Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Julia A Ju"'
Autor:
Donald A Belcher, Julia A Ju, Jin Hyen Baek, Ayla Yalamanoglu, Paul W Buehler, Daniele M Gilkes, Andre F Palmer
Publikováno v:
PLoS ONE, Vol 13, Iss 2, p e0191275 (2018)
A major constraint in the treatment of cancer is inadequate oxygenation of the tumor mass, which can reduce chemotherapeutic efficacy. We hypothesize that polymerized human hemoglobin (PolyhHb) can be transfused into the systemic circulation to incre
Externí odkaz:
https://doaj.org/article/db402f0e3f0b4bf1b7da163fb38606ff
Autor:
Keyata N. Thompson, Julia A. Ju, Eleanor C. Ory, Stephen J. P. Pratt, Rachel M. Lee, Trevor J. Mathias, Katarina T. Chang, Cornell J. Lee, Olga G. Goloubeva, Patrick C. Bailey, Kristi R. Chakrabarti, Christopher M. Jewell, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-21 (2022)
Abstract Clinical cancer imaging focuses on tumor growth rather than metastatic phenotypes. The microtubule-depolymerizing drug, Vinorelbine, reduced the metastatic phenotypes of microtentacles, reattachment and tumor cell clustering more than tumor
Externí odkaz:
https://doaj.org/article/16b3a6a66cbd4783a10d41a52c7ae93f
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2020 Oct . 117(43), 26804-26811.
Externí odkaz:
https://www.jstor.org/stable/26970628
Autor:
Vasileios Vardas, Julia A. Ju, Athina Christopoulou, Anastasia Xagara, Vassilis Georgoulias, Athanasios Kotsakis, Catherine Alix-Panabières, Stuart S. Martin, Galatea Kallergi
Publikováno v:
Cells, Vol 12, Iss 15, p 1940 (2023)
Metastasis, rather than the growth of the primary tumor, accounts for approximately 90% of breast cancer patient deaths. Microtentacles (McTNs) formation represents an important mechanism of metastasis. Triple-negative breast cancer (TNBC) is the mos
Externí odkaz:
https://doaj.org/article/3b5941a6f1cd4905b7f87e5dede30642
Autor:
Megan B. Stemberger, Julia A. Ju, Keyata N. Thompson, Trevor J. Mathias, Alexandra E. Jerrett, Katarina T. Chang, Eleanor C. Ory, David A. Annis, Makenzy L. Mull, Darin E. Gilchrist, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Cells, Vol 12, Iss 9, p 1266 (2023)
Levels of hydrogen peroxide are highly elevated in the breast tumor microenvironment compared to normal tissue. Production of hydrogen peroxide is implicated in the mechanism of action of many anticancer therapies. Several lines of evidence suggest h
Externí odkaz:
https://doaj.org/article/fff120d70ebf46c392e1750ff30f723f
Autor:
Lekhana Bhandary, Patrick C. Bailey, Katarina T. Chang, Karen F. Underwood, Cornell J. Lee, Rebecca A. Whipple, Christopher M. Jewell, Eleanor Ory, Keyata N. Thompson, Julia A. Ju, Trevor M. Mathias, Stephen J. P. Pratt, Michele I. Vitolo, Stuart S. Martin
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Mammosphere assays are widely used in vitro to identify prospective cancer-initiating stem cells that can propagate clonally to form spheres in free-floating conditions. However, the traditional mammosphere assay inevitably introduces cell a
Externí odkaz:
https://doaj.org/article/7fa9e6ad3962419dbe47d6107797d52b
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2019 Apr . 116(17), 8390-8396.
Externí odkaz:
https://www.jstor.org/stable/26703516
Autor:
Kumar Sachin Singh, Julia I-Ju Leu, Thibaut Barnoud, Prashanthi Vonteddu, Keerthana Gnanapradeepan, Cindy Lin, Qin Liu, James C. Barton, Andrew V. Kossenkov, Donna L. George, Maureen E. Murphy, Farokh Dotiwala
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
A polymorphism in human TP53 (P47S) that predominantly exists in individuals of African descent affects ferroptosis. Here, the authors show that this results in iron accumulation in macrophages leading to more productive infection by intracellular ba
Externí odkaz:
https://doaj.org/article/2d5a574431c94fcbb245e3571e64248d
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Hypoxia is known to promote tumor progression. Here, the authors evaluate hypoxic cells using a fate mapping approach and identify a distinct gene expression profile of cells exposed to intratumoral hypoxia and show that post-hypoxic tumor cells have
Externí odkaz:
https://doaj.org/article/a5f1f8419ccf4c21aec6a8ada0d7c50b
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)
The tumor protein P53 (TP53, or p53) has complex and at times seemingly contradictory roles in the regulation of metabolism and ferroptosis sensitivity. We find that the actions of p53 influence the redox state, which can trigger changes in redox-sen
Externí odkaz:
https://doaj.org/article/d59e66c600164c3ab3a02c6616a35f21