Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline

Autor: Julia Stockmann, Inge M. W. Verberk, Nina Timmesfeld, Robin Denz, Brian Budde, Julia Lange-Leifhelm, Philip Scheltens, Wiesje M. van der Flier, Andreas Nabers, Charlotte E. Teunissen, Klaus Gerwert

Publikováno v: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2020)

Abstract Background We evaluated Aβ misfolding in combination with Aβ42/40 ratio as a prognostic tool for future clinical progression to mild cognitive impairment (MCI) or dementia due to Alzheimer’s disease (AD) in individuals with subjective co

Externí odkaz: https://doaj.org/article/01b9f2a3ace648689f1dd585d885dfe9

Amyloid‐beta misfolding and GFAP predict risk of clinical Alzheimer's disease diagnosis within 17 years

Autor: Léon, Beyer, Hannah, Stocker, Dan, Rujescu, Bernd, Holleczek, Julia, Stockmann, Andreas, Nabers, Hermann, Brenner, Klaus, Gerwert

Publikováno v: Alzheimer's & Dementia. 19:1020-1028

Blood-based biomarkers for Alzheimer's disease (AD) are urgently needed. Here, four plasma biomarkers were measured at baseline in a community-based cohort followed over 17 years, and the association with clinical AD risk was determined.Amyloid beta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59ea9874adb2004f090d1855e4460a8
https://doi.org/10.1002/alz.12745

Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline

Autor: Philip Scheltens, Nina Timmesfeld, Inge M.W. Verberk, Brian Budde, Julia Stockmann, Charlotte E. Teunissen, Andreas Nabers, Julia Lange-Leifhelm, Wiesje M. van der Flier, Klaus Gerwert, Robin Denz

Publikováno v: Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2020)
Stockmann, J, Verberk, I M W, Timmesfeld, N, Denz, R, Budde, B, Lange-Leifhelm, J, Scheltens, P, van der Flier, W M, Nabers, A, Teunissen, C E & Gerwert, K 2020, ' Amyloid-β misfolding as a plasma biomarker indicates risk for future clinical Alzheimer’s disease in individuals with subjective cognitive decline ', Alzheimer's Research and Therapy, vol. 12, no. 1, 169 . https://doi.org/10.1186/s13195-020-00738-8
Alzheimer's Research & Therapy
Alzheimer's Research and Therapy, 12(1):169. BioMed Central

Background We evaluated Aβ misfolding in combination with Aβ42/40 ratio as a prognostic tool for future clinical progression to mild cognitive impairment (MCI) or dementia due to Alzheimer’s disease (AD) in individuals with subjective cognitive d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdaad83a0f687f039609af27af760f1e
https://doaj.org/article/01b9f2a3ace648689f1dd585d885dfe9

Discovery of three novel sesquiterpene synthases from Streptomyces chartreusis NRRL 3882 and crystal structure of an α-eudesmol synthase

Autor: Christoph Helmut Rudi Senges, Robert Kourist, Raquel S. Correia Cordeiro, Dennis Sander, Julia Stockmann, Derek T. Logan, Maria Håkansson, Julia E. Bandow, Octavia Natascha Kracht

Publikováno v: Journal of Biotechnology. 297:71-77

With more than 50,000 members, terpenoids are one of the most important classes of natural products and show an enormous diversity. Due to their unique odors and specific bioactivities they already find wide application in the flavor, fragrance and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c12d1d8e38a1d31ccf5ba9a159049a
https://doi.org/10.1016/j.jbiotec.2019.03.006

Genetic predisposition, Aβ misfolding in blood plasma, and Alzheimer's disease

Autor: Andreas Nabers, Hannah Stocker, Julia Stockmann, Ben Schöttker, Tobias Möllers, Bernd Holleczek, Annette M. Hartmann, Dan Rujescu, Hermann Brenner, Laura Perna, Klaus Gerwert

Publikováno v: Translational Psychiatry
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)

Alzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique marker of A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a865ed7f47a98a95b4cea8df1844e6cc
https://pubmed.ncbi.nlm.nih.gov/33934115