Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Julia, Gorelik"'
Autor:
Qianqian Song, Anita Alvarez-Laviada, Sarah E. Schrup, Benedict Reilly-O’Donnell, Emilia Entcheva, Julia Gorelik
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract We present a novel framework, Opto-SICM, for studies of cellular interactions in live cells with high spatiotemporal resolution. The approach combines scanning ion conductance microscopy, SICM, and cell-type-specific optogenetic interrogatio
Externí odkaz:
https://doaj.org/article/b4bc18664cbd4e28900c83e810883c69
Autor:
Aleksandra Judina, Marili Niglas, Vladislav Leonov, Nicholas S. Kirkby, Ivan Diakonov, Peter T. Wright, Lan Zhao, Jane A. Mitchell, Julia Gorelik
Publikováno v:
Cells, Vol 12, Iss 23, p 2764 (2023)
(1) Pulmonary hypertension (PH)-associated right ventricular (RV) failure is linked to a reduction in pulmonary vasodilators. Treprostinil has shown effectiveness in PAH patients with cardiac decompensation, hinting at potential cardiac benefits. We
Externí odkaz:
https://doaj.org/article/d9c9e0ef31eb4ac383dcf8f7feb383b1
Autor:
Raquel Nunez‐Toldra, Thomas Kirwin, Elisa Ferraro, Fotios G. Pitoulis, Laura Nicastro, Ifigeneia Bardi, Worrapong Kit‐Anan, Julia Gorelik, Andre R. Simon, Cesare M. Terracciano
Publikováno v:
ESC Heart Failure, Vol 9, Iss 2, Pp 1400-1412 (2022)
Abstract Aims Altered mechanical load in response to injury is a main driver of myocardial interstitial fibrosis. No current in vitro model can precisely modulate mechanical load in a multicellular environment while maintaining physiological behaviou
Externí odkaz:
https://doaj.org/article/26913f30b9034df698ce567a3d902858
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Background: The increased risk of post-menopausal women developing abnormalities of heart function emphasises the requirement to understand the effect of declining oestrogen levels on cardiac electrophysiology and structure, and investigate possible
Externí odkaz:
https://doaj.org/article/11d4aaa2e9674035aa8c18bdb6de14a3
Autor:
Alexander Kondrashov, Nurul A.N. Mohd Yusof, Alveera Hasan, Joëlle Goulding, Thusharika Kodagoda, Duc M. Hoang, Nguyen T.N. Vo, Tony Melarangi, Nazanin Dolatshad, Julia Gorelik, Stephen J. Hill, Sian E. Harding, Chris Denning
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 39-53 (2021)
During normal- and patho-physiological situations, the behavior of the beta2-adrenoreceptor (β2AR) is influenced by polymorphic variants. The functional impact of such polymorphisms has been suggested from data derived from genetic association studi
Externí odkaz:
https://doaj.org/article/63fcae800ab4494e927ca2eba3c4b859
Autor:
Roman Y. Medvedev, Jose L. Sanchez-Alonso, Catherine A. Mansfield, Aleksandra Judina, Alice J. Francis, Christina Pagiatakis, Natalia Trayanova, Alexey V. Glukhov, Michele Miragoli, Giuseppe Faggian, Julia Gorelik
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Right ventricle (RV) dysfunction is an independent predictor of patient survival in heart failure (HF). However, the mechanisms of RV progression towards failing are not well understood. We studied cellular mechanisms of RV remodelling in a
Externí odkaz:
https://doaj.org/article/81a2436481b242fbb548723b0ffe659f
Autor:
Elisa Ferraro, Lidia Pozhidaeva, David S. Pitcher, Catherine Mansfield, Jia Han Benjamin Koh, Catherine Williamson, Oleg Aslanidi, Julia Gorelik, Fu Siong Ng
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Acute myocardial ischaemia and reperfusion (I–R) are major causes of ventricular arrhythmias in patients with a history of coronary artery disease. Ursodeoxycholic acid (UDCA) has previously been shown to be antiarrhythmic in fetal hearts.
Externí odkaz:
https://doaj.org/article/78d9b779398c45159eddde8c4749c272
Publikováno v:
Cells, Vol 12, Iss 3, p 461 (2023)
Calcium (Ca2+) can regulate a wide variety of cellular fates, such as proliferation, apoptosis, and autophagy. More importantly, changes in the intracellular Ca2+ level can modulate signaling pathways that control a broad range of physiological as we
Externí odkaz:
https://doaj.org/article/5b316f00b7e744799c3b6b372ad0c73e
Autor:
Maria Faleeva, Ivan Diakonov, Prashant Srivastava, Masoud Ramuz, Gaia Calamera, Kjetil Wessel Andressen, Nadja Bork, Lorenza Tsansizi, Marie-Victoire Cosson, Andreia Sofia Bernardo, Viacheslav Nikolaev, Julia Gorelik
Publikováno v:
Cells, Vol 11, Iss 20, p 3257 (2022)
The therapeutic benefit of stimulating the cGMP pathway as a form of treatment to combat heart failure, as well as other fibrotic pathologies, has become well established. However, the development and signal compartmentation of this crucial pathway h
Externí odkaz:
https://doaj.org/article/da1e9dac2d0d4e5ab9795c3a573d9544
Autor:
Yogananda S. Markandeya, Zachery R. Gregorich, Li Feng, Vignesh Ramchandran, Thomas O' Hara, Ravi Vaidyanathan, Catherine Mansfield, Alexis M. Keefe, Carl J. Beglinger, Jabe M. Best, Matthew M. Kalscheur, Martin R. Lea, Timothy A. Hacker, Julia Gorelik, Natalia A. Trayanova, Lee L. Eckhardt, Jonathan C. Makielski, Ravi C. Balijepalli, Timothy J. Kamp
Publikováno v:
Journal of Molecular and Cellular Cardiology. 177:38-49
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eb152118a1a2203da32cab991cb2de6
https://doi.org/10.1016/j.yjmcc.2023.02.005
https://doi.org/10.1016/j.yjmcc.2023.02.005