Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Julia, Przibilla"'
Autor:
Mohanraj Gopalswamy, Tobias Kroeger, David Bickel, Benedikt Frieg, Shahina Akter, Stephan Schott-Verdugo, Aldino Viegas, Thomas Pauly, Manuela Mayer, Julia Przibilla, Jens Reiners, Luitgard Nagel-Steger, Sander H. J. Smits, Georg Groth, Manuel Etzkorn, Holger Gohlke
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-18 (2022)
Abstract Acute myeloid leukemia (AML) is a malignant disease of immature myeloid cells and the most prevalent acute leukemia among adults. The oncogenic homo-tetrameric fusion protein RUNX1/ETO results from the chromosomal translocation t(8;21) and i
Externí odkaz:
https://doaj.org/article/aeaec08cbc53466ab4dd597d8162db4f
Autor:
Thi-Phuong Tao, Ilka Maschmeyer, Edward L. LeCluyse, Eda Rogers, Katrin Brandmair, Silke Gerlach, Julia Przibilla, Fredy Kern, Camille Genies, Carine Jacques, Abdulkarim Najjar, Andreas Schepky, Uwe Marx, Jochen Kühnl, Nicola J. Hewitt
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
All cosmetic ingredients registered in Europe must be evaluated for their safety using non-animal methods. Microphysiological systems (MPS) offer a more complex higher tier model to evaluate chemicals. Having established a skin and liver HUMIMIC Chip
Externí odkaz:
https://doaj.org/article/5068186205ee485da21ca6a4409cc5d3
Autor:
Ilka Maschmeyer, Julia Przibilla, Thi Phuong Tao, Camille Genies, Carine Jacques-Jamin, Andreas Schepky, Uwe Marx, Katrin Brandmair, Nicola J. Hewitt, Jochen Kühnl, Silke Gerlach
Publikováno v:
Journal of Applied Toxicology. 41:1553-1567
We used TissUse's HUMIMIC Chip2 microfluidic model, incorporating reconstructed skin models and liver spheroids, to investigate the impact of consumer-relevant application scenarios on the metabolic fate of the hair dye, 4-amino-2-hydroxytoluene (AHT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20001faf92cda0c6cc4e81a1c2453cca
https://doi.org/10.1002/jat.4146
https://doi.org/10.1002/jat.4146
Autor:
Vincenzo Davide Aloi, Yu Tian Wang, Katharina Held, Annelies Janssens, Stephan E. Philipp, Ana Cristina Nogueira Freitas, Thomas Voets, Joris Vriens, Julia Przibilla, Andrei Segal
Publikováno v:
British Journal of Pharmacology. 179:3560-3575
BACKGROUND AND PURPOSE: Transient receptor potential melastatin 3 (TRPM3) is a non-selective cation channel that plays a pivotal role in the peripheral nervous system as a transducer of painful heat signals. Alternative splicing gives rise to several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca8fdbf99817aa007700372e42349698
https://doi.org/10.1111/bph.15223
https://doi.org/10.1111/bph.15223
Autor:
Mohanraj Gopalswamy, Tobias Kroeger, David Bickel, Benedikt Frieg, Shahina Akter, Stephan Schott-Verdugo, Aldino Viegas, Thomas Pauly, Manuela Mayer, Julia Przibilla, Jens Reiners, Luitgard Nagel-Steger, Sander H. J. Smits, Georg Groth, Manuel Etzkorn, Holger Gohlke
Publikováno v:
Scientific reports 12(1), 14158 (2022). doi:10.1038/s41598-022-17913-6
Funding Information: This work was supported by a grant by the state of North-Rhine Westphalia and the European Fonds for Regional Development EFRE.NRW 2014-2020 to HG. We are grateful for computational support and infrastructure provided by the “Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c39a287f5795cbff9a81a2f4f468e4a
https://doi.org/10.1101/2021.12.22.473911
https://doi.org/10.1101/2021.12.22.473911
Autor:
Nicola J. Hewitt, John Troutman, Julia Przibilla, Andreas Schepky, Gladys Ouédraogo, Catherine Mahony, Gerry Kenna, Mustafa Varçin, Mathew P. Dent
Publikováno v:
Regulatory Toxicology and Pharmacology. 131:105132
A novel approach was developed to help characterize the biokinetics of the cosmetic ingredient, phenoxyethanol, to help assess the safety of the parent and its major stable metabolite. In the first step of this non-animal tiered approach, primary hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d44e5cbbed969e3412b051dc7b37a3
https://doi.org/10.1016/j.yrtph.2022.105132
https://doi.org/10.1016/j.yrtph.2022.105132
Autor:
Andreas Beck, Julia Przibilla, Johannes Oberwinkler, Annette Lis, Oleksandr Rizun, Martin Jung, Sandeep Dembla, Stephan E. Philipp
Publikováno v:
Cell Calcium. 73:40-52
TRPM3 proteins assemble to Ca2+-permeable cation channels in the plasma membrane, which act as nociceptors of noxious heat and mediators of insulin and cytokine release. Here we show that TRPM3 channel activity is strongly dependent on intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8ec22df2c46117d03383236135c0117
https://doi.org/10.1016/j.ceca.2018.03.005
https://doi.org/10.1016/j.ceca.2018.03.005
Autor:
Uwe Marx, Camille Genies, Julia Przibilla, Silke Gerlach, Nicola J. Hewitt, Thamée Rings, Katrin Brandmair, Ursula Müller-Vieira, Thi Phuong Tao, Ilka Maschmeyer, Jochen Kühnl, Andreas Schepky, Carine Jaques-Jamin
Publikováno v:
Toxicology. 448:152637
Microphysiological systems (MPS) aim to mimic the dynamic microenvironment and the interaction between tissues. While MPS exist for investigating pharmaceuticals, the applicability of MPS for cosmetics ingredients is yet to be evaluated. The HUMIMIC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b05ca619dc6c326ff27f16dd8223733
https://doi.org/10.1016/j.tox.2020.152637
https://doi.org/10.1016/j.tox.2020.152637
Autor:
Julia, Przibilla, Sandeep, Dembla, Oleksandr, Rizun, Annette, Lis, Martin, Jung, Johannes, Oberwinkler, Andreas, Beck, Stephan E, Philipp
Publikováno v:
Cell calcium. 73
TRPM3 proteins assemble to Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25a5f5ca4dc96daea825e6ff6a09ec3b
https://pubmed.ncbi.nlm.nih.gov/29880196
https://pubmed.ncbi.nlm.nih.gov/29880196