The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations

Autor: Sven Diederichs, Lorenz Bartsch, Julia C Berkmann, Karin Fröse, Jana Heitmann, Caroline Hoppe, Deetje Iggena, Danny Jazmati, Philipp Karschnia, Miriam Linsenmeier, Thomas Maulhardt, Lino Möhrmann, Johannes Morstein, Stella V Paffenholz, Paula Röpenack, Timo Rückert, Ludger Sandig, Maximilian Schell, Anna Steinmann, Gjendine Voss, Jacqueline Wasmuth, Maria E Weinberger, Ramona Wullenkord

Publikováno v: EMBO Molecular Medicine, Vol 8, Iss 5, Pp 442-457 (2016)

Abstract Cancer is a disease of the genome caused by oncogene activation and tumor suppressor gene inhibition. Deep sequencing studies including large consortia such as TCGA and ICGC identified numerous tumor‐specific mutations not only in protein�

Externí odkaz: https://doaj.org/article/f493a237e7b24fe5b81baf1eb7e2e60f

Local immune cell contributions to fracture healing in aged individuals – A novel role for interleukin 22

Autor: Christian H. Bucher, Julia C. Berkmann, Lisa-Marie Burkhardt, Carolin Paschke, Claudia Schlundt, Annemarie Lang, Angelique Wolter, Alexandra Damerau, Sven Geissler, Hans-Dieter Volk, Georg N. Duda, Katharina Schmidt-Bleek

Publikováno v: Experimental & Molecular Medicine. 54:1262-1276

With increasing age, the risk of bone fractures increases while regenerative capacity decreases. This variation in healing potential appears to be linked to adaptive immunity, but the underlying mechanism is still unknown. This study sheds light on i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::507d0582bd11dd64dce64192c5d297ef
https://doi.org/10.1038/s12276-022-00834-9

Early pH Changes in Musculoskeletal Tissues upon Injury—Aerobic Catabolic Pathway Activity Linked to Inter-Individual Differences in Local pH

Autor: Julia C. Berkmann, Aaron X. Herrera Martin, Agnes Ellinghaus, Claudia Schlundt, Hanna Schell, Evi Lippens, Georg N. Duda, Serafeim Tsitsilonis, Katharina Schmidt-Bleek

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 7, p 2513 (2020)

Local pH is stated to acidify after bone fracture. However, the time course and degree of acidification remain unknown. Whether the acidification pattern within a fracture hematoma is applicable to adjacent muscle hematoma or is exclusive to this reg

Externí odkaz: https://doaj.org/article/37f709b0e47b475db6def77c9d009010

Engineered pH-Responsive Mesoporous Carbon Nanoparticles for Drug Delivery

Autor: Konstantinos Spyrou, Katharina Schmidt-Bleek, Miguel Gisbert-Garzarán, Dimitra Giasafaki, Theodore Steriotis, Georg N. Duda, María Vallet-Regí, Daniel Lozano, Georgia Charalambopoulou, Julia C. Berkmann, Miguel Manzano

Publikováno v: ACS Appl Mater Interfaces
E-Prints Complutense. Archivo Institucional de la UCM
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
ACS Applied Materials & Interfaces

In this work, two types of mesoporous carbon particles with different morphology, size and pore structure have been functionalized with a self-immolative polymer sensitive to changes in pH and tested as drug nanocarriers. It is shown that their textu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efc115579c635119c7de790db6cbbe83
https://europepmc.org/articles/PMC7116326/

The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non‐coding RNA and synonymous mutations

Autor: Karin Fröse, Miriam Linsenmeier, Julia C. Berkmann, Jana Heitmann, Lino Möhrmann, Gjendine Voss, Philipp Karschnia, Sven Diederichs, Deetje Iggena, Caroline Hoppe, Lorenz Bartsch, Maria E Weinberger, Paula Röpenack, Johannes Morstein, Timo Rückert, Anna Steinmann, Stella V Paffenholz, Ludger Sandig, Ramona Wullenkord, Jacqueline Wasmuth, Danny Jazmati, Maximilian Schell, Thomas Maulhardt

Publikováno v: Diederichs, S, Bartsch, L, Berkmann, J C, Fröse, K, Heitmann, J, Hoppe, C, Iggena, D, Jazmati, D, Karschnia, P, Linsenmeier, M, Maulhardt, T, Möhrmann, L, Morstein, J, Paffenholz, S V, Röpenack, P, Rückert, T, Sandig, L, Schell, M, Steinmann, A, Voss, G, Wasmuth, J, Weinberger, M E & Wullenkord, R 2016, ' The dark matter of the cancer genome: aberrations in regulatory elements, untranslated regions, splice sites, non-coding RNA and synonymous mutations ', EMBO Molecular Medicine, vol. 8, no. 5, pp. 442-57 . https://doi.org/10.15252/emmm.201506055
EMBO Molecular Medicine

Cancer is a disease of the genome caused by oncogene activation and tumor suppressor gene inhibition. Deep sequencing studies including large consortia such as TCGA and ICGC identified numerous tumor‐specific mutations not only in protein‐coding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e689fba1ebc81913434045610d3eb18a
https://doi.org/10.15252/emmm.201506055