Výsledky vyhledávání - "Julia, Benkert"

Akademický článek

Deep learning-based image analysis identifies a DAT-negative subpopulation of dopaminergic neurons in the lateral Substantia nigra

Autor: Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Liss

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-26 (2023)

Abstract Here we present a deep learning-based image analysis platform (DLAP), tailored to autonomously quantify cell numbers, and fluorescence signals within cellular compartments, derived from RNAscope or immunohistochemistry. We utilised DLAP to a

Externí odkaz: https://doaj.org/article/7e2313ece132485ba389be8ee8efcbe2

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Akademický článek

β2-subunit alternative splicing stabilizes Cav2.3 Ca2+ channel activity during continuous midbrain dopamine neuron-like activity

Autor: Anita Siller, Nadja T Hofer, Giulia Tomagra, Nicole Burkert, Simon Hess, Julia Benkert, Aisylu Gaifullina, Desiree Spaich, Johanna Duda, Christina Poetschke, Kristina Vilusic, Eva Maria Fritz, Toni Schneider, Peter Kloppenburg, Birgit Liss, Valentina Carabelli, Emilio Carbone, Nadine Jasmin Ortner, Jörg Striessnig

Publikováno v: eLife, Vol 11 (2022)

In dopaminergic (DA) Substantia nigra (SN) neurons Cav2.3 R-type Ca2+-currents contribute to somatodendritic Ca2+-oscillations. This activity may contribute to the selective degeneration of these neurons in Parkinson’s disease (PD) since Cav2.3-kno

Externí odkaz: https://doaj.org/article/9faa676ef6d24167b54187fd03cc356d

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Akademický článek

Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Voltage-gated Ca2+ channels are thought to contribute to neurodegeneration of dopaminergic neurons. Here the authors find that the R-type channel Cav2.3 in substantia nigra dopaminergic neurons may contribute to neurodegeneration in a model of Parkin

Externí odkaz: https://doaj.org/article/8271fb3221094175818e53f6966e1e51

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Akademický článek

NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra Dopaminergic Neurons

Autor: Carsten Simons, Julia Benkert, Nora Deuter, Christina Poetschke, Olaf Pongs, Toni Schneider, Johanna Duda, Birgit Liss

Publikováno v: Frontiers in Molecular Neuroscience, Vol 12 (2019)

Neuronal Ca2+ sensor proteins (NCS) transduce changes in Ca2+ homeostasis into altered signaling and neuronal function. NCS-1 activity has emerged as important for neuronal viability and pathophysiology. The progressive degeneration of dopaminergic (

Externí odkaz: https://doaj.org/article/1272925511dc46fea958148d00f598ff

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Reframing Business Sustainability Decision-Making with Value-Focussed Thinking

Autor: Julia Benkert

Publikováno v: Journal of Business Ethics. 174:441-456

Per definition business sustainability demands the integration of environmental, social, and economic outcomes. Yet, managerial decision-making involving sustainability objectives is fraught with tension and the way managerial decision-makers frame s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::734bc56490c694dde0da8cc62040b676
https://doi.org/10.1007/s10551-020-04611-4

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