Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Julia C, LeCher"'
Autor:
Selwyn J. Hurwitz, Ramyani De, Julia C. LeCher, Jessica A. Downs-Bowen, Shu Ling Goh, Keivan Zandi, Tamara McBrayer, Franck Amblard, Dharmeshkumar Patel, James J. Kohler, Manoj Bhasin, Brian S. Dobosh, Vikas Sukhatme, Rabindra M. Tirouvanziam, Raymond F. Schinazi
Publikováno v:
Viruses, Vol 16, Iss 4, p 651 (2024)
Most repurposed drugs have proved ineffective for treating COVID-19. We evaluated median effective and toxic concentrations (EC50, CC50) of 49 drugs, mostly from previous clinical trials, in Vero cells. Ratios of reported unbound peak plasma concentr
Externí odkaz:
https://doaj.org/article/954d72f36177427d91cc4fd8c5a0b6f5
Autor:
Julia C. LeCher, Hope L. Didier, Robert L. Dickson, Lauren R. Slaughter, Juana C. Bejarano, Steven Ho, Scott J. Nowak, Carol A. Chrestensen, Jonathan L. McMurry
Publikováno v:
Cancer Reports, Vol 6, Iss 5, Pp n/a-n/a (2023)
Abstract Background Human papillomavirus (HPV) is the causative agent of nearly all forms of cervical cancer, which can arise upon viral integration into the host genome and concurrent loss of viral regulatory gene E2. Gene‐based delivery approache
Externí odkaz:
https://doaj.org/article/124f97a435f34ac59f4870fd8c16599a
Autor:
Nicolas G. Biteau, Sarah A. Amichai, Niloufar Azadi, Ramyani De, Jessica Downs-Bowen, Julia C. Lecher, Tamara MacBrayer, Raymond F. Schinazi, Franck Amblard
Publikováno v:
Viruses, Vol 15, Iss 2, p 544 (2023)
Over the past decades, both 4′-modified nucleoside and carbocyclic nucleoside analogs have been under the spotlight as several compounds from either family showed anti-HIV, HCV, RSV or SARS-CoV-2 activity. Herein, we designed compounds combining th
Externí odkaz:
https://doaj.org/article/fe6511c73d1e4e1d9ca07bed6f63f6f0
Autor:
Julia C. LeCher, Keivan Zandi, Vivian Vasconcelos Costa, Franck Amblard, Sijia Tao, Dharmeshkumar Patel, Sujin Lee, Felipe Rocha da Silva Santos, Matheus Rodrigues Goncalves, Celso Martins Queroz-Junior, Fernanda Martins Marim, Katie Musall, Shu Ling Goh, Tamara McBrayer, Jessica Downs-Bowen, Ramyani De, Niloufar Azadi, James Kohler, Mauro Martins Teixeira, Raymond F. Schinazi
Publikováno v:
Microorganisms, Vol 10, Iss 11, p 2098 (2022)
Yellow fever virus (YFV) is a potentially lethal, zoonotic, blood-borne flavivirus transmitted to humans and non-human primates by mosquitoes. Owing to multiple deadly epidemics, the WHO classifies YFV as a “high impact, high threat disease” with
Externí odkaz:
https://doaj.org/article/b7afa49fb6e74c87b2b2be789d66b3e8
Autor:
Franck Amblard, Julia C. LeCher, Ramyani De, Shu Ling Goh, Chengwei Li, Mahesh Kasthuri, Nicolas Biteau, Longhu Zhou, Zahira Tber, Jessica Downs-Bowen, Keivan Zandi, Raymond F. Schinazi
Publikováno v:
Pharmaceuticals, Vol 15, Iss 9, p 1144 (2022)
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, an ester prodrug form of N4-hydroxycytidine (NHC), was re
Externí odkaz:
https://doaj.org/article/5b28f39250b449959a136cc3c1d06f07
Autor:
Sijia Tao, Keivan Zandi, Leda Bassit, Yee Tsuey Ong, Kiran Verma, Peng Liu, Jessica A. Downs-Bowen, Tamara McBrayer, Julia C. LeCher, James J. Kohler, Philip R. Tedbury, Baek Kim, Franck Amblard, Stefan G. Sarafianos, Raymond F. Schinazi
Publikováno v:
Current Research in Pharmacology and Drug Discovery, Vol 2, Iss , Pp 100045- (2021)
Remdesivir, a monophosphate prodrug of nucleoside analog GS-441524, is widely used for the treatment of moderate to severe COVID-19. It has been suggested to use GS-441524 instead of remdesivir in the clinic and in new inhalation formulations. Thus,
Externí odkaz:
https://doaj.org/article/d94330ccb3e0445a8d9165b90ad608da
Autor:
Julia C. LeCher, Hope L. Didier, Robert L. Dickson, Lauren R. Slaughter, Juana C. Bejarano, Steven Ho, Scott J. Nowak, Carol A. Chrestensen, Jonathan L. McMurry
Publikováno v:
Cancer Reports. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68954be7f480d153060dd730f62caa2c
https://doi.org/10.1002/cnr2.1810
https://doi.org/10.1002/cnr2.1810
Autor:
Franck, Amblard, Julia C, LeCher, Ramyani, De, Shu Ling, Goh, Chengwei, Li, Mahesh, Kasthuri, Nicolas, Biteau, Longhu, Zhou, Zahira, Tber, Jessica, Downs-Bowen, Keivan, Zandi, Raymond F, Schinazi
Publikováno v:
Pharmaceuticals (Basel, Switzerland). 15(9)
Coronavirus disease 2019 (COVID-19) is an emerging global pandemic with severe morbidity and mortality caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Molnupiravir, an ester prodrug form of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::63af522e05432f7cb7d7994e33bcc0d6
https://pubmed.ncbi.nlm.nih.gov/36145365
https://pubmed.ncbi.nlm.nih.gov/36145365
Publikováno v:
Viruses, Vol 11, Iss 6, p 499 (2019)
Herpes B virus is a deadly zoonotic agent that can be transmitted to humans from the macaque monkey, an animal widely used in biomedical research. Currently, there is no cure for human B virus infection and treatments require a life-long daily regime
Externí odkaz:
https://doaj.org/article/b6215929742043afb1b97bdc4c1c73a4
Autor:
Kathryn Musall, Junkai Yang, Diego Moncada Giraldo, Julia C. LeCher, Vikas P. Sukhatme, Rabindra Tirouvanziam, Devon J. Eddins, Eliver Ghosn, Brian S. Dobosh, Shu Ling Goh, Milagros Aldeco, Keivan Zandi, Vincent D. Giacalone, Raymond F. Schinazi, Manoj Bhasin
Publikováno v:
SSRN Electronic Journal.
COVID-19 patients are generally asymptomatic during initial SARS-CoV-2 replication, but may suffer severe immunopathology after the virus has receded and blood monocytes have infiltrated the airways. In the bronchoalveolar lavage fluid from patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9783a13ae38f7e389212ba76ff5ea939
https://doi.org/10.2139/ssrn.3959287
https://doi.org/10.2139/ssrn.3959287