Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Julia A. Ju"'
Autor:
Keyata N. Thompson, Julia A. Ju, Eleanor C. Ory, Stephen J. P. Pratt, Rachel M. Lee, Trevor J. Mathias, Katarina T. Chang, Cornell J. Lee, Olga G. Goloubeva, Patrick C. Bailey, Kristi R. Chakrabarti, Christopher M. Jewell, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-21 (2022)
Abstract Clinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the metastatic phenotypes of microtentacles, reattachment and tumor cell clustering more than tumor
Externí odkaz:
https://doaj.org/article/16b3a6a66cbd4783a10d41a52c7ae93f
Autor:
Vasileios Vardas, Julia A. Ju, Athina Christopoulou, Anastasia Xagara, Vassilis Georgoulias, Athanasios Kotsakis, Catherine Alix-Panabières, Stuart S. Martin, Galatea Kallergi
Publikováno v:
Cells, Vol 12, Iss 15, p 1940 (2023)
Metastasis, rather than the growth of the primary tumor, accounts for approximately 90% of breast cancer patient deaths. Microtentacles (McTNs) formation represents an important mechanism of metastasis. Triple-negative breast cancer (TNBC) is the mos
Externí odkaz:
https://doaj.org/article/3b5941a6f1cd4905b7f87e5dede30642
Autor:
Lekhana Bhandary, Patrick C. Bailey, Katarina T. Chang, Karen F. Underwood, Cornell J. Lee, Rebecca A. Whipple, Christopher M. Jewell, Eleanor Ory, Keyata N. Thompson, Julia A. Ju, Trevor M. Mathias, Stephen J. P. Pratt, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Mammosphere assays are widely used in vitro to identify prospective cancer-initiating stem cells that can propagate clonally to form spheres in free-floating conditions. However, the traditional mammosphere assay inevitably introduces cell a
Externí odkaz:
https://doaj.org/article/7fa9e6ad3962419dbe47d6107797d52b
Autor:
Megan B. Stemberger, Julia A. Ju, Keyata N. Thompson, Trevor J. Mathias, Alexandra E. Jerrett, Katarina T. Chang, Eleanor C. Ory, David A. Annis, Makenzy L. Mull, Darin E. Gilchrist, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Cells, Vol 12, Iss 9, p 1266 (2023)
Levels of hydrogen peroxide are highly elevated in the breast tumor microenvironment compared to normal tissue. Production of hydrogen peroxide is implicated in the mechanism of action of many anticancer therapies. Several lines of evidence suggest h
Externí odkaz:
https://doaj.org/article/fff120d70ebf46c392e1750ff30f723f
Autor:
Katarina T. Chang, Keyata N. Thompson, Stephen J. P. Pratt, Julia A. Ju, Rachel M. Lee, Trevor J. Mathias, Makenzy L. Mull, David A. Annis, Eleanor C. Ory, Megan B. Stemberger, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Cancers, Vol 15, Iss 3, p 884 (2023)
Cytoskeletal remodeling in circulating tumor cells (CTCs) facilitates metastatic spread. Previous oncology studies examine sustained aberrant calcium (Ca2+) signaling and cytoskeletal remodeling scrutinizing long-term phenotypes such as tumorigenesis
Externí odkaz:
https://doaj.org/article/246052652eec4a51a1c2f6d1aae3e91e
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Hypoxia is known to promote tumor progression. Here, the authors evaluate hypoxic cells using a fate mapping approach and identify a distinct gene expression profile of cells exposed to intratumoral hypoxia and show that post-hypoxic tumor cells have
Externí odkaz:
https://doaj.org/article/a5f1f8419ccf4c21aec6a8ada0d7c50b
Autor:
Trevor J. Mathias, Julia A. Ju, Rachel M. Lee, Keyata N. Thompson, Makenzy L. Mull, David A. Annis, Katarina T. Chang, Eleanor C. Ory, Megan B. Stemberger, Takashi Hotta, Ryoma Ohi, Michele I. Vitolo, Marie-Jo Moutin, Stuart S. Martin
Publikováno v:
Cancers, Vol 14, Iss 7, p 1707 (2022)
Post-translational modifications (PTMs) of the microtubule network impart differential functions across normal cell types and their cancerous counterparts. The removal of the C-terminal tyrosine of α-tubulin (deTyr-Tub) as performed by the tubulin c
Externí odkaz:
https://doaj.org/article/a9e03d3afcd844afa649f9b0461c12df
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1646 (2020)
Long noncoding RNA differentiation antagonizing nonprotein coding RNA (lncRNA-DANCR) is associated with poor prognosis in multiple cancers, and promotes cancer stemness and invasion. However, the exact mechanisms by which DANCR promotes non-small cel
Externí odkaz:
https://doaj.org/article/31ecd7236ba549ddab180d0bde000ea0
Autor:
Julia A. Ju, Daniele M. Gilkes
Publikováno v:
Genes, Vol 9, Iss 2, p 67 (2018)
Although Rho GTPases RhoA, RhoB, and RhoC share more than 85% amino acid sequence identity, they play very distinct roles in tumor progression. RhoA and RhoC have been suggested in many studies to contribute positively to tumor development, but the r
Externí odkaz:
https://doaj.org/article/31fc022d6c42448e8e9da0773558672f
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2020 Oct . 117(43), 26804-26811.
Externí odkaz:
https://www.jstor.org/stable/26970628