Zobrazeno 1 - 10
of 303
pro vyhledávání: '"Julia A Elvin"'
Autor:
Douglas I. Lin, Julia C. F. Quintanilha, Natalie Danziger, Lixin Lang, Diane Levitan, Cynthia Hayne, Matthew C. Hiemenz, David L. Smith, Lee A. Albacker, Jeffrey Leibowitz, Douglas A. Mata, Brennan Decker, Sotirios Lakis, Nimesh R. Patel, Ryon P. Graf, Julia A. Elvin, Jeffrey S. Ross, Varun Pattani, Richard S. P. Huang, Amy K. Wehn
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-9 (2024)
Abstract Microsatellite instability high (MSI-H) and mismatch repair deficient (dMMR) tumor status have been demonstrated to predict patient response to immunotherapies. We developed and validated a next-generation sequencing (NGS)-based companion di
Externí odkaz:
https://doaj.org/article/5b1f54d32e854c9184c1c038f53bf3c6
Autor:
Jenny L. Soiffer, Alexander J. Fife, Shrikanth S. Gadad, Javier A. Laurini, Julia A. Elvin, Sara S. Isani, Ken Y. Lin
Publikováno v:
Gynecologic Oncology Reports, Vol 54, Iss , Pp 101426- (2024)
Externí odkaz:
https://doaj.org/article/0686fd3ebf9a4c51bdc76ea750ce2e73
Autor:
Douglas I. Lin, Richard S. P. Huang, Ioannis Ladas, Rachel B. Keller, Nimesh R. Patel, Sotirios Lakis, Brennan Decker, Tyler Janovitz, Douglas A. Mata, Jeffrey S. Ross, Jo-Anne Vergilio, Julia A. Elvin, Roy S. Herbst, Philip C. Mack, Jonathan K. Killian
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundWhile many molecular assays can detect mutations at low tumor purity and variant allele frequencies, complex biomarkers such as tumor mutational burden (TMB), microsatellite instability (MSI), and genomic loss of heterozygosity (gLOH) requi
Externí odkaz:
https://doaj.org/article/f00911dcecc04bac98bd66bb18ec2b34
Autor:
Razelle Kurzrock, Karthikeyan Murugesan, Denis Leonardo Jardim, Julia A. Elvin, Richard S. P. Huang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 2 (2023)
PD-L1 (CD274) amplification occurs in a small subset of malignancies and may predict anti-PD-1/PD-L1 immunotherapy responsiveness. We hypothesized that both copy number (CN) and focality of cancer-related PD-L1 amplifications impact protein expressio
Externí odkaz:
https://doaj.org/article/885bd30952144769b34ef6b58a9fafb9
Autor:
Nathan D. Seligson, Joy Tang, Dexter X. Jin, Monica P. Bennett, Julia A. Elvin, Kiley Graim, John L. Hays, Sherri Z. Millis, Wayne O. Miles, James L. Chen
Publikováno v:
npj Precision Oncology, Vol 6, Iss 1, Pp 1-8 (2022)
Abstract Leiomyosarcoma (LMS) is a rare, aggressive, mesenchymal tumor. Subsets of LMS have been identified to harbor genomic alterations associated with homologous recombination deficiency (HRD); particularly alterations in BRCA2. Whereas genomic lo
Externí odkaz:
https://doaj.org/article/5569dd97949b45d193253fac2db06235
Autor:
Andrea Necchi, Giuseppe Basile, Filippo Pederzoli, Marco Bandini, Petros Grivas, Gennady Bratslavsky, Philippe E. Spiess, J. Keith Killian, Douglas I. Lin, Erik Williams, Shakti Ramkissoon, Eric A. Severson, Brian M. Alexander, Jeffrey Venstrom, Prasanth Reddy, Kimberley McGregor, Julia A. Elvin, Alexa B. Schrock, Dean V. Pavlick, Dexter X. Jin, Sally E. Trabucco, Natalie Danzinger, Jeffrey S. Ross
Publikováno v:
Société Internationale d’Urologie Journal, Vol 2, Iss 4, Pp 216-228 (2021)
BackgroundAdult primary retroperitoneal sarcomas (RPSs) are a group of heterogeneous tumors with different histological subtypes. Comprehensive genomic profiling (CGP) analyses have recently provided significant insights into the biology of sarcomas
Externí odkaz:
https://doaj.org/article/25378e6a34274358be41fcc2afedd659
Autor:
Elizabeth M. Swisher, Tanya T. Kwan, Amit M. Oza, Anna V. Tinker, Isabelle Ray-Coquard, Ana Oaknin, Robert L. Coleman, Carol Aghajanian, Gottfried E. Konecny, David M. O’Malley, Alexandra Leary, Diane Provencher, Stephen Welch, Lee-may Chen, Andrea E. Wahner Hendrickson, Ling Ma, Prafull Ghatage, Rebecca S. Kristeleit, Oliver Dorigo, Ashan Musafer, Scott H. Kaufmann, Julia A. Elvin, Douglas I. Lin, Setsuko K. Chambers, Erin Dominy, Lan-Thanh Vo, Sandra Goble, Lara Maloney, Heidi Giordano, Thomas Harding, Alexander Dobrovic, Clare L. Scott, Kevin K. Lin, Iain A. McNeish
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The identification of biomarkers of response to PARP inhibitors can enable selection of appropriate ovarian cancer patients for treatment. In this study, the authors report clinical results and exploratory biomarker analyses from the ARIEL2 phase 2 c
Externí odkaz:
https://doaj.org/article/4c0bb318d2464bacb5fcd01f6ceefda3
Autor:
Douglas I. Lin, Nikunj Shah, Julie Y. Tse, Jonathan K. Killian, Amanda Hemmerich, Claire Edgerly, James Haberberger, Eric A. Severson, Richard S.P. Huang, Shakti H. Ramkissoon, Jo-Anne Vergilio, Jeffrey S. Ross, Julia A. Elvin
Publikováno v:
Gynecologic Oncology Reports, Vol 34, Iss , Pp 100652- (2020)
Mesonephric carcinoma is a rare cancer that most often arises within the cervix, and less frequently, in the ovary and endometrium. A retrospective search of our CLIA-certified and CAP-accredited reference molecular laboratory database (Foundation Me
Externí odkaz:
https://doaj.org/article/084d9ff953d44eab8571217dce0682cc
Autor:
Eva J. Gordon, David Parker, Kelly Barth, Jennifer Pena, Julia A. Elvin, Thomas DeLeon, Nina J. Karlin
Publikováno v:
Case Reports in Oncology, Vol 11, Iss 2, Pp 399-403 (2018)
Mutations or other alterations in the RET gene have been implicated in a variety of malignancies – most commonly thyroid, but also chronic myelomonocytic leukemia, acute myeloid leukemia, and lung, breast, pancreatic, and colon cancers. Here we pre
Externí odkaz:
https://doaj.org/article/e8f337965fe64b108d7a07d234358547
Publikováno v:
Gynecologic Oncology Reports, Vol 21, Iss C, Pp 57-60 (2017)
Externí odkaz:
https://doaj.org/article/30e42dc95f4f4dac997c54619bff0e45