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Autor:
Veronica Albertini, Sara Napoli, Aklank Jain, Julia Bergant, Carlo V. Catapano, Sara Vignati, Giuseppina M. Carbone, Mohammad Nur-e-Alam, Jürgen Rohr, Ivo Kwee, Andrea Rinaldi, Francesco Bertoni
Publikováno v:
Nucleic Acids Research
The aureolic acid antibiotic mithramycin (MTM) binds selectively to GC-rich DNA sequences and blocks preferentially binding of proteins, like Sp1 transcription factors, to GC-rich elements in gene promoters. Genetic approaches can be applied to alter