1-32, 32p