Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Juli Feigon"'
Autor:
Yao He, He Song, Henry Chan, Baocheng Liu, Yaqiang Wang, Lukas Sušac, Z. Hong Zhou, Juli Feigon
Publikováno v:
Nature, vol 608, iss 7924
Nature
Nature
Telomeres are the physical ends of linear chromosomes. They are composed of short repeating sequences (such as TTGGGG in the G-strand for Tetrahymena thermophila) of double-stranded DNA with a single-strand 3'overhang of the G-strand and, in humans,
Autor:
Yao He, Juli Feigon
Publikováno v:
Current opinion in structural biology. 76
Telomerase is an RNA-protein complex comprising telomerase reverse transcriptase, a non-coding telomerase RNA, and proteins involved in biogenesis, assembly, localization, or recruitment. Telomerase synthesizes the telomeric DNA at the 3'-ends of lin
Publikováno v:
Nature, vol 604, iss 7906
Nature
Nature
Human telomerase is a RNA–protein complex that extends the 3′end of linear chromosomes by synthesizing multiple copies of the telomeric repeat TTAGGG(1). Its activity is a determinant of cancer progression, stem cell renewal and cellular aging(2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4945aa1bdc10087b155fbff582411542
https://escholarship.org/uc/item/0s5749sb
https://escholarship.org/uc/item/0s5749sb
Autor:
Yao He, He Song, Henry Chan, Yaqiang Wang, Baocheng Liu, Lukas Susac, Z. Hong Zhou, Juli Feigon
Telomeres are the physical ends of linear chromosomes, composed of short repeating sequences (e.g. TTGGGG in Tetrahymena for the G-strand) of double-stranded DNA with a single-strand 3’-overhang of the G-strand and a group of proteins called shelte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da63fa4d75cb4f93c5d1cb5ef42debb8
https://doi.org/10.1101/2021.12.28.474374
https://doi.org/10.1101/2021.12.28.474374
Publikováno v:
RNA biology, vol 18, iss 8
La-related proteins 7 (LARP7) are a class of RNA chaperones that bind the 3′ ends of RNA and are constitutively associated with their specific target RNAs. In metazoa, Larp7 binds to the long non-coding 7SK RNA as a core component of the 7SK RNP, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7029c76ad10023d442e8e40d0262dbaf
https://escholarship.org/uc/item/9rj7t5v4
https://escholarship.org/uc/item/9rj7t5v4
Autor:
Yuan Yang, Shiheng Liu, Sylvain Egloff, Catherine D. Eichhorn, Tanya Hadjian, James Zhen, Tamás Kiss, Z. Hong Zhou, Juli Feigon
Publikováno v:
Mol Cell
Molecular cell, vol 82, iss 9
Molecular cell, vol 82, iss 9
7SK non-coding RNA (7SK) negatively regulates RNA polymerase II (RNA Pol II) elongation by inhibiting positive transcription elongation factor b (P-TEFb), and its ribonucleoprotein complex (RNP) is hijacked by HIV-1 for viral transcription and replic
Publikováno v:
Nature chemical biology, vol 15, iss 2
Nature chemical biology
Nature chemical biology
Among RNA 5'-cap structures, γ-phosphate monomethylation is unique to a small subset of noncoding RNAs, 7SK and U6 in humans. 7SK is capped by methylphosphate capping enzyme (MePCE), which has a second nonenzymatic role as a core component of the 7S
Autor:
Woo Shik Shin, Douglas L. Black, Qin Cao, Lin Jiang, Kevin A. Murray, Henry Chan, David Eisenberg, Binsen Li, Bethany Dubois, Celine K. Vuong, Juli Feigon, Michael R. Sawaya
Publikováno v:
Nature chemistry
Inhibiting the interaction between ß-amyloid (Aß) and a neuronal cell surface receptor, LilrB2, has been suggested as a potential route for treating Alzheimer’s disease (AD). Supporting this approach, AD-like symptoms are reduced in mouse models
Publikováno v:
Proc Natl Acad Sci U S A
Telomerase is a ribonucleoprotein complex that counteracts the shortening of chromosome ends due to incomplete replication. Telomerase contains a catalytic core of telomerase reverse transcriptase (TERT) and telomerase RNA (TER). However, what define
Autor:
Baocheng Liu, Z. Hong Zhou, Ryan Cheng, Lukas Sušac, Juli Feigon, Yao He, Christina Helmling, Yaqiang Wang
Publikováno v:
Nature
Nature, vol 593, iss 7859
Nature, vol 593, iss 7859
Telomerase is unique among the reverse transcriptases in containing a noncoding RNA (known as telomerase RNA (TER)) that includes a short template that is used for the processive synthesis of G-rich telomeric DNA repeats at the 3′ ends of most euka