Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Julia, Kristensson"'
Autor:
Jun Ma, Kristen Hurov, Johanna lahdenranta, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Eric Haines, Kevin McDonnell, Philip Brandish, Nicholas Keen, Fanglei You, Mike Kelly, Heather Cohen, Drasti Kanakia, Carly Campbell, David Witty, Stephen Blakemore, Phil Jeffrey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 11 (2021)
Externí odkaz:
https://doaj.org/article/4724c01b9ec7407d90abf3570e647883
Autor:
Kristen Hurov, Johanna lahdenranta, Gemma Mudd, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Kevin McDonnell, Philip Brandish, Nicholas Keen, Phil Jeffrey
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/6414f70ad96342768354adee2801717c
Autor:
Sailaja Battula, Kristen Hurov, Johanna lahdenranta, Gemma Mudd, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Marianna Kleyman, Jessica Kublin, Liuhong Chen, Eric Haines, Kevin McDonnell, Philip Brandish, Nicholas Keen, Rachel Dods, Rachid Lani, Katerine Van Rietschoten, Tom Stephen, Fanglei You
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background In contrast to immune checkpoint inhibitors, the use of antibodies as agonists of immune costimulatory receptors as cancer therapeutics has largely failed. We sought to address this problem using a new class of modular synthetic drugs, ter
Externí odkaz:
https://doaj.org/article/2beebb8f72534439867cc69dff340982
Autor:
Jun Ma, Sailaja Battula, Kristen Hurov, Johanna lahdenranta, Gemma Mudd, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Marianna Kleyman, Jessica Kublin, Liuhong Chen, Eric Haines, Kevin McDonnell, Philip Brandish, Nicholas Keen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/6541410690f84d4cbbca57e8c0959953
Autor:
Kristen Hurov, Lia Luus, Johanna Lahdenranta, Punit Upadhyaya, Heather Cohen, Chinmayee Shah, Julia Kristensson, Peter Brown, Gemma Mudd, Carly Campbell, Elizabeth Repash, Eric Haines, Sailaja Battula, Mike Kelly, Phil Jeffrey, Paul Beswick, Liuhong Chen, Kevin McDonnell, Philip Brandish, Nicholas Keen
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f969126e40fad5d1270f04621dffbb4
https://doi.org/10.1136/jitc-2022-sitc2022.1340
https://doi.org/10.1136/jitc-2022-sitc2022.1340
Autor:
Punit Upadhyaya, Julia Kristensson, Johanna Lahdenranta, Elizabeth Repash, Jun Ma, Jessica Kublin, Gemma E. Mudd, Lia Luus, Phil Jeffrey, Kristen Hurov, Kevin McDonnell, Nicholas Keen
Publikováno v:
Journal of medicinal chemistry. 65(14)
CD137 (4-1BB) is a co-stimulatory receptor on immune cells and Nectin-4 is a cell adhesion molecule that is overexpressed in multiple tumor types. Using a series of poly(ethylene glycol) (PEG)-based linkers, synthetic bicyclic peptides targeting CD13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c27610ba02170186a7dd0cfd287a4aa
https://pubmed.ncbi.nlm.nih.gov/35819182
https://pubmed.ncbi.nlm.nih.gov/35819182
Autor:
Lia Luus, Kristen Hurov, Johanna Lahdenranta, Chinmayee Shah, Anna Devlen, Julia Kristensson, Peter Brown, Cara Bray, Heather Cohen, Carly Campbell, Gemma Mudd, Punit Upadhyaya, Kevin McDonnell, Hongmei Xu, Phil Jeffrey, Philip E. Brandish, Nicholas Keen
Publikováno v:
Cancer Research. 83:1832-1832
We have developed a new class of modular synthetic drugs, termed Bicycle® tumor-targeted immune cell agonists (Bicycle® TICAs), which are multi-specific molecules composed of constrained bicyclic peptides (Bicycles)1. The first molecule of this cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46754c475147f5c4c10bcd415df05928
https://doi.org/10.1158/1538-7445.am2023-1832
https://doi.org/10.1158/1538-7445.am2023-1832
Autor:
Heather Cohen, Cara Bray, Drasti Kanakia, Johanna Lahdenranta, Punit Upadhyaya, Kristen Hurov, Julia Kristensson, Chintan Jobaliya, Greg Bannish, Adam Cotty, Kevin McDonnell, Sandra Hirschberg, Sebastien Hazard, Dominic Smethurst, Nicholas Keen, Stephen J Blakemore
Publikováno v:
Cancer Immunology Research. 10:A65-A65
Bicycles are fully synthetic constrained peptides with antibody-like affinities that target selectively, readily penetrate tumor tissue, have relatively short half-lives, and can be chemically linked together to generate multifunctional molecules. BT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::713348767a05a2757f65c43c1c7bd960
https://doi.org/10.1158/2326-6074.tumimm22-a65
https://doi.org/10.1158/2326-6074.tumimm22-a65
Autor:
Kristen, Hurov, Johanna, Lahdenranta, Punit, Upadhyaya, Eric, Haines, Heather, Cohen, Elizabeth, Repash, Drasti, Kanakia, Jun, Ma, Julia, Kristensson, Fanglei, You, Carly, Campbell, David, Witty, Mike, Kelly, Stephen, Blakemore, Phil, Jeffrey, Kevin, McDonnell, Philip, Brandish, Nicholas, Keen
Publikováno v:
Journal for Immunotherapy of Cancer
Background CD137 (4-1BB) is an immune costimulatory receptor with high therapeutic potential in cancer. We are creating tumor target-dependent CD137 agonists using a novel chemical approach based on fully synthetic constrained bicyclic peptide (Bicyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4e1d5371e1c2ab609b1f42b7db38751b
https://pubmed.ncbi.nlm.nih.gov/34725211
https://pubmed.ncbi.nlm.nih.gov/34725211
Autor:
Fay J. Dufort, Christopher J. Leitheiser, Gemma Mudd, Julia Kristensson, Alexandra Rezvaya, Katie Gaynor, Sandra Uhlenbroich, Liudvikas Urbonas, Heather Scott, Liuhong Chen, Helen Harrison, Michael Skynner, Kevin McDonnell, Philip E. Brandish, Nicholas Keen
Publikováno v:
Cancer Research. 82:4233-4233
The tumor specific activation of natural killer (NK) cells is an area of active investigation in immune oncology, but to date has relied on complex biologic modalities (e.g., antibodies, fusion proteins, or cell therapies). NK cells are highly respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b6e8e1ad3bf834d9ee56fc1093ff786
https://doi.org/10.1158/1538-7445.am2022-4233
https://doi.org/10.1158/1538-7445.am2022-4233