Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Julia C, Stingl"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Polypharmacy in older adults increases the risk of adverse drug reactions (ADRs), but studying this relationship is complex. In real-world data, the high number of medications, coupled with rare drug combinations, results in high-dimensional
Externí odkaz:
https://doaj.org/article/f415b8bfcd934a09afab2dbd305a85ab
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 161 (2024)
Background: The analysis of substrates of polymorphic cytochrome P450 (CYP) enzymes is important information to enable drug–drug interactions (DDIs) analysis and the relevance of pharmacogenetics in this context in large datasets. Our aim was to co
Externí odkaz:
https://doaj.org/article/a031389b7cb84d65b9d788a4da58d5f7
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-5 (2021)
Abstract Pharmacogenetic studies have shown involvement of cytochrome P450 enzymes in the metabolism of psychotropic drugs. However, expression and activity on endogenous substrates in the brain may underlie a constitutive role of these enzymes beyon
Externí odkaz:
https://doaj.org/article/79ce2811947f4f17879c07ac0f3e325d
Autor:
Mirco Glitscher, David Heiler Martín, Kathrin Woytinek, Benjamin Schmidt, Denna Tabari, Catharina Scholl, Julia C. Stingl, Evelyn Seelow, Mira Choi, Eberhard Hildt
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 1, Pp 159-180 (2021)
Background and aims: The Hepatitis E virus hijacks the endosomal system for its release. These structures are highly dependent on cholesterol. Hence, this study investigates the impact of HEV on cholesterol-metabolism, the effect of intracellular cho
Externí odkaz:
https://doaj.org/article/2c82aa411d1e43f98ee6cfc17d95c727
Publikováno v:
BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-20 (2020)
Abstract Background Older adults are more prone to develop adverse drug reactions (ADRs) since they exhibit numerous risk factors. The first aim was to analyse the number of spontaneous ADR reports regarding older adults (> 65) in the ADR database of
Externí odkaz:
https://doaj.org/article/dcb0daab662b426d9cede6f7397e2e1c
Autor:
Julia C. Stingl
Publikováno v:
BJPsych Open, Vol 8 (2022)
In the article Analysis of the impact of antidepressants and other medications on COVID-19 infection risk in a chronic psychiatric in-patient cohort, Catherine L. Clelland and colleagues for the first time suggest a protective effect of antidepressan
Externí odkaz:
https://doaj.org/article/aedc9a61a8fc41bc94bdd2f55dd325ec
Autor:
Immaculate M. Langmia, Katja S. Just, Sabrina Yamoune, Jürgen Brockmöller, Collen Masimirembwa, Julia C. Stingl
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Adverse drug reactions (ADRs) are one of the major causes of morbidity and mortality worldwide. It is well-known that individual genetic make-up is one of the causative factors of ADRs. Approximately 14 million single nucleotide polymorphisms (SNPs)
Externí odkaz:
https://doaj.org/article/6ea8d76ec19b495e8f188882fb9b788b
Autor:
Katja S. Just, Harald Dormann, Mathias Freitag, Marlen Schurig, Miriam Böhme, Michael Steffens, Catharina Scholl, Thomas Seufferlein, Ingo Graeff, Matthias Schwab, Julia C. Stingl
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Cytochrome P450 (CYP) 2D6 is a polymorphic enzyme expressed in the central nervous system (CNS), important in drug metabolism and with a potentially constitutive role in CNS function such as vigilance. This study aimed to analyze variability in CYP2D
Externí odkaz:
https://doaj.org/article/657a5919157248de9939a3c30aa4a8a9
Autor:
Marie-Luise Herrlein, Sascha Hein, Tobias Zahn, Ines Mhedhbi, Jan Raupach, Younes Husria, Nuka Ivalu Benz, Jonathan Eisert, Daniela Bender, Vanessa Haberger, Florian D. Hastert, Lisa Henss, Barbara S. Schnierle, Julia C. Stingl, Michael Dreher, Eberhard Hildt
Publikováno v:
Viruses, Vol 14, Iss 2, p 410 (2022)
In light of an increasing number of vaccinated and convalescent individuals, there is a major need for the development of robust methods for the quantification of neutralizing antibodies; although, a defined correlate of protection is still missing.
Externí odkaz:
https://doaj.org/article/6308a186ab2d442dac3f373702a5e91f
Autor:
Sascha Hein, Nuka Ivalu Benz, Jonathan Eisert, Marie-Luise Herrlein, Doris Oberle, Michael Dreher, Julia C. Stingl, Christoph Hildt, Eberhard Hildt
Publikováno v:
Vaccines, Vol 9, Iss 12, p 1419 (2021)
Many of the approved SARS-CoV-2 vaccines are based on a stabilized variant of the spike protein. This raises the question of whether the immune response against the stabilized spike is identical to the immune response that is elicited by the native s
Externí odkaz:
https://doaj.org/article/5b8dc9eb8629433fa02870aea3995256